KEGG   ENZYME: 3.2.2.29
Entry
EC 3.2.2.29                 Enzyme                                 
Name
thymine-DNA glycosylase;
mismatch-specific thymine-DNA glycosylase;
mismatch-specific thymine-DNA N-glycosylase;
hTDG;
hsTDG;
TDG;
thymine DNA glycosylase;
G/T glycosylase;
uracil/thymine DNA glycosylase;
T:G mismatch-specific thymidine-DNA glycosylase;
G:T mismatch-specific thymine DNA-glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction(IUBMB)
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
EC 3.2.2.29 created 2009
Orthology
K20813  thymine-DNA glycosylase
Genes
HSA6996(TDG)
PTR452188(TDG)
PPS100980045(TDG) 100989432
GGO101130939(TDG)
PON100452129(TDG)
NLE100598008(TDG)
HMH116478023(TDG)
MCC700061(TDG)
MCF101866862(TDG)
MTHB126930905
MNI105497729(TDG)
CSAB103238979(TDG)
CATY105573292(TDG)
PANU101017410(TDG)
TGE112634371(TDG)
MLEU105536205(TDG)
RRO104657468(TDG)
RBB108544252(TDG)
TFN117089512(TDG)
PTEH111524668(TDG)
CANG105506897(TDG)
CJC100398863(TDG)
SBQ101038544(TDG)
CIMI108312435(TDG)
CSYR103266485(TDG)
MMUR105875583(TDG)
LCAT123639361(TDG)
PCOQ105815112(TDG)
OGA100949300(TDG)
MMU21665(Tdg) 545124(Tdg-ps)
MCAL110289134 110302718(Tdg)
MPAH110326545(Tdg)
RNO114521(Tdg)
MCOC116075717(Tdg)
ANU117696317(Tdg) 117701718 117718032
MUN110563926(Tdg)
CGE100752484 100771878 100772748(Tdg)
MAUA101828697(Tdg) 101833826 121133556
PROB127237817(Tdg)
PLEU114686948 114700613(Tdg)
MORG121456618(Tdg)
MFOT126503755
AAMP119803301(Tdg)
NGI103742144(Tdg)
HGL101703457(Tdg)
CPOC100724604(Tdg)
CCAN109675720(Tdg)
DORD105990442(Tdg)
DSP122119175(Tdg)
PLOP125359285(Tdg)
NCAR124983435
MMMA107139948(Tdg) 107152259
OCU100355930
OPI101528416(TDG)
TUP102496464(TDG)
GVR103588565(TDG)
CFA475448(TDG)
CLUD112654630(TDG)
VVP112930670(TDG)
VLG121481483(TDG)
NPO129516749(TDG)
AML100478809(TDG)
UMR103676486(TDG)
UAH113256064(TDG)
UAR123780559(TDG)
ELK111142095
LLV125107936
MPUF101689547(TDG)
MNP132019306(TDG)
MLK131839349(TDG)
NVS122891456(TDG)
ORO101384203(TDG)
EJU114222990(TDG)
ZCA113922058(TDG)
MLX117998803(TDG)
NSU110578061(TDG)
LWW102750943(TDG)
FCA101082502(TDG)
PYU121040511(TDG)
PCOO112863592(TDG)
PBG122472617(TDG)
PVIV125170773(TDG)
LRUF124501717
PTG102969722(TDG)
PPAD109265430(TDG)
PUC125919495
AJU106971878
HHV120245715(TDG)
BTA517825(TDG)
BOM102268073(TDG)
BIU109559456(TDG)
BBUB102399440(TDG)
BBIS104998310(TDG)
CHX102189100(TDG)
OAS101123623(TDG)
BTAX128048482(TDG)
ODA120858643(TDG)
CCAD122423314(TDG)
MBEZ129537274(TDG)
SSC100155184(TDG)
CFR102518004(TDG)
CDK105097477(TDG)
VPC102525287(TDG)
BACU103009535(TDG)
BMUS118902863(TDG)
LVE103081678(TDG)
OOR101280342 101289555(TDG)
DLE111187909(TDG)
PCAD102989557(TDG)
PSIU116749477 116760048(TDG)
NASI112391036(TDG)
ECB100053458(TDG)
EPZ103562005(TDG)
EAI106846788(TDG)
MYB102253254(TDG)
MYD102751349(TDG)
MMYO118650277(TDG)
MLF102421436(TDG)
PKL118728358(TDG)
EFUS103289103(TDG)
MNA107545149(TDG)
DRO112321711(TDG)
SHON119002145(TDG)
AJM119060237 119060459
PDIC114513279(TDG)
PHAS123810624(TDG)
MMF118624126(TDG)
PPAM129071371(TDG)
HAI109387776(TDG)
RFQ117029039(TDG)
PALE102888665(TDG)
PGIG120614943(TDG)
PVP105310754(TDG)
RAY107501144(TDG)
MJV108395214(TDG) 118970202
TOD119247359(TDG) 119247368
SARA101542462(TDG)
SETR126011540 126022296(TDG)
LAV100671433(TDG)
TMU101341896
ETF101637963 101648943(TDG)
DNM101435767(TDG)
MDO100021839(TDG)
GAS123248922(TDG)
SHR100920398(TDG)
AFZ127537907
PCW110205665(TDG)
OAA100076258(TDG)
GGA395510(TDG)
PCOC116233250(TDG)
MGP100545972(TDG)
CJO107314745(TDG)
TPAI128073670(TDG)
LMUT125702047(TDG)
NMEL110393853(TDG)
APLA101802890(TDG)
ACYG106035893(TDG)
CATA118256860(TDG)
AFUL116490948(TDG)
TGU100222509(TDG)
LSR110473604(TDG)
SCAN103813586(TDG)
PMOA120508042(TDG)
OTC121347866(TDG)
PRUF121357739(TDG)
GFR102035597(TDG)
FAB101813146(TDG)
OMA130248585(TDG)
PHI102112018(TDG)
PMAJ107204445(TDG)
CCAE111935992(TDG)
CCW104696236(TDG)
CBRC103618197(TDG)
ETL114060737(TDG)
ZAB106629860(TDG)
ACHL103804245(TDG)
SVG106853641(TDG)
MMEA130586545(TDG)
HRT120751637(TDG)
FPG101912560(TDG)
FCH102049571(TDG)
CLV102092705(TDG) 110358245
EGZ104132738(TDG)
NNI104013372(TDG)
PCRI104024902(TDG)
PLET104623412(TDG)
EHS104503826(TDG)
PCAO104044139(TDG)
ACUN113491437(TDG)
TALA104362512(TDG)
PADL103924530(TDG)
AFOR103906507(TDG)
ACHC115352665(TDG)
HALD104315053(TDG)
HLE104831005(TDG)
AGEN126047775
GCL127029629
CCRI104155542(TDG)
CSTI104563347(TDG)
CMAC104484881(TDG)
MUI104534197(TDG)
BREG104630239(TDG)
FGA104070297(TDG)
GSTE104263949(TDG)
LDI104350564(TDG)
MNB103782225(TDG)
OHA104338290(TDG)
NNT104409832(TDG)
SHAB115605154(TDG)
DPUB104307315(TDG)
PGUU104461010(TDG)
ACAR104518552(TDG)
CPEA104396018(TDG)
AVIT104281075(TDG)
CVF104288619(TDG)
RTD128905721(TDG)
CUCA104060224(TDG)
TEO104370579(TDG)
BRHI104488362(TDG)
AAM106488729(TDG)
AROW112961527(TDG)
NPD112958395(TDG)
TGT104567765(TDG)
DNE112993925(TDG)
SCAM104147357(TDG)
ASN102368125(TDG)
AMJ102567507(TDG)
CPOO109316569(TDG)
GGN109296115(TDG)
PSS102452289(TDG)
CMY102941802(TDG)
CCAY125627499(TDG)
DCC119851667(TDG)
CPIC101935707(TDG)
TST117881386(TDG)
CABI116825963(TDG)
MRV120384328(TDG)
ACS100567264(tdg)
ASAO132775857(TDG)
PVT110084774(TDG)
SUND121931543(TDG)
PBI103058406(TDG)
PMUR107294621(TDG)
CTIG120305874(TDG)
TSR106557042(TDG)
PGUT117655388(TDG)
APRI131201671(TDG)
PTEX113455338(TDG)
NSS113432805(TDG)
VKO123028903(TDG)
PMUA114605962(TDG)
PRAF128421621(TDG)
ZVI118090779(TDG)
HCG128327658(TDG)
GJA107119987(TDG)
STOW125434731(TDG)
EMC129335832(TDG)
XLA399413(tdg.S)
XTR448432(tdg)
NPR108789008(TDG)
RTEM120932110(TDG)
BBUF120979275(TDG)
BGAR122925939(TDG)
MUO115477410(TDG)
GSH117363674(TDG)
DRE553789(tdg.1) 558951(tdg.2)
SRX107716643 107716672 107753540 107753681
SANH107665730 107665733 107679582 107679604
SGH107574736 107574747 107590837 107590866
CCAR109065141 109065142 109074826 109112013 109112014
CAUA113043271(tdg) 113043272 113066764 113095310
CGIB127946661 128013882 128013884
PTET122330353(tdg.2) 122330996(tdg.1)
LROH127156733(tdg.1) 127156735(tdg.2)
OMC131533874(tdg.2) 131534179(tdg.1)
PPRM120459009(tdg.2) 120459087(tdg.1)
RKG130085341(tdg.2) 130085343(tdg.1)
MAMB125247087(tdg.2) 125247443(tdg.1)
CIDE127507201 127507287
MASI127435649 127435651 127437705 127437706
TROS130551849(tdg.2) 130552213(tdg.1)
TDW130413758(tdg.1) 130414214(tdg.2)
MANU129433890(tdg.1) 129433892(tdg.2)
IPU108269283(tdg.1) 108269360(tdg.2)
IFU128611604(tdg.1) 128611606(tdg.2)
PHYP113546520 113546553
SMEO124386311(tdg.1) 124386322(tdg.2)
TFD113635573(tdg.2) 113636089(tdg.1)
TVC132855784(tdg.1) 132856230(tdg.2)
AMEX103043944 103045467
CMAO118806738(tdg.1) 118806740(tdg.2)
EEE113586428 113586448
CHAR105891516(tdg.1) 105891517(tdg.2)
TRU101067104 101067326
TFS130535932(tdg.1) 130535935(tdg.2)
TNGGSTEN00004540G001 GSTEN00004541G001
LCO104937569 104937575
NCC104948407 104948415
TBEN117497308(tdg.2) 117497310(tdg.1)
CGOB115010187 115010233
PGEO117448045(tdg.2) 117448600(tdg.1)
GACU117557471(tdg.2) 117557479(tdg.1)
EMAC134883473 134884219(tdg.2)
ELY117261585 117261625
EFO125887873(tdg.1) 125887916(tdg.2)
PLEP121950720 121950771
SLUC116046808(tdg.2) 116046812
ECRA117948732(tdg.1) 117949310(tdg.2)
ESP116693593 116693595
PFLV114560007 114560430
GAT120808931(tdg.2) 120809529 120812634
PPUG119196355(tdg.2) 119196410(tdg.1)
AFB129108030(tdg.2) 129108033(tdg.1)
CLUM117731821(tdg.1) 117731828(tdg.2)
PSWI130195233(tdg.2) 130195474(tdg.1)
MSAM119893480 119894164(tdg.2)
SCHU122874601 122874602
CUD121514636 121514653(tdg.2)
ALAT119023960(tdg.2) 119023961
MZE101483821 101484631
ONL100698171(tdg) 100698435
OAU116313957(tdg.2) 116313959
OLA101155844(tdg) 101162834
OML112151959 112151960
CSAI133440325 133443644(tdg.2) 133443654(tdg.1) 133444521
XMA102223318 102226852(tdg)
XCO114133528 114156867(tdg)
XHE116730895 116730915
PRET103465701 103465703(tdg)
PFOR103156558 103156561
PLAI106939000 106939003
PMEI106933967 106933969
GAF122835147(tdg.2) 122835757(tdg.1)
PPRL129367803(tdg.1) 129367892(tdg.2)
CVG107081070 107092187 107092203
CTUL119798191(tdg.1) 119798193(tdg.2)
GMU124855721(tdg.1) 124877621(tdg.2)
NFU107388368(tdg) 107388370
KMR108245713 108245718
ALIM106522812 106522814
NWH119415418(tdg.2) 119415420(tdg.1)
AOCE111567879 111567882
MCEP125014444(tdg.1) 125015296(tdg.2)
CSEM103379812 103379813
POV109624640 109624666
SSEN122776349(tdg.2) 122776371(tdg.1)
HHIP117763667(tdg.1) 117763672(tdg.2)
HSP118110123(tdg.1) 118110124(tdg.2)
SMAU118315324(tdg.2) 118315672(tdg.1)
LCF108889295(tdg.1) 108889296(tdg.2)
SDU111229630 111229702
SLAL111650459(tdg) 111650466
XGL120792658(tdg.2) 120793792(tdg.1)
HCQ109530839 109530840
SSCV125970926 125970931
SBIA133501846(tdg.1) 133501848(tdg.2)
PEE133402742(tdg.2) 133403361(tdg.1)
PTAO133478253(tdg.1) 133478255(tdg.2)
BPEC110160314 110160346
MALB109973201 109975014
BSPL114857768(tdg.1) 114857842(tdg.2)
SJO128358788(tdg.2) 128359131(tdg.1)
SASA106561084 106561087 106584662 106584663
STRU115192829 115192833 115197091(tdg) 115197093
OTW112218271 112218273(tdg.2) 112221315 112222201
OMY110492132 110492152 110521257 110521258
OGO124037006 124037008 124039580(tdg.1) 124039602
ONE115134518 115134519 115144706 115144708
OKI109867134 109867562 109897711 109897712
OKE118374273 118396407 118396411(tdg.1) 127926125
SALP111962111 111962113 111972058 111972059
SNH120052301 120052302 120066620 120066621
CCLU121532132 121532135 121540819 121540820
ELS105009540(tdg) 105009541
SFM108920955 108920957
PKI111844304 111844308 111847043
AANG118218770 118218771 118231363 118231687
LOC102682644(tdg)
PSPA121318478 121319620
ARUT117415830 117420017
PSEX120534315
LCM102350121(TDG)
CMK103179828
CPLA122559835
HOC132824863
LERI129706369
PMRN116950514
LRJ133352344
BFO118403306
BBEL109462309
CIN104266612
SCLV120338754
SPU586471
APLC110982095
DMEDmel_CG1981(Tdg)
DER6555861
DSIDsimw501_GD24378(Dsim_GD24378)
DYADyak_GE14511
DSR110185485
DPE6602004
DMN108164486
DWI6651298
DMODmoj_GI14092
DAZ108617810
DNV108655366
DHE111593706
TDA119675244 119685616
LCQ111683328
AME408649 725801
ACER107992495 107999117
ALAB122718843 122720041
ADR102672067
AFLR100870100
BIM100741428 100745769
BBIF117204817 117208381
BVK117231193 117237707
BVAN117158113 117163389
BTER100648503 100649696
BAFF126918732
BPYO122570892 122577836
BPAS132908264
FVI122530238 122530665
CCAL108626054 108626232 108627180
OBB114872787 114876182
OLG117600131 117608347
MGEN117224639 117225009
NMEA116425224 116427667
CGIG122397983
SOC105199434 105205270
MPHA105833412 105838336
AEC105153872 105154007 105154122
ACEP105618145 105622736
PBAR105424915 105427395 105427396
VEM105566649
HST105182606 105188391
DQU106746477 106752272
CFO105248080 105259395
FEX115236526 115245063
LHU105674984 105679748
PGC109855243 109858127
OBO105278771 105285578
PCF106785249 106792647
PFUC122520013 122525916
VPS122631464 122633068
VCRB124426590 124428104
VVE124952436 124953118
NVI100116130 100120200
CSOL105364184 105365644
TPRE106657129 111694519
MDL103568547 103580461
CGLO123259989 123272512
FAS105266105 105273696
DAM107037909 107048238
VCAN122410516
CCIN107269758
AROA105691155
TCA658765
DPA109541058
SOY115887130
ATD109601644
CSET123322189
AGB108906831
LDC111513469 111514412
NVL108565870
APLN108737596
PPYR116167470
OTU111419488
BMOR101735453
BMAN114248693
DPLKGM_200103
PMAC106707729
PXU106118483
PRAP110991611
ZCE119837551
AAGE121736822
HAW110382226
TNL113495872
PXY105387432 105390882 105396146
API100164619
DNX107168052
AGS114132970
RMD113555908
BTAB109044134
DCI103507244 103507245
CLEC106667760 106669980
HHAL106682041 106689665
NLU111048183
PHUPhum_PHUM302160
FOC113202449
TPAL117651747
ZNE110831912
CSEC111871104
BROR134529515
FCD110859143
DPXDAPPUDRAFT_43853
DMK116920206
DPZ124336889
PVM113800830 113821442
PJA122247745 122255942
PCHN125042755
PMOO119590054
HAME121857233 121864623
PCLA123746559
CQD128692190
PTRU123499975
ESN127004469
EAF111697897 111712809
TCF131887728
PPOI119101900
DSV119431365
RSAN119406250
RMP119163320
TUT107360226
CSCU111632264
PTEP107437527
ABRU129960525
UDV129218656
SDM118187549
LPOL111086543
TSPTsp_05734
HROHELRODRAFT_124128 HELRODRAFT_71611
LGILOTGIDRAFT_132396
PVUL126828255
PCAN112571781
BGT106070853
GAE121369243
HRF124116998
HRJ124266004
CRG105344766
CVN111109690
CANU128159896
OED125655075
MYI110448845
PMAX117331708
RPHI132715635
OBI106876312
OSN115227526
LAK106166915 106178371
SMMSmp_149220
SHXMS3_00007248
OVIT265_11500
NVE5514443
EPA110237087 110251124
ADF107349925 107358636
AMIL114953672
PDAM113685282
SPIS111325133
DGT114530645
HMG100203258 100206585
HSY130625311 130654208
TADTRIADDRAFT_6342
AQU100639845
CRECHLRE_03g180100v5
CVRCHLNCDRAFT_134530
DHADEHA2F17270g
PICPICST_55251
PGUPGUG_04234
SPAASPAPADRAFT_51743
LELPVL30_003540(thp1)
CALCAALFM_C306530WA(CaO19.7442)
CTPCTRG_05704 CTRG_05712
COTCORT_0A05590
CDUCD36_86500
CTENCANTEDRAFT_100862
YLIYALI0F04796g
CLUCLUG_04196
CLUSA9F13_04g03289
CAURCJI96_0004941
SLBAWJ20_1623
NCRNCU02098
SMPSMAC_04996
PANPODANSg09472
PBELQC761_102290(thp1)
PPSDQC762_102290(thp1)
PPSPQC763_102290(thp1)
PPSAQC764_102290(thp1)
TTTTHITE_2121304
MTMMYCTH_2019108
CTHRCTHT_0058600
MGRMGG_11518
PPEIPpBr36_08461
PGRIPgNI_08635
TMNUCRPA7_1261
SSCKSPSK_00047
FGRFGSG_00873
FPUFPSE_11649
FPOAFPOAC1_000923
FVNFVRRES_01095
FVRFVEG_00629 FVEG_08412
FOXFOXG_00833
NHENECHADRAFT_75270
FFCNCS54_00141900
FKRNCS57_00139100
FMUJ7337_001351 J7337_012927
TRETRIREDRAFT_64832
TRRM419DRAFT_43526
MAWMAC_06227
MAJMAA_00707
PCHMVFPPC_08410
CMTCCM_05432
AMUSLMH87_006103
PLJVFPFJ_09108
PTKZJDV02_009322
VALVDBG_07391
VDAVDAG_06102
CFJCFIO01_11617
CLUPCLUP02_13723
CHIGCH63R_05823
ELAUCREL1_6459
PFYPFICI_06964
SSLSS1G_05672
BFUBCIN_05g00430
MBEMBM_03404
PSCOLY89DRAFT_565894
GLZGLAREA_08425
ANIANIA_05479
AFMAFUA_6G13340
ACTACLA_086590
NFINFIA_059260
AORAO090003000458
ANGAn08g10020
AFVAFLA_001231
ALUCAKAW2_51782S
ACHEACHE_10146S
APUUAPUU_40809S
PCSN7525_006068
PDPPDIP_45790
POUPOX_a01837
TMFEYB26_002519
TRGTRUGW13939_06628
CIMCIMG_10236
CPWCPC735_013310
UREUREG_03494
PBLPAAG_04642
PBNPADG_04800
ABEARB_07552
TVETRV_07036
BGHBDBG_05233
PNOSNOG_14120
PTEPTT_08555
BZECOCCADRAFT_6753
BSCCOCSADRAFT_40835
BORCOCMIDRAFT_104028
AALTCC77DRAFT_1030286
ARABEKO05_0003814
ZTRMYCGRDRAFT_24066
PFJMYCFIDRAFT_110830
FFUCLAFUR5_04044
CBETCB0940_07926
BCOMBAUCODRAFT_64646
NPAUCRNP2_1118
TMLGSTUM_00001121001 GSTUM_00005557001
SPOSPCC965.05c(thp1)
SOMSOMG_03441(thp1)
CNECNF00820
CNBCNBF3900
CNGCNAG_05891
CGICGB_F5460C
CDEUCNBG_1656
TMSTREMEDRAFT_65863
TASAA1Q1_07383
PPLPOSPLDRAFT_101350
TVSTRAVEDRAFT_137083
DSQDICSQDRAFT_67668
PCOPHACADRAFT_203182 PHACADRAFT_203552 PHACADRAFT_259229 PHACADRAFT_266509
SHSSTEHIDRAFT_103259
HIRHETIRDRAFT_241775
ADLAURDEDRAFT_156468
FMEFOMMEDRAFT_152913
GTRGLOTRDRAFT_139869
LBCLACBIDRAFT_298866 LACBIDRAFT_303372 LACBIDRAFT_312282 LACBIDRAFT_316334 LACBIDRAFT_316355 LACBIDRAFT_316369 LACBIDRAFT_316377
CCICC1G_09247
ABPAGABI1DRAFT69564(AGABI1DRAFT_69564)
ABVAGABI2DRAFT200628(AGABI2DRAFT_200628)
MRRMoror_1803 Moror_7098
MOREE1B28_004957
SCMSCHCO_02497584(SCHCODRAFT_02497584)
CPUTCONPUDRAFT_113454
SLASERLADRAFT_456783
WSEWALSEDRAFT_47705
WICJ056_001084
UMAUMAG_10845
PFPPFL1_04534
MGLMGL_2765
PGRPGTG_07986
PTRCPtA15_3A738
MBRMONBRDRAFT_29131
SREPTSG_02460
SPARSPRG_01482
 » show all
Reference
1  [PMID:10767625]
  Authors
Waters TR, Swann PF
  Title
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
  Journal
Mutat Res 462:137-47 (2000)
DOI:10.1016/S1383-5742(00)00031-4
Reference
2  [PMID:8407958]
  Authors
Neddermann P, Jiricny J
  Title
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
  Journal
J Biol Chem 268:21218-24 (1993)
  Sequence
[hsa:6996]
Reference
3  [PMID:9685338]
  Authors
Waters TR, Swann PF
  Title
Kinetics of the action of thymine DNA glycosylase.
  Journal
J Biol Chem 273:20007-14 (1998)
DOI:10.1074/jbc.273.32.20007
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.29
IUBMB Enzyme Nomenclature: 3.2.2.29
ExPASy - ENZYME nomenclature database: 3.2.2.29
BRENDA, the Enzyme Database: 3.2.2.29

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