KEGG ENZYME: 3.2.1.198

ENZYME: 3.2.1.198

Entry

EC 3.2.1.198                Enzyme

Name

alpha-mannan endo-1,2-alpha-mannanase

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

alpha-mannan 1,2-[alpha-D-mannosyl-(1->3)-alpha-D-mannose] hydrolase

Reaction(IUBMB)

Hydrolysis of the terminal alpha-D-mannosyl-(1->3)-alpha-D-mannose disaccharide from alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl side chains in fungal cell wall alpha-mannans.

Comment

The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase.

History

EC 3.2.1.198 created 2016

Orthology

K21132

alpha-mannan endo-1,2-alpha-mannanase / glycoprotein endo-alpha-1,2-mannosidase

Genes

NPI:	G7071_01355

BTH:

BT_3862

BTHO:

Btheta7330_00449

BXY:

BXY_34140

BFE:	K6V30_07760

BFIN:

BFINE_24560

Reference

1 [PMID:25487964]

Authors

Hakki Z, Thompson AJ, Bellmaine S, Speciale G, Davies GJ, Williams SJ

Title

Structural and kinetic dissection of the endo-alpha-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.

Journal

Chemistry 21:1966-77 (2015)
DOI:10.1002/chem.201405539

Sequence

[bth:BT_3862] [bxy:BXY_34140]

Reference

2 [PMID:25567280]

Authors

Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munoz-Munoz JL, Day A, Pena MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ

Title

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.

Journal

Nature 517:165-9 (2015)
DOI:10.1038/nature13995

Sequence

[bth:BT_3862]

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.198

IUBMB Enzyme Nomenclature:

3.2.1.198

ExPASy - ENZYME nomenclature database:

3.2.1.198

BRENDA, the Enzyme Database:

3.2.1.198

All links

Gene (7)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (6)   
All databases (7)   

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