KEGG ENZYME: 3.3.2.13

ENZYME: 3.3.2.13

Entry

EC 3.3.2.13                 Enzyme

Name

chorismatase;
chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase;
fkbO (gene name);
rapK (gene name)

Class

Hydrolases;
Acting on ether bonds;
Ether hydrolases

Sysname

chorismate pyruvate-hydrolase

Reaction(IUBMB)

chorismate + H2O = (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate [RN:R10583]

Reaction(KEGG)

R10583

Substrate

chorismate [CPD:C00251];
H2O [CPD:C00001]

Product

(4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate [CPD:C20710];
pyruvate [CPD:C00022]

Comment

The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.

History

EC 3.3.2.13 created 2013

Pathway

ec00400

Phenylalanine, tyrosine and tryptophan biosynthesis

Orthology

K18239

chorismatase

Genes

CABK:

NK8_78160

PARZ:

DTQ13_05210

SRC:	M271_40655

SMAL:

SMALA_8314

SSOI:

I1A49_45310

SQZ:	FQU76_32190

SKA:	CP970_02280

STSU:

B7R87_01750

SROI:

IAG44_38935

SDD:	D9753_34425

SROC:

RGF97_13795

UME:	RM788_51525

ACTN:

L083_2967(rapK)

ACTR:

Asp14428_14190(rapK)

AMAS:

QU670_04540

SLOM:

PXH66_19155

LUB:	TBR22_A45260(rapK)

» show all

Reference

1 [PMID:21383123]

Authors

Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B

Title

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Journal

Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108

Sequence

[ag:AAF86394]

Reference

2 [PMID:24036425]

Authors

Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN

Title

Mechanistic implications for the chorismatase FkbO based on the crystal structure.

Journal

J Mol Biol 426:105-15 (2014)
DOI:10.1016/j.jmb.2013.09.006

Sequence

[ag:AAF86394]

Other DBs

ExplorEnz - The Enzyme Database:

3.3.2.13

IUBMB Enzyme Nomenclature:

3.3.2.13

ExPASy - ENZYME nomenclature database:

3.3.2.13

BRENDA, the Enzyme Database:

3.3.2.13

DBGET integrated database retrieval system