Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on Glu!Trp, Leu!Trp and a number of other dipeptides
Comment
A glycoprotein containing Zn2+, from renal and intestinal brush border membranes. In peptidase family M9.
Proteins of the kidney microvillar membrane. The 130 kDa protein in pig kidney, recognized by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity.
