KEGG ENZYME: 3.4.11.22

ENZYME: 3.4.11.22

Entry

EC 3.4.11.22                Enzyme

Name

aminopeptidase I;
aminopeptidase III;
aminopeptidase yscI (gene name);
leucine aminopeptidase IV;
yeast aminopeptidase I

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases

Reaction(IUBMB)

Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates

Comment

A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18

History

EC 3.4.11.22 created 1997

Orthology

K01268

aminopeptidase I

Genes

SCE:	YKL103C(APE1)

SEUB:

DI49_3273

SPAO:

SPAR_K01100

AGO:	AGOS_ABL035C

ERC:

Ecym_7393

KLA:	KLLA0_F13574g

KMX:	KLMA_20156(LAP4)

LTH:	KLTH0D05544g

VPO:	Kpol_431p10

ZRO:	ZYRO0G03344g

CGR:	CAGL0K08536g

NCS:	NCAS_0A05740(NCAS0A05740)

NDI:	NDAI_0K02710(NDAI0K02710)

TPF:	TPHA_0G03190(TPHA0G03190)

TBL:	TBLA_0I01160(TBLA0I01160)

TGB:	HG536_0A04090

TDL:	TDEL_0A02540(TDEL0A02540)

KAF:	KAFR_0D03190(KAFR0D03190)

KNG:	KNAG_0A06510(KNAG0A06510)

ZMK:	HG535_0D03390

PPA:	PAS_chr3_0803

DHA:	DEHA2F19096g DEHA2G02354g

PIC:	PICST_36090 PICST_47494

PGU:	PGUG_00246 PGUG_00667

SPAA:

SPAPADRAFT_61203 SPAPADRAFT_62038

LEL:	PVL30_003592(APE1) PVL30_004516(LAP4)

CAL:	CAALFM_C302170CA(LAP41) CAALFM_C503590WA(LAP4)

CTP:	CTRG_02402 CTRG_05533

COT:	CORT_0E06480 CORT_0F01780

CDU:	CD36_53340 CD36_82150

CTEN:

CANTEDRAFT_114626 CANTEDRAFT_114712

YLI:	YALI0C10494g YALI0F20592g

CLU:	CLUG_02667 CLUG_03302

CLUS:

A9F13_01g08910 A9F13_07g01903

CAUR:

CJI96_0000482

SLB:	AWJ20_2140(APE1) AWJ20_3899(APE1)

SLUD:

SCDLUD_003934

NCR:

NCU04192

NTE:	NEUTE1DRAFT75349(NEUTE1DRAFT_75349)

SMP:	SMAC_04402

PAN:	PODANSg8736

PBEL:

QC761_208840(LAP4)

PPSD:

QC762_208840(LAP4)

PPSP:

QC763_208840(LAP4)

PPSA:

QC764_208840(LAP4)

TTT:	THITE_2061958

MTM:	MYCTH_2301014

CTHR:

CTHT_0065300

MGR:

MGG_07536

PPEI:

PpBr36_02447

PGRI:

PgNI_01971

TMN:	UCRPA7_5870

SSCK:

SPSK_07290

FGR:	FGSG_06133

FPU:	FPSE_00893

FPOA:

FPOAC1_009113

FVN:	FVRRES_09739

FVR:	FVEG_04770

FOX:	FOXG_07850

NHE:	NECHADRAFT_48635

FFC:	NCS54_01157900

FKR:	NCS57_01148200

FMU:	J7337_006805

TRE:	TRIREDRAFT_47127

TRR:	M419DRAFT_129298

MAW:

MAC_05085

MAJ:

MAA_08385

PCHM:

VFPPC_05959

CMT:

CCM_03061

AMUS:

LMH87_002676 LMH87_008552

PLJ:	VFPFJ_08117

PTKZ:

JDV02_004976(LAP4)

VDA:	VDAG_05108

CFJ:	CFIO01_01316

CLUP:

CLUP02_07390

CHIG:

CH63R_03792

SAPO:

SAPIO_CDS4088

ELA:	UCREL1_825

PFY:	PFICI_09596

SSL:	SS1G_01464

BFU:	BCIN_02g00170(Bcape1)

MBE:

MBM_02737

PSCO:

LY89DRAFT_584072

GLZ:	GLAREA_06492

ANI:	ANIA_11070

AFM:	AFUA_5G03990

ACT:	ACLA_001190

NFI:	NFIA_038130

AOR:	AO090102000599

ANG:	An09g06250

AFV:	AFLA_012032

ALUC:

AKAW2_40626A

ACHE:

ACHE_60794A

APUU:

APUU_60596A

PCS:	N7525_004974

PDP:	PDIP_53680

POU:	POX_a00441

TMF:	EYB26_004396

TRG:	TRUGW13939_08287

CIM:	CIMG_06637

CPW:	CPC735_030920

URE:	UREG_03805

PBL:	PAAG_04205

PBN:	PADG_07460

ABE:

ARB_06983

TVE:

TRV_00340

AJE:	HCAG_00603

BGH:	BDBG_01282

PNO:	SNOG_11059

PTE:

PTT_10165

BZE:	COCCADRAFT_92436

BSC:	COCSADRAFT_82527

BOR:	COCMIDRAFT_4161

AALT:

CC77DRAFT_1067065

ARAB:

EKO05_0010166

ZTR:	MYCGRDRAFT_75118

PFJ:	MYCFIDRAFT_32616

FFU:	CLAFUR5_07190

CBET:

CB0940_09295

BCOM:

BAUCODRAFT_74522

NPA:	UCRNP2_372

SHS:	STEHIDRAFT_166950

» show all

Reference

Authors

Johnson, M.J.

Title

Isolation and properties of a pure yeast polypeptidase.

Journal

J Biol Chem 137:575-586 (1941)

Reference

2 [PMID:5147]

Authors

Metz G, Rohm KH.

Title

Yeast aminopeptidase I. Chemical composition and catalytic properties.

Journal

Biochim Biophys Acta 429:933-49 (1976)
DOI:10.1016/0005-2744(76)90338-7

Reference

3 [PMID:2651436]

Authors

Chang YH, Smith JA

Title

Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.

Journal

J Biol Chem 264:6979-83 (1989)

Sequence

[sce:YKL103C]

Reference

4 [PMID:8601598]

Authors

Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ.

Title

Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.

Journal

J Cell Biol 132:999-1010 (1996)
DOI:10.1083/jcb.132.6.999

Other DBs

ExplorEnz - The Enzyme Database:

3.4.11.22

IUBMB Enzyme Nomenclature:

3.4.11.22

ExPASy - ENZYME nomenclature database:

3.4.11.22

BRENDA, the Enzyme Database:

3.4.11.22

CAS:

9031-94-1

DBGET integrated database retrieval system