KEGG   ENZYME: 3.2.1.197
Entry
EC 3.2.1.197                Enzyme                                 
Name
beta-1,2-mannosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
beta-1,2-D-mannoside mannohydrolase
Reaction(IUBMB)
beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-D-mannopyranose + H2O = beta-D-mannopyranosyl-(1->2)-D-mannopyranose + alpha-D-mannopyranose [RN:R11544]
Reaction(KEGG)
R11544
Substrate
beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-D-mannopyranose [CPD:C21454];
H2O [CPD:C00001]
Product
beta-D-mannopyranosyl-(1->2)-D-mannopyranose [CPD:C21336];
alpha-D-mannopyranose [CPD:C00936]
Comment
The enzyme, characterized from multiple bacterial species, catalyses the hydrolysis of terminal, non-reducing D-mannose residues from beta-1,2-mannotriose and beta-1,2-mannobiose. The mechanism involves anomeric inversion, resulting in the release of alpha-D-mannopyranose. Activity with beta-1,2-mannotriose or higher oligosaccharides is higher than that with beta-1,2-mannobiose.
History
EC 3.2.1.197 created 2016
Orthology
K21065  beta-1,2-mannosidase
Genes
CAK: Caul_5274
SPAI: FPZ24_15095
SARI: H5J25_15640
PMS: KNP414_03490
PMQ: PM3016_1378
PMW: B2K_07040
PLYC: GXP70_21885
TMR: Tmar_1533
THEF: E1B22_11255
THEP: DYI95_007675
SDX: C4B68_17345
LEIF: HF024_07910
LSE: F1C12_10730
MIM: AKG07_12235
MIX: AB663_000749
MICR: BMW26_16950
MRN: K8F61_02010
FRN: F1C15_06880
BCV: Bcav_2271
BFA: Bfae_04900
BRX: BH708_03160
BRV: CFK39_10515
BRZ: CFK38_00195
BRR: C1N80_00765
BKI: M4486_15525
BRHA: NLU66_00600
BHH: Bra3105_12440
TEH: GKE56_04465
HALT: IM660_06775
RHAL: LQF10_12880
MIK: FOE78_02265
MICG: GJV80_09435
NPS: KRR39_23745
SACG: FDZ84_33085
ATL: Athai_51240
BSCA: BBSC_0973
BEU: BE0216_09775
FGI: OP10G_4571
CCOT: CCAX7_11070
PHM: PSMK_15170
MCAD: Pan265_13500
ABA: Acid345_0916
ACA: ACP_0702
ACM: AciX9_3592
TSA: AciPR4_4005
TRS: Terro_0837
TALB: FTW19_09990
ABAS: ACPOL_0357
EDA: GWR55_17895
EDG: H7846_05525
ADIN: H7849_05105
SUS: Acid_4608
PFER: IRI77_12455
BTH: BT_3780 BT_4094
BTHO: Btheta7330_00213 Btheta7330_04130 Btheta7330_04506
BXY: BXY_31780 BXY_48370
BOA: Bovatus_02994 Bovatus_03907 Bovatus_04344
BCEL: BcellWH2_02647
BCAE: A4V03_00905 A4V03_17495
BIS: DXK01_004125
BFE: K6V30_03355 K6V30_07380 K6V30_08880
BNO: K8P02_03930
BFC: BacF7301_04540 BacF7301_07610
PSAC: PSM36_1078
PROJ: KDN43_09410 KDN43_13445
PDI: BDI_3141
PARC: CI960_21960
PMER: INE87_02059
PJO: LK449_00190
ASEN: NQ519_05420
DRC: G0Q07_17235
MCOS: GM418_08360
ANF: AQPE_2253
CPI: Cpin_6158
CBAE: COR50_03215
CHIT: FW415_15625
CHIH: GWR21_10565
CFIL: MYF79_26535
CHF: KTO58_22020
NKO: Niako_1662
NSO: NIASO_16785
NIA: A8C56_19890
NYN: U0035_21275
FLA: SY85_19465
FGG: FSB75_06065
ARB: A9P82_10265
ARK: D6B99_07660
AGI: FSB73_10385
ATEE: K9M52_10785
ARAC: E0W69_000090
PGIN: FRZ67_04795
PGO: FSB84_10220
LACS: H4075_01605
FLC: KJS93_15540
FLV: KJS94_01635
THEO: IMW88_03750
HHY: Halhy_2351
PGS: CPT03_16470
PEK: FFJ24_020360
PROE: H9L23_21415
PEX: IZT61_02260
PMUO: LOK61_09105
SHG: Sph21_4796
SPHN: BV902_14695
SMIZ: 4412673_02100
SPDR: G6053_14035
SDJ: NCTC13534_03034
STHA: NCTC11429_01489
SMUI: I6J00_03310 I6J00_17920
SSIY: JVX97_18795
SBAM: SCB77_14465
MUP: A0256_16760
MUC: MuYL_0039
MGOT: MgSA37_03900
MUH: HYN43_010370
MGIN: FRZ54_22630
MGK: FSB76_17655
MRUB: DEO27_010495
MGOS: DIU38_010975
MGIK: GO620_002360
MDJ: LLH06_11940
MJJ: PQO05_18305
MSAB: SNE25_05025 SNE25_15985
OLI: FKG96_21805
CAMU: CA2015_3661
ALM: AO498_07455
ALGO: GYM62_09995
MDA: IPZ59_04480
SLI: Slin_3919
SRD: SD10_20120
SPIR: CWM47_22390
SPIK: EXU85_25500
SOQ: LQ777_24730
SFOL: H3H32_21900
RHOZ: GXP67_27410
PSEZ: HME7025_02135
AANH: G9X63_07555
ALEN: G9X62_07550
DFE: Dfer_3176
DSN: HWI92_14995
DYC: NFI80_21590
DFQ: NFI81_22730
DCN: MUK70_27025
DPF: ON006_21520
RSI: Runsl_2228
RUN: DR864_20065
RUP: DTQ70_19295
EOL: Emtol_2662
EMZ: MB380_06350
FIB: A6C57_04200
MAQA: LAG90_17265
HYE: AM218_15635
HYZ: AXW84_01505
HNV: DDQ68_17335
HYJ: FHG12_02105
HAEI: MUN82_16490
ADD: HUW48_24935
ASWU: HUW51_08075
IRO: RT717_27320
CHRW: KA713_16235
CHK: D4L85_07830
FLW: LVD16_17005
TPEL: P0M28_10895
GRL: LPB144_11785
GFL: GRFL_1111
GRS: C7S20_03760
FAO: SHINM13_10960
FAN: GENT5_10510
FKE: MG292_05785
RBI: RB2501_13184
ZPR: ZPR_0445
FBC: FB2170_14743
MART: BTR34_02150
MARB: CJ263_16555
MLIO: NYZ99_12085
SYI: SB49_02230
AUE: C5O00_11460
MUR: EQY75_04415
ASAG: FGM00_05115
MRS: Murru_1532
MLT: VC82_1561
ALUT: O5O44_06230
KPF: IX53_05415
MPG: Theba_1903
MINF: MESINF_1199
THV: ADU37_CDS02900
 » show all
Reference
1  [PMID:26286752]
  Authors
Cuskin F, Basle A, Ladeveze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Veronese G, Lowe EC
  Title
The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target beta-1,2-Mannosidic Linkages in Candida Mannan.
  Journal
J Biol Chem 290:25023-33 (2015)
DOI:10.1074/jbc.M115.681460
  Sequence
[bth:BT_3780]
Reference
2  [PMID:26476324]
  Authors
Nihira T, Chiku K, Suzuki E, Nishimoto M, Fushinobu S, Kitaoka M, Ohtsubo K, Nakai H
  Title
An inverting beta-1,2-mannosidase belonging to glycoside hydrolase family 130 from Dyadobacter fermentans.
  Journal
FEBS Lett 589:3604-10 (2015)
DOI:10.1016/j.febslet.2015.10.008
  Sequence
[dfe:Dfer_3176]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.197
IUBMB Enzyme Nomenclature: 3.2.1.197
ExPASy - ENZYME nomenclature database: 3.2.1.197
BRENDA, the Enzyme Database: 3.2.1.197

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2858)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (199)   
   KEGG MGENES (2460)   
   RefGene (198)   
All databases (2864)   

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