KEGG   ENZYME: 3.2.1.217
Entry
EC 3.2.1.217                Enzyme                                 
Name
exo-acting protein-alpha-N-acetylgalactosaminidase;
Nag31
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
[protein]-N-acetyl-alpha-D-galactosalaminyl-(L-serine/L-threonine) N-acetylgalactosaminohydrolase
Reaction(IUBMB)
a [protein]-N-acetyl-alpha-D-galactosalaminyl-(L-serine/L-threonine) + H2O = a [protein]-(L-serine/L-threonine) + N-acetyl-D-galactosamine
Substrate
[protein]-N-acetyl-alpha-D-galactosalaminyl-(L-serine/L-threonine);
H2O [CPD:C00001]
Product
[protein]-(L-serine/L-threonine);
N-acetyl-D-galactosamine [CPD:C01132]
Comment
The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it. Unlike EC 3.2.1.49, alpha-N-acetylgalactosaminidase, it is not able to act on blood group A antigen.
History
EC 3.2.1.217 created 2022
Orthology
K25767  exo-acting protein-alpha-N-acetylgalactosaminidase
Genes
BMOR101736596
BMAN114243357
MSEX115450246
DPLKGM_202361
BANY112046906
PMAC106711011
PPOT106110492
PXU106118660
PRAP110995089
ZCE119836747
HAW110383195
HZE124642371
OFU114351652
PXY105384829
BONA361_11275
CPSSM5V91_10270
NMKCHR53_24385
SSTESAMEA4384403_1530(yicI)
LKLDKL58_02035
LAPIDKL56_01420
LPAIGYM71_02220
LXOKIM322_03140
LCALSEI_2769
LPQAF91_13535
LRHLGG_02762
LRGLRHM_2656
LRLLC705_02750
LRALRHK_2864
LROLOCK900_2751
LRCLOCK908_2838
LCHIKG086_12835
LHNLHUE1_000906
LAHLA20533_03300
XAKKIMC2_13330
XAPXA3_13080
EFAEF1824
EFIOG1RF_11531
CPECPE1046
CPFCPF_1301
CGASJ1C67_16390
SINTK5I26_04475
ERDG7062_02650
AARGAargi30884_28400
ABSIA9CBEGH2_00940
LCGL3BBH23_27060
TSFNQ543_00500
CSTCLK434_08415
COLLKPC83_00140
AMUAmuc_1008
ABIWAbiwalacus_11670
AMAKJ5W79_04855
SOAG3M56_011200
BTHBT_3169
BTHOBtheta7330_05128(yicI_6)
BFRBF1144
BFSBF9343_1013
BFGBF638R_1132
BFBVU15_04960
BHLBache_0124
BCACCGC64_02900 CGC64_03580
BFEK6V30_04465
BNOK8P02_16065
BFCBacF7301_03620 BacF7301_04830
PCOPI6J50_14725
PMERINE87_00261
PGOLK6V26_08940
PJOLK449_05825
PFAINXY11_08455
PIINF347_13175
PMZHMPREF0659_A7381
PJECRM71_14015
PSCJJ4856_04675
PEOAS203_00170
ALQC7Y71_011485
RBCBN938_0815
MBASALGA_0441
NIAA8C56_09265
NYNU0035_15170
ARKD6B99_06115
AGIFSB73_13195
ATEEK9M52_12965
ARACE0W69_008235
PSEGD3H65_16010
PEPAQ505_07100
PSTYBFS30_17250
PROEH9L23_06945
PGJQG516_07795
SHTKO02_06075
SPHNBV902_23070
SMIZ4412673_02693(yicI_2)
SPHZE3D81_05755
SPHEGFH32_07990
SPDRG6053_05920
STHANCTC11429_00510(yicI_2)
SMUII6J00_11580
SSIYJVX97_08195
SFAEMUK51_12900
SBAMSCB77_15165
MMABHQ865_15380
SBXCA265_05780
EMAIKZP23_11075
GRSC7S20_18750
CCMCcan_20520
ORHOrnrh_0292
ORIQ785_01585
EAOBD94_2015
EMNM876_07100
EENBBD30_16845
ELBVO54_00720(yicI)
EMGBBD33_12735
EGOBBD34_18255
EGMAYC65_08245
ELZFCS00_00990
ELTFGE20_01140
ELIZJCR23_18085
CPIPCJF12_06415
 » show all
Reference
1  [PMID:31530641]
  Authors
Rahfeld P, Wardman JF, Mehr K, Huff D, Morgan-Lang C, Chen HM, Hallam SJ, Withers SG.
  Title
Prospecting for microbial alpha-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase.
  Journal
J Biol Chem 294:16400-16415 (2019)
DOI:10.1074/jbc.RA119.010628
  Sequence
Reference
2  [PMID:32367553]
  Authors
Miyazaki T, Park EY.
  Title
Crystal structure of the Enterococcus faecalis alpha-N-acetylgalactosaminidase, a member of the glycoside hydrolase family 31.
  Journal
FEBS Lett 594:2282-2293 (2020)
DOI:10.1002/1873-3468.13804
  Sequence
[efa:EF1824]
Reference
3  [PMID:33742736]
  Authors
Ikegaya M, Miyazaki T, Park EY.
  Title
Biochemical characterization of Bombyx mori alpha-N-acetylgalactosaminidase belonging to the glycoside hydrolase family 31.
  Journal
Insect Mol Biol 30:367-378 (2021)
DOI:10.1111/imb.12701
Reference
4  [PMID:34826537]
  Authors
Miyazaki T, Ikegaya M, Alonso-Gil S.
  Title
Structural and mechanistic insights into the substrate specificity and hydrolysis of GH31 alpha-N-acetylgalactosaminidase.
  Journal
Biochimie 195:90-99 (2022)
DOI:10.1016/j.biochi.2021.11.007
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.217
IUBMB Enzyme Nomenclature: 3.2.1.217
ExPASy - ENZYME nomenclature database: 3.2.1.217
BRENDA, the Enzyme Database: 3.2.1.217

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