KEGG ENZYME: 3.2.1.208

ENZYME: 3.2.1.208

Entry

EC 3.2.1.208                Enzyme

Name

glucosylglycerate hydrolase;
GG hydrolase;
GgH

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

2-O-(alpha-D-glucopyranosyl)-D-glycerate D-glucohydrolase

Reaction(IUBMB)

2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate [RN:R12250]

Reaction(KEGG)

R12250

Substrate

2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD:C19792];
H2O [CPD:C00001]

Product

D-glucopyranose [CPD:C00031];
D-glycerate [CPD:C00258]

Comment

The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(alpha-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation.

History

EC 3.2.1.208 created 2018

Orthology

K23086

glucosylglycerate hydrolase

Genes

MSA:	Mycsm_06486

MMC:

Mmcs_5386

MKM:

Mkms_5475

MJL:

Mjls_5762

MYV:	G155_30065

MYE:	AB431_29155

MDX:	BTO20_00165

MGAU:

MGALJ_43180

MADI:

A7U43_02890

MSM:	MSMEG_6914

MSG:	MSMEI_6727

MSB:	LJ00_34150

MSN:	LI99_34155

MSH:	LI98_34160

MVA:

Mvan_6050

MGI:

Mflv_0855

MSP:	Mspyr1_53190

MCB:	Mycch_5302

MNE:	D174_02315

MYN:	MyAD_02255

MFT:	XA26_60790

MPHL:

MPHLCCUG_05188

MVQ:

MYVA_5979

MLL:	B1R94_29065

MRH:	MycrhN_1791

MTHN:

4412656_04702

MHAS:

MHAS_04250

MDU:	MDUV_42970

MCHT:

MCHIJ_14880

MDR:	MDOR_38100

MAUU:

NCTC10437_05735

MMAG:

MMAD_00440

MMOR:

MMOR_04270

MFX:	MFAL_27090

MAIC:

MAIC_56730

MIJ:	MINS_05700

MALV:

MALV_35380

MTY:	MTOK_16540

MPSC:

MPSYJ_08820

MARZ:

MARA_38720

MGAD:

MGAD_42690

MHEV:

MHEL_22340

MSAR:

MSAR_15430

MANY:

MANY_38840

MAUB:

MAUB_33430

MPOF:

MPOR_05370

MPHU:

MPHO_36570

MMUC:

C1S78_029560

MMAT:

MMAGJ_24700

MBOK:

MBOE_11980

MFG:	K6L26_01395

MSEI:

MSEDJ_12680

MFLV:

NCTC10271_05165

MCEE:

MCEL_32000

MBRM:

L2Z93_003823

MMON:

EWR22_28930

MGO:	AFA91_06610

MHOL:

K3U96_00140

MSEN:

K3U95_28810

MPAE:

K0O64_29325

MRF:	MJO55_27630

MDF:	K0O62_00140

MCRO:

MI149_29075

MGRO:

FZ046_06605

MAB:

MAB_4920c

MMV:	MYCMA_02765

MABB:

MASS_4921

MABL:

MMASJCM_4914

MCHE:

BB28_24665

MIZ:	BAB75_27375

MSTE:

MSTE_05003

MSAO:

MYCSP_22495

MSAL:

DSM43276_04651

ASD:

AS9A_4418

CCYC:

SCMU_37110

NFA:

NFA_55270

NFR:	ERS450000_04333

NCY:	NOCYR_5405

NBR:	O3I_041095

NNO:	NONO_c75000

NSL:	BOX37_31715

NSR:	NS506_00440(treA)

NTP:	CRH09_38745

NOZ:	DMB37_20065

NOD:	FOH10_32525

NAH:	F5544_44485

NAD:	NCTC11293_00576

NWL:	NWFMUON74_69960

NIE:	KV110_40310

NTC:	KHQ06_05105

NHU:	H0264_00500

NYA:	LTV02_32465

NGP:	LTT66_11030

NSPU:

IFM12276_61780

NYU:	D7D52_21785

RHA:	RHA1_ro03533

RER:

RER_59670

REY:

O5Y_28595

REB:	XU06_28925

RQI:	C1M55_30410

ROP:

ROP_33260

ROA:	Pd630_LPD07919

RPY:	Y013_16235

RBY:	CEJ39_02690

RHB:

NY08_3630

RAV:	AAT18_26360

RFA:	A3L23_01782

RHS:	A3Q41_01582

RRZ:	CS378_15800

RHQ:	IM25_06135

RHOD:

AOT96_10060

RRT:	4535765_04876

RCR:	NCTC10994_02668

RTM:	G4H71_10710

RKO:	JWS14_18545

RGO:	KYT97_19195

ROZ:	CBI38_29825

RPSK:

JWS13_25935

RGOR:

NMQ04_20740

RHOP:

D8W71_03845

REQ:

REQ_46910

PDEF:

P9209_03855

WHR:	OG579_12665

GBR:

Gbro_4815

GPO:	GPOL_c49820

GOR:

KTR9_4692

GTA:	BCM27_24885

GRU:	GCWB2_23635

GOM:	D7316_03577

GAV:	C5O27_04885

GOD:	GKZ92_22535

GAM:	GII34_00475

GPD:	GII33_00460

GJI:	H1R19_22765

GOI:	LK459_09550

GHN:	MVF96_23530

GAMI:

IHQ52_04450

GMG:	NWF22_10365

SPIN:

KV203_19120

SRT:

Srot_1138

LSE:	F1C12_17410

ARTH:

C3B78_17935

APN:	Asphe3_36090

POK:	SMD14_18425

BCV:

Bcav_1673

RAIN:

Rai3103_13920

PRV:	G7070_16930

TFU:

Tfu_1750

THAO:

NI17_010800

TALX:

FOF52_08295

TCU:

Tcur_2002

ACTQ:

OG417_52290

MMAR:

MODMU_1256

SVI:	Svir_34840

SACC:

EYD13_19350

AMQ:	AMETH_5004

AACD:

LWP59_30110

ATHM:

L1857_27800

CROS:

N8J89_19255

ATL:	Athai_30050

ASER:

Asera_44500

SNA:

Snas_0169

JTL:	M6D93_06605

RRD:	RradSPS_1613

RUB:	GBA63_11750

RMAR:

GBA65_09330

AQZ:	KSP35_09345

» show all

Reference

1 [PMID:25341489]

Authors

Alarico S, Costa M, Sousa MS, Maranha A, Lourenco EC, Faria TQ, Ventura MR, Empadinhas N

Title

Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.

Journal

Sci Rep 4:6766 (2014)
DOI:10.1038/srep06766

Sequence

[mhas:MHAS_04250]

Reference

2 [PMID:28876234]

Authors

Cereija TB, Alarico S, Empadinhas N, Pereira PJB

Title

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase.

Journal

Acta Crystallogr F Struct Biol Commun 73:536-540 (2017)
DOI:10.1107/S2053230X17012419

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.208

IUBMB Enzyme Nomenclature:

3.2.1.208

ExPASy - ENZYME nomenclature database:

3.2.1.208

BRENDA, the Enzyme Database:

3.2.1.208

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (174)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (167)   
   KEGG MGENES (6)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (3)   
All databases (189)   

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