Entry
Name
[CysO sulfur-carrier protein]-S-L-cysteine hydrolase;
mec (gene name)
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds
BRITE hierarchy
Sysname
[CysO sulfur-carrier protein]-S-L-cysteine sulfohydrolase
Reaction(IUBMB)
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O = [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine [RN:
R11523 R11524 ]
Reaction(KEGG)
Substrate
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine;
H2O [CPD:
C00001 ]
Product
[CysO sulfur-carrier protein]-Gly-NH-CH2-COOH;
L-cysteine [CPD:
C00097 ]
Comment
Requires Zn2+. The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in an L-cysteine biosynthesis pathway. It acts on the product of EC
2.5.1.113 , [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
History
EC 3.13.1.6 created 2017
Orthology
K21140 [CysO sulfur-carrier protein]-S-L-cysteine hydrolase
Genes
POJ : PtoMrB4_26880 PtoMrB4_37670
DAK : DaAHT2_0588 DaAHT2_0869
MRM : A7982_06711 A7982_12831
BBE : BBR47_17340 BBR47_48390
BFM : BP422_03850 BP422_20015
BCHS : JNE38_09430 JNE38_26020
MBAI : MB901379_03528(mec)
MHEK : JMUB5695_01730(mec)
MPHL : MPHLCCUG_03884(mec)
MAUU : NCTC10437_04037(mec)
MFLV : NCTC10271_01411(mec)
MSAL : DSM43276_01341(mec)
NFR : ERS450000_03022(mec)
NAD : NCTC11293_01985(mec)
SLE : sle_43590(sle_43590)
SXT : KPP03845_103037(mec)
NAQU : ENKNEFLB_03481(mec)
LED : BBK82_03315 BBK82_06125
BALA : DSM104299_04362(mec)
KBS : EPA93_42450 EPA93_44665
KBB : ccbrp13_18860 ccbrp13_65360
» show all
Taxonomy
Reference
Authors
Burns KE, Baumgart S, Dorrestein PC, Zhai H, McLafferty FW, Begley TP
Title
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.6
ExPASy - ENZYME nomenclature database: 3.13.1.6