Entry
Name
aminopeptidase Y;
aminopeptidase Co;
aminopeptidase (cobalt-activated);
lysyl aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferentially, release of N-terminal lysine
Comment
Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28
History
EC 3.4.11.15 created 1989, modified 1997
Orthology
Genes
NCS : NCAS_0B07580(NCAS0B07580)
NDI : NDAI_0B04920(NDAI0B04920)
TPF : TPHA_0I01120(TPHA0I01120)
TBL : TBLA_0C02710(TBLA0C02710)
TDL : TDEL_0D01650(TDEL0D01650)
KAF : KAFR_0A03620(KAFR0A03620)
KNG : KNAG_0C01650(KNAG0C01650)
CAL : CAALFM_C208800CA(APE3)
PAN : PODANSg1533 PODANSg1579
CTHR : CTHT_0037000 CTHT_0050060
TMN : UCRPA7_2183 UCRPA7_292 UCRPA7_8511
FGR : FGSG_06527 FGSG_06545
FPU : FPSE_01712 FPSE_01730
FVR : FVEG_05601 FVEG_05619
FOX : FOXG_02417 FOXG_02433
NHE : NECHADRAFT_60585 NECHADRAFT_93056
FFC : NCS54_00613900 NCS54_00615900
TRE : TRIREDRAFT_81070 TRIREDRAFT_81087
TRR : M419DRAFT_111063 M419DRAFT_111088
AMUS : LMH87_003082 LMH87_008303
PLJ : VFPFJ_10537 VFPFJ_11514
VAL : VDBG_01281 VDBG_09096
CFJ : CFIO01_00127 CFIO01_05349 CFIO01_11238
SAPO : SAPIO_CDS2153 SAPIO_CDS5260
ELA : UCREL1_1439 UCREL1_4559
BFU : BCIN_15g01050(Bcape3)
PNO : SNOG_13567(SNOG_13566)
» show all
Taxonomy
Reference
Authors
Achstetter T, Ehmann C, Wolf DH.
Title
Aminopeptidase Co, a new yeast peptidase.
Journal
Reference
Authors
Yasuhara T, Nakai T, Ohashi A
Title
Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.
Journal
J Biol Chem 269:13644-50 (1994)
Sequence
Reference
Authors
Nishizawa M, Yasuhara T, Nakai T, Fujiki Y, Ohashi A
Title
Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase.
Journal
J Biol Chem 269:13651-5 (1994)
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.11.15