KEGG ENZYME: 3.3.2.15

ENZYME: 3.3.2.15

Entry

EC 3.3.2.15                 Enzyme

Name

trans-2,3-dihydro-3-hydroxyanthranilic acid synthase;
isochorismatase (ambiguous);
phzD (gene name)

Class

Hydrolases;
Acting on ether bonds;
Ether hydrolases

Sysname

(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase

Reaction(IUBMB)

(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate [RN:R11463]

Reaction(KEGG)

R11463

Substrate

(2S)-2-amino-4-deoxychorismate [CPD:C18054];
H2O [CPD:C00001]

Product

(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate [CPD:C19830];
pyruvate [CPD:C00022]

Comment

Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.

History

EC 3.3.2.15 created 2016

Pathway

ec00405

Phenazine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20261

trans-2,3-dihydro-3-hydroxyanthranilic acid synthase

Genes

KGR:	JJJ10_13560

KPAS:

LUW96_21805

KLM:	BWI76_15095

SFW:	WN53_03390

ECA:	ECA2702(ehpB)

PATR:

EV46_13200

PATO:

GZ59_18580(ehpB)

PPAV:

LOZ86_13700

PACB:

M9782_10865

LAB:	LA76x_3334(phzD1)

LAQ:	GLA29479_2367(phzD1)

VRU:	RND59_08000

PAE:	PA1902(phzD2) PA4213(phzD1)

PAEV:

N297_1962 N297_4345

PAEI:

N296_1962 N296_4345

PAU:	PA14_09450(phzD1) PA14_39925(phzD2)

PAP:	PSPA7_0886 PSPA7_3382

PAG:	PLES_07141(phzD1) PLES_34221(phzD2)

PAF:	PAM18_0724(phzD1) PAM18_3140(phzD2)

PAEB:

NCGM1900_4587

PDK:	PADK2_03605 PADK2_16140

PSG:	G655_03640 G655_15605

PRP:	M062_22195

PAEP:

PA1S_03755 PA1S_16430

PAER:

PA1R_gp2104 PA1R_gp5531

PAEM:

U769_03785 U769_16145

PAEL:

T223_03690 T223_17490

PAES:

SCV20265_0748 SCV20265_3493

PAEU:

BN889_06463(phzD1_1) BN889_06777(phzD1_3) BN889_07359(phzD1_6)

PAEG:

AI22_00155 AI22_17560

PAEC:

M802_1960 M802_4343

PAEO:

M801_1961 M801_4211

PPAA:

B7D75_03685 B7D75_15430

PAST:

N015_20085

PFB:

VO64_0337

POI:	BOP93_12305

PCH:	EY04_26285

PCP:	JM49_05460

PCHP:

C4K32_5262

PSET:

THL1_3621

PYM:	AK972_2556

PSEP:

C4K39_3098

PPII:

QL104_15640

BUU:	WS70_27180

BUR:	Bcep18194_B1569

BGL:	bglu_2g09250

BGU:

KS03_4992

TVL:	FAZ95_31780

RUG:	QC826_13640

BVR:

BVIR_2863

SECH:

B18_04210 B18_21400

MAB:

MAB_0297

MMV:	MYCMA_0159

MABB:

MASS_0298

MABL:

MMASJCM_0294

MCHE:

BB28_01465

MIZ:	BAB75_02015

MSAO:

MYCSP_01295

MSAL:

DSM43276_00252(phzD_1)

CMV:	CMUST_14535

NBR:	O3I_033280

NAH:	F5544_33425

NHU:	H0264_16225

RFA:	A3L23_00644(phzD)

RHS:	A3Q41_02711(phzD)

TPR:

Tpau_0113

SALB:

XNR_0597

SFI:	SFUL_3324 SFUL_5262

SGRF:

SGFS_036810

SCYE:

R2B67_04370

SCB:	SCAB_12041

SSX:	SACTE_1752

SALS:

SLNWT_4919

SGU:	SGLAU_17220(phzA)

STRM:

M444_18420

STRC:

AA958_30770

SCZ:	ABE83_19210 ABE83_26415

SRN:	A4G23_05417(phzD)

STRT:

A8713_24035

SGM:	GCM10017557_24350(phzD1)

SCAD:

DN051_13635 DN051_37360

SLS:	SLINC_5468

SPLU:

LK06_026280

STRD:

NI25_24440

SNW:	BBN63_05570

SALJ:

SMD11_1729 SMD11_3253

SQZ:	FQU76_00255 FQU76_33485

SAST:

CD934_07145

SGZ:	C0216_00425

SVN:	CP980_14880

SRK:	FGW37_24780

SVR:	CP971_17430

SPAD:

DVK44_32315

SCAV:

CVT27_15340

SSEO:

D0Z67_01715

SCIN:

CP977_15855

SFUG:

CNQ36_29865

SSPB:

CP982_28280

SHUN:

DWB77_04281(phzD)

SLIA:

HA039_29910

SFB:	CP974_28840

SROI:

IAG44_13945 IAG44_38380

STRY:

EQG64_08385 EQG64_16160

SMAO:

CAG99_00490 CAG99_15050

SLF:	JEQ17_03405

SNIG:

HEK616_55590(phzD1)

SCAE:

IHE65_08535

STUD:

STRTU_005062

STEE:

F3L20_15980

SGK:	PET44_17175

SCYN:

N8I84_14850 N8I84_30915

SHAU:

K9S39_36110

SKG:	KJK29_05880

SCOA:

QU709_14165

SCHG:

NRO40_23340 NRO40_27020

SINN:

ABB07_25525

KSK:	KSE_58300 KSE_59070

KAU:	B6264_12425

KIT:	CFP65_3611

STRI:

C7M71_014740

ABRY:

NYE86_21255

FRP:	AX769_15030

RTER:

IDM49_10735

RAMA:

IDM48_01840

CEZ:	CBP52_12015

CPAL:

F1D97_01435

THAO:

NI17_009045

TALX:

FOF52_08960 FOF52_14760

NDA:

Ndas_5030

NEX:	NE857_18250

NAKE:

KGD83_26655

NCG:	KGD84_13385

STRR:

EKD16_18440(phzD)

ACTW:

F7P10_05705

NOA:	BKM31_19750

NGN:	LCN96_24510

MHAI:

OHB01_22665

FRE:	Franean1_3619

SACG:

FDZ84_16255

AMYC:

CU254_36750

PHH:	AFB00_28930

APRE:

CNX65_15955

SSYI:

EKG83_21240

KUT:	JJ691_21740

KBU:	Q4V64_42955

KPHY:

AOZ06_22495 AOZ06_25085

ALO:

CRK58740

ACTU:

Actkin_02707(dhbB_2) Actkin_02796(phzD)

MICB:

MicB006_2898

MICH:

FJK98_01250

MSAG:

GCM10017556_11840

MCHL:

PVK74_09445

PFLA:

Pflav_059760

PSUU:

Psuf_020500 Psuf_091090

PRY:	Prubr_64680(phzD1)

DFU:	Dfulv_24065

DROS:

Drose_22850

DMAT:

Dmats_35165

GLY:	K3N28_00720

ACTC:

CHIBA101_0087

AEY:	CDG81_16850

» show all

Reference

1 [PMID:11591691]

Authors

Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS

Title

Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.

Journal

J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001

Sequence

[pae:PA1902 PA4213]

Reference

2 [PMID:12741825]

Authors

Parsons JF, Calabrese K, Eisenstein E, Ladner JE

Title

Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.

Journal

Biochemistry 42:5684-93 (2003)
DOI:10.1021/bi027385d

Sequence

[pae:PA1902]

Other DBs

ExplorEnz - The Enzyme Database:

3.3.2.15

IUBMB Enzyme Nomenclature:

3.3.2.15

ExPASy - ENZYME nomenclature database:

3.3.2.15

BRENDA, the Enzyme Database:

3.3.2.15

DBGET integrated database retrieval system