KEGG   ENZYME: 3.3.2.2
Entry
EC 3.3.2.2                  Enzyme                                 
Name
lysoplasmalogenase;
alkenylglycerophosphocholine hydrolase;
alkenylglycerophosphoethanolamine hydrolase;
1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
lysoplasmalogen aldehydohydrolase
Reaction(IUBMB)
(1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine [RN:R02745];
(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine [RN:R03415]
Reaction(KEGG)
R02745 R03415
Substrate
1-(1-alkenyl)-sn-glycero-3-phosphocholine [CPD:C04517];
H2O [CPD:C00001];
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine [CPD:C04635]
Product
aldehyde [CPD:C00071];
sn-glycero-3-phosphocholine [CPD:C00670];
sn-glycero-3-phosphoethanolamine [CPD:C01233]
Comment
Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine.
History
EC 3.3.2.2 created 1972, modified 1976, (EC 3.3.2.5 created 1984, incorporated 2016), modified 2016
Pathway
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K18575  alkenylglycerophosphocholine hydrolase
Genes
HSA: 255043(TMEM86B)
PTR: 456297(TMEM86B)
PPS: 100985350(TMEM86B)
GGO: 101134478(TMEM86B)
PON: 100448045(TMEM86B)
NLE: 100597527(TMEM86B)
HMH: 116479213(TMEM86B)
MCC: 699222(TMEM86B)
MCF: 102126102(TMEM86B)
MTHB: 126943227
MNI: 105488185(TMEM86B) 105496970
CSAB: 103235296(TMEM86B)
CATY: 105582748(TMEM86B)
PANU: 101016665(TMEM86B)
TGE: 112613172(TMEM86B)
MLEU: 105551624(TMEM86B)
RRO: 104674761(TMEM86B)
RBB: 108542528(TMEM86B)
TFN: 117091731(TMEM86B)
PTEH: 111521208(TMEM86B)
CANG: 105504868(TMEM86B)
CJC: 100388681(TMEM86B)
SBQ: 101047356(TMEM86B)
CIMI: 108316613(TMEM86B)
CSYR: 103267499(TMEM86B)
MMUR: 105877200(TMEM86B)
LCAT: 123624694(TMEM86B)
PCOQ: 105809399(TMEM86B)
OGA: 100940373(TMEM86B)
MMU: 68255(Tmem86b)
MCAL: 110297428(Tmem86b)
MPAH: 110336976(Tmem86b)
RNO: 690610(Tmem86b)
MCOC: 116101553(Tmem86b)
ANU: 117701039(Tmem86b)
MUN: 110561057(Tmem86b)
CGE: 100771800(Tmem86b)
MAUA: 101829923(Tmem86b)
PROB: 127238424(Tmem86b)
PLEU: 114687716(Tmem86b)
MORG: 121449985(Tmem86b)
MFOT: 126493648
NGI: 103744859(Tmem86b)
HGL: 101720540(Tmem86b)
CPOC: 100713815(Tmem86b)
CCAN: 109696265(Tmem86b)
DORD: 105999526(Tmem86b)
DSP: 122110566(Tmem86b)
PLOP: 125368321(Tmem86b)
NCAR: 124966927
MMMA: 107158934(Tmem86b)
OCU: 100354255
OPI: 101532485(TMEM86B)
TUP: 102498612(TMEM86B)
GVR: 103594709(TMEM86B)
CFA: 611345(TMEM86B)
CLUD: 112644999(TMEM86B)
VVP: 112909324(TMEM86B)
VLG: 121484888(TMEM86B)
NPO: 129500473(TMEM86B)
AML: 100477670(TMEM86B)
UMR: 103680265(TMEM86B)
UAH: 113247424(TMEM86B)
UAR: 123786947(TMEM86B)
ELK: 111139581
LLV: 125089168
MPUF: 101675822(TMEM86B)
MNP: 132004762(TMEM86B)
MLK: 131817923(TMEM86B)
NVS: 122912184(TMEM86B)
ORO: 101385614(TMEM86B)
EJU: 114202041(TMEM86B)
ZCA: 113935875(TMEM86B)
MLX: 117998002(TMEM86B)
NSU: 110573613(TMEM86B)
LWW: 102729502(TMEM86B)
FCA: 101092067(TMEM86B)
PYU: 121023434(TMEM86B)
PCOO: 112851138(TMEM86B)
PBG: 122493738(TMEM86B)
LRUF: 124527796
PTG: 102961296(TMEM86B)
PPAD: 109259907(TMEM86B)
PUC: 125915584
AJU: 106980918
HHV: 120239689(TMEM86B)
BTA: 518466(TMEM86B)
BOM: 102265175(TMEM86B)
BIU: 109571855(TMEM86B)
BBUB: 102415924(TMEM86B)
BBIS: 104986700(TMEM86B)
CHX: 102186626(TMEM86B)
OAS: 101121701(TMEM86B)
BTAX: 128063699(TMEM86B)
ODA: 120871905(TMEM86B)
CCAD: 122420328(TMEM86B)
MBEZ: 129546029(TMEM86B)
SSC: 100514582(TMEM86B)
CFR: 102512804(TMEM86B)
CBAI: 105074357(TMEM86B)
CDK: 105098739(TMEM86B)
VPC: 102545779(TMEM86B)
BACU: 103006787(TMEM86B)
LVE: 103082812(TMEM86B)
OOR: 101275562(TMEM86B)
DLE: 111181022(TMEM86B)
PCAD: 102985211(TMEM86B)
PSIU: 116743851(TMEM86B)
NASI: 112406395(TMEM86B)
ECB: 100055488(TMEM86B)
EPZ: 103562865(TMEM86B)
EAI: 106840930(TMEM86B)
MYB: 102239470 102239989
MYD: 102757075(TMEM86B)
MMYO: 118655176 118655183(TMEM86B)
PKL: 118715920 118715921
EFUS: 103304202 129147517
MNA: 107541331(TMEM86B)
DRO: 112313458(TMEM86B)
SHON: 118981342(TMEM86B)
AJM: 119059981(TMEM86B)
PDIC: 114510568(TMEM86B)
PHAS: 123813339(TMEM86B)
MMF: 118639534(TMEM86B)
PPAM: 129082517(TMEM86B)
HAI: 109373772(TMEM86B)
RFQ: 117035309(TMEM86B)
PALE: 102878082(TMEM86B)
PGIG: 120598353(TMEM86B)
PVP: 105304915(TMEM86B)
RAY: 107515388(TMEM86B)
MJV: 108388698(TMEM86B)
TOD: 119250477(TMEM86B)
SARA: 101537235(TMEM86B)
LAV: 100671261(TMEM86B)
TMU: 101361536
ETF: 101650196(TMEM86B)
DNM: 101418852(TMEM86B)
MDO: 103100945(TMEM86B)
GAS: 123255783(TMEM86B)
SHR: 116422152(TMEM86B)
AFZ: 127556703
PCW: 110192255 110220258(TMEM86B)
ASN: 102387730(TMEM86B)
AMJ: 102558009(TMEM86B)
CPIC: 101933306 103307009
DRE: 751651(tmem86b)
SRX: 107731175 107755106
SANH: 107653546 107690344
SGH: 107560751 107567558
CCAR: 109048083
CAUA: 113043434 113047635
CGIB: 127942885
PTET: 122335762(tmem86b)
LROH: 127156910(tmem86b)
OMC: 131536402(tmem86b)
PPRM: 120489067(tmem86b)
RKG: 130075239(tmem86b)
MAMB: 125279474(tmem86b)
CIDE: 127508699
MASI: 127450510 127451608
TROS: 130561958(tmem86b)
TDW: 130425724(tmem86b)
MANU: 129436259(tmem86b)
IPU: 108256452(tmem86b)
IFU: 128601815(tmem86b)
PHYP: 113528449
SMEO: 124397009(tmem86b)
TFD: 113641176(tmem86b)
TVC: 132860590(tmem86b)
AMEX: 103023220
CMAO: 118821600(tmem86b)
EEE: 113589869
CHAR: 105894963(tmem86b)
TRU: 105416426
TFS: 130514430(tmem86b)
TNG: GSTEN00021889G001
LCO: 109142467
NCC: 104942715
TBEN: 117492404(tmem86b)
CGOB: 115011617
PGEO: 117451629(tmem86b)
GACU: 117544108(tmem86b)
EMAC: 134877935(tmem86b)
ELY: 117268781(tmem86b)
EFO: 125880009(tmem86b)
PLEP: 121956671(tmem86b)
SLUC: 116065319(tmem86b)
ECRA: 117957504(tmem86b)
ESP: 116703764
PFLV: 114568966
GAT: 120827240(tmem86b)
PPUG: 119220139(tmem86b)
AFB: 129098073 129098103(tmem86b)
CLUM: 117734507(tmem86b)
PSWI: 130188418(tmem86b)
MSAM: 119886628(tmem86b)
CUD: 121504018(tmem86b)
ALAT: 119013377(tmem86b)
MZE: 101486306
ONL: 100694713
OAU: 116314611(tmem86b)
OLA: 101155934
OML: 112141805(tmem86b)
CSAI: 133422457(tmem86b)
XMA: 102233773
XCO: 114160008
XHE: 116735652
PRET: 103469090
PFOR: 103145416(tmem86b)
PLAI: 106951624(tmem86b)
PMEI: 106931192(tmem86b)
GAF: 122822357(tmem86b)
PPRL: 129363295(tmem86b)
CVG: 107095140(tmem86b)
CTUL: 119781684(tmem86b)
GMU: 124863035 124864057(tmem86b)
NFU: 107376661(tmem86b)
KMR: 108242939(tmem86b)
ALIM: 106528140(tmem86b)
NWH: 119422206(tmem86b)
AOCE: 111565373
MCEP: 124997533(tmem86b) 124997534 124997535
CSEM: 103392979
SSEN: 122785101(tmem86b)
HHIP: 117766761(tmem86b)
HSP: 118123978(tmem86b)
SMAU: 118288715(tmem86b)
LCF: 108881012(tmem86b)
SDU: 111230304
SLAL: 111649096
XGL: 120807594(tmem86b)
HCQ: 109514858
SSCV: 125984170
SBIA: 133514315(tmem86b)
PEE: 133414517(tmem86b)
PTAO: 133465587(tmem86b)
MALB: 109958883
BSPL: 114860841(tmem86b)
SJO: 128378740(tmem86b)
SASA: 106606413
STRU: 115171865 115207629
OTW: 112237781(tmem86b)
OMY: 110487446 118937787
OGO: 124020630(tmem86b)
ONE: 115127895
OKI: 109876544
OKE: 118380345
SNH: 120043783(tmem86b)
CCLU: 121551580 123482640
ELS: 109614544
SFM: 108941811
PKI: 111836845
AANG: 118216524(tmem86b)
PSPA: 121306009(tmem86b)
PSEX: 120542787(tmem86b)
MSEX: 115442432
DPL: KGM_204626B
NIQ: 126776706
MCIX: 123662854
PPOT: 106107730
PNAP: 125056488
LSIN: 126978058
TNL: 113500329
SLIU: 111354585
OFU: 114358899
PGW: 126375572
PMY: Pmen_1483
PMK: MDS_1539
PPSE: BN5_2891
PALC: A0T30_08600
PCQ: PcP3B5_48920
PPG: PputGB1_3690
PPT: PPS_3515
PPUH: B479_17505
PPUN: PP4_16380
PPUD: DW66_3961
PMON: X969_16805
PMOT: X970_16455
PFL: PFL_4925
PPRC: PFLCHA0_c49080
PFE: PSF113_1051
PFN: HZ99_11670
PFS: PFLU_1068
PFC: PflA506_1051
PFB: VO64_4195
PMAN: OU5_4684
PTV: AA957_08645
PVR: PverR02_05605
PAZO: AYR47_12640
PRX: HRH33_06185
PTOL: I7845_05455
PFW: PF1751_v1c10260
PFF: PFLUOLIPICF703005
PFX: A7318_04670
PBA: PSEBR_a983
PBC: CD58_05615
PPUU: PputUW4_00986
PSV: PVLB_15595
PSK: U771_06495
PKC: PKB_1429
PCH: EY04_25080
PCP: JM49_06605
PPSY: AOC04_01555
PSOS: POS17_4904
PANR: A7J50_1075
PSIL: PMA3_24060
PYM: AK972_4922
PALL: UYA_07770
PUM: HGP31_05480
POJ: PtoMrB4_16110
PPSH: G5J76_07630
PSEJ: HNQ25_17010
PVK: EPZ47_05365
PBZ: GN234_13020
PKH: JLK41_07675
PTY: JWV26_18070
PMAO: PMYSY11_1452
PTRT: HU722_0006555
PSAM: HU731_021450
PSHH: HU773_022575
PASG: KSS96_06030
PWZ: J7655_14285
PTAE: NCTC10697_00944
PHF: NLY38_17725
PPEG: KUA23_05560
PHYG: JTY93_21375
PCHE: QYM18_15140
PPAE: LDL65_16635
OSG: BST96_19045
SHD: SUTH_02011
BDA: FSZ17_22675
VIR: X953_18400
VHL: BME96_17885
VPN: A21D_01725
BSJ: UP17_24770
BMUR: ABE28_023510
PBUT: DTO10_11405
PPSR: I6J18_14935
BVQ: FHE72_05150
BVJ: I5776_05090
BBEV: BBEV_0249
GYM: GYMC10_4649
PVO: PVOR_25011
PLW: D5F53_06940
PRZ: GZH47_23895
PLYC: GXP70_22650
PLAY: DNR44_011900
ACIT: HPK19_17355
AOK: A3BBH6_28030
 » show all
Reference
1  [PMID:13783189]
  Authors
WARNER HR, LANDS WE.
  Title
The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether.
  Journal
J Biol Chem 236:2404-9 (1961)
Reference
2  [PMID:17805898]
  Authors
Ellingson JS, Lands WE
  Title
Phospholipid reactivation of plasmalogen metabolism.
  Journal
Lipids 3:111-20 (1968)
DOI:10.1007/BF02531727
Reference
3  [PMID:7239443]
  Authors
Gunawan J, Debuch H.
  Title
Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes.
  Journal
Hoppe Seylers Z Physiol Chem 362:445-52 (1981)
DOI:10.1515/bchm2.1981.362.1.445
Reference
4  [PMID:3753461]
  Authors
Arthur G, Page L, Mock T, Choy PC.
  Title
The catabolism of plasmenylcholine in the guinea pig heart.
  Journal
Biochem J 236:475-80 (1986)
DOI:10.1042/bj2360475
Reference
5  [PMID:21515882]
  Authors
Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz MS
  Title
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.
  Journal
J Biol Chem 286:24916-30 (2011)
DOI:10.1074/jbc.M111.247163
  Sequence
[hsa:255043]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.2
IUBMB Enzyme Nomenclature: 3.3.2.2
ExPASy - ENZYME nomenclature database: 3.3.2.2
BRENDA, the Enzyme Database: 3.3.2.2
CAS: 37288-65-6

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (402)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (369)   
   KEGG MGENES (20)   
   RefGene (12)   
Protein sequence (1954)   
   UniProt (1925)   
   SWISS-PROT (12)   
   RefSeq(pep) (17)   
DNA sequence (28)   
   RefSeq(nuc) (18)   
   GenBank (6)   
   EMBL (4)   
Protein domain (1)   
   InterPro (1)   
All databases (2398)   

Download RDF
DBGET integrated database retrieval system