KEGG ENZYME: 3.2.1.123

ENZYME: 3.2.1.123

Entry

EC 3.2.1.123                Enzyme

Name

endoglycosylceramidase;
endoglycoceramidase;
EGCase;
glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase;
oligoglycosylglucosylceramide glycohydrolase;
oligoglycosylglucosyl(1<->1)ceramide glycohydrolase

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

oligoglycosylglucosyl-(1<->1)-ceramide glycohydrolase

Reaction(IUBMB)

oligoglycosylglucosyl-(1<->1)-ceramide + H2O = ceramide + oligoglycosylglucose [RN:R04118 R06157]

Reaction(KEGG)

R04118 R06157(G);
(other) R06283(G)

Substrate

oligoglycosylglucosyl-(1<->1)-ceramide;
H2O [CPD:C00001]

Product

ceramide [CPD:C00195];
oligoglycosylglucose [CPD:C03018]

Comment

An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.

History

EC 3.2.1.123 created 1989

Orthology

K05991

endoglycosylceramidase

Genes

BFO:	118407464 118407480

BBEL:

109477355

FCD:

110852051

EAF:	111706602 111709234 111709909

LSM:

121116947

TCF:

131878157

HRO:	HELRODRAFT_86747

LAK:

106179962

SMM:	Smp_120050 Smp_155570

SHX:	MS3_00008883

OVI:	T265_04204 T265_13449

NVE:	5501331 5516730

EPA:

110232166

ATEN:

116296699 116296702

ADF:

107334423

AMIL:

114950972

PDAM:

113667552

SPIS:

111330991

DGT:

114533612

XEN:

124440633

HMG:

100192295

HSY:

130640949

AQU:	100634050 100639716

PPP:

112281139

CSL:	COCSUDRAFT_68001

FVR:	FVEG_12913

FOX:	FOXG_16909

FMU:	J7337_013678

MAW:

MAC_02340

MAJ:

MAA_10290

PCHM:

VFPPC_06874

CMT:

CCM_04551

AMUS:

LMH87_011561

PLJ:	VFPFJ_06511

PTKZ:

JDV02_000048

AFM:	AFUA_5G00550

NFI:	NFIA_041960

AOR:	AO090012000006

AFV:	AFLA_001713

TMS:	TREMEDRAFT_61952

MBR:	MONBRDRAFT_1029 MONBRDRAFT_9488

SRE:	PTSG_04956 PTSG_12288

DDI:	DDB_G0270074

DPP:	DICPUDRAFT_148335

DFA:	DFA_08187 DFA_12093

ACAN:

ACA1_251790

TET:	TTHERM_00283480 TTHERM_00283490 TTHERM_00429930 TTHERM_00476450

PTM:	GSPATT00026357001 GSPATT00029272001 GSPATT00031065001 GSPATT00032672001

SMIN:

v1.2.006292.t1(symbB.v1.2.006292.t1)

AAF:	AURANDRAFT_23504(EGN1)

EHX:	EMIHUDRAFT_66695

GTT:	GUITHDRAFT_157591 GUITHDRAFT_46636

NGR:	NAEGRDRAFT_32211

LCP:	LC55x_3709

KAK:	Kalk_10570

ZAL:	AZF00_16475

SOK:	D0B54_08670

GPB:	HDN1F_20130

BCH:	Bcen2424_5653

PMEG:

FNZ07_03730

NOV:	TQ38_028330

SPHB:

EP837_03631

PAUU:

E8A73_021165

MRM:	A7982_09064

SAMY:

DB32_006343

BTRO:

FJR70_30715

PLW:	D5F53_31055

PDY:	QJQ58_17365

LHB:	D1010_01990

VGU:	HYG85_14075

MKN:	MKAN_03410

MYE:	AB431_05450 AB431_09420

MNM:	MNVM_09570 MNVM_09580 MNVM_20330 MNVM_24980

MCOO:

MCOO_48690

MPAA:

MKK62_16900

MCB:	Mycch_1466

MAIC:

MAIC_16130

MPSC:

MPSYJ_29730

MHEV:

MHEL_40280

MSAR:

MSAR_01450

MAUB:

MAUB_39620

MPHU:

MPHO_30170

MMUC:

C1S78_003840

MPAE:

K0O64_08875

MRF:	MJO55_17130

MCRO:

MI149_10085

MJD:	JDM601_0882 JDM601_0884 JDM601_3582 JDM601_4151

MTER:

4434518_00844 4434518_04091

MMIN:

MMIN_11060 MMIN_15890 MMIN_22200 MMIN_22210 MMIN_22230 MMIN_25070 MMIN_25080

MHIB:

MHIB_03760 MHIB_03770 MHIB_21720 MHIB_21730 MHIB_29810 MHIB_40340

MHER:

K3U94_02935 K3U94_02940 K3U94_02955 K3U94_04795 K3U94_04850 K3U94_11020 K3U94_15655 K3U94_22645

MVM:	MJO54_02935 MJO54_02940 MJO54_22715

CKP:	ckrop_1577

CFN:	CFAL_10950

COA:

DR71_1819

CAMC:

I6I65_00495

CHEI:

CHEID_09700 CHEID_09705

CPYR:

CYJ47_05895

NBR:	O3I_025405

NSL:	BOX37_23115

NSR:	NS506_00675 NS506_07799

NTP:	CRH09_35285

NOZ:	DMB37_02055

NOD:	FOH10_27820

NAH:	F5544_23650 F5544_31250 F5544_31470

NAD:	NCTC11293_05611

NIE:	KV110_15315 KV110_22185

NTC:	KHQ06_02860 KHQ06_36855 KHQ06_36860

NHU:	H0264_04770 H0264_11865 H0264_21890

NYA:	LTV02_28030

NYU:	D7D52_05265

RER:	RER_26700 RER_56930

REY:	O5Y_12270 O5Y_27195

REB:	XU06_12465 XU06_27470

RQI:	C1M55_13505 C1M55_29060

RHOD:

AOT96_08730 AOT96_23705

REQ:	REQ_10740 REQ_13700 REQ_38260

PDEF:

P9209_26855

TOY:	FO059_00195 FO059_17720

SGR:

SGR_2234

SGB:

WQO_24285

SFI:

SFUL_5095

SANL:

KZO11_25790

SCYE:

R2B67_10140

SHY:

SHJG_7711

SHO:	SHJGH_7473

SVE:

SVEN_4954

SCI:	B446_00590 B446_34700

SGU:	SGLAU_02095

SVT:	SVTN_25570

STRE:

GZL_00745

SLD:

T261_7793

SLC:	SL103_19175

SPRI:

SPRI_2608

SCZ:	ABE83_11055

SRW:	TUE45_07374

SRN:	A4G23_03887(celC)

SALW:

CP975_00460

SNR:	SNOUR_03555

SALU:

DC74_8045

SALL:

SAZ_41555

SPLU:

LK06_028855

SVU:	B1H20_24815

SGV:	B1H19_05605

SLAU:

SLA_5106

SALF:

SMD44_08570

SALJ:

SMD11_2261

SLX:	SLAV_36905

STRO:

STRMOE7_07720

SFK:

KY5_5124

SLK:	SLUN_26690

SKA:	CP970_15640

SVN:	CP980_00800

SRK:	FGW37_22145

SFIC:

EIZ62_10445

SVR:	CP971_10155

SCAV:

CVT27_23580

SCIN:

CP977_23360

SGX:	H4W23_27075

SSPB:

CP982_40440

SPLA:

CP981_30240

SATA:

C5746_27945

SHUN:

DWB77_02953

SCYG:

S1361_33585(celC)

SDW:	K7C20_35075

SCAL:

I6J39_24570

SAUH:

SU9_000080 SU9_033765

SFB:	CP974_21045

SMOB:

J7W19_21870

SPEU:

CGZ69_23835

SXN:	IAG42_14050

SHK:	J2N69_35545

SANU:

K7396_00620

SDD:	D9753_04620

SACT:

DMT42_35700

SGOB:

test1122_18915

SINE:

KI385_42030

SAOV:

G3H79_00780

STAA:

LDH80_13795

SNIG:

HEK616_82290

SLON:

LGI35_43485

STUD:

STRTU_000509

SENG:

OJ254_28875

SYUN:

MOV08_03050

SOV:	QZH56_10185

SHAU:

K9S39_38155

SLAI:

P8A22_34500

SFP:	QUY26_01185

SCHG:

NRO40_20230

KAB:	B7C62_25385

KAU:	B6264_05235

KIT:	CFP65_5323

KIS:	HUT16_25365

STRH:

GXP74_14365

LSE:	F1C12_07170

MRG:	SM116_06095

MVD:	AWU67_04485

AGY:	ATC03_16595

AMAU:

DSM26151_27750

ARM:

ART_1927

GPR:	JQN66_06030

BCV:

Bcav_2260

BRV:	CFK39_10330

BRZ:	CFK38_00380

PSEI:

GCE65_05745

PAC:	PPA0644 PPA2106

PAK:	HMPREF0675_3711 HMPREF0675_5160

PAV:	TIA2EST22_03250 TIA2EST22_10250

PAX:	TIA2EST36_03225 TIA2EST36_10230

PAZ:	TIA2EST2_03170 TIA2EST2_10190

PAW:	PAZ_c06820 PAZ_c21810

PAD:	TIIST44_03240 TIIST44_11280

PCN:	TIB1ST10_03325 TIB1ST10_10695

PACC:

PAC1_03350 PAC1_10690

PACH:

PAGK_1485 PAGK_2000

PACN:

TIA1EST1_03240 TIA1EST1_10305

CACN:

RN83_03740 RN83_10745

PRA:	PALO_00580

PRL:	BCB70_07915

MIK:	FOE78_19485

TDF:	H9L22_09625

NCA:

Noca_3558

NBE:	Back2_27870

NARO:

CFH99_08485

AEB:	C6I20_12985

NAL:

B005_1763

NGV:	CDO52_02365

NFE:	HUT17_01340

NEX:	NE857_33290

NCG:	KGD84_01185

ACTW:

F7P10_25690

ACIR:

OG979_24140

SPIQ:

OHA34_18410

ACTQ:

OG417_38935

SRO:

Sros_1713

SEN:

SACE_3752

KBU:	Q4V64_33830

ACTI:

UA75_06875

ACAD:

UA74_06880

AHG:	AHOG_06610

CATI:

CS0771_61510

SNA:

Snas_0664

APHO:

JTE88_00990

AEY:	CDG81_11150

CWO:

Cwoe_0370

PARN:

NBH00_04345

AQZ:	KSP35_14740

IAM:	HC251_12135

SACI:

Sinac_0727

VBL:	L21SP4_00071 L21SP4_00900

LBI:	LEPBI_I2486

LBF:

LBF_2411

LAJ:	A0128_03105

LKM:	EFP84_13910

PCOP:

I6J50_01230

EST:	DN752_23380

MARE:

EJ994_10175

SEON:

BWZ22_10440

FEK:	C1H87_00625

HWS:	RNZ46_01080

» show all

Reference

1 [PMID:3771534]

Authors

Ito M, Yamagata T.

Title

A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids.

Journal

J Biol Chem 261:14278-82 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.123

IUBMB Enzyme Nomenclature:

3.2.1.123

ExPASy - ENZYME nomenclature database:

3.2.1.123

BRENDA, the Enzyme Database:

3.2.1.123

CAS:	105503-61-5

DBGET integrated database retrieval system