Entry
Name
Xaa-Pro dipeptidyl-peptidase;
X-prolyl dipeptidyl aminopeptidase;
PepX;
X-prolyl dipeptidyl peptidase;
X-Pro dipeptidyl-peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolyses Xaa-Pro! bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro!p-nitroanilide and (sequentially) Tyr-Pro!Phe-Pro!Gly-Pro!Ile
Comment
The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. The reaction is similar to that catalysed by dipeptidyl-peptidase IV of animals
History
EC 3.4.14.11 created 1996
Orthology
K01281 X-Pro dipeptidyl-peptidase
Genes
BPM : BURPS1710b_A1100(pepX) BURPS1710b_A2222(pepX)
BPL : BURPS1106A_A0882 BURPS1106A_A2707
BPD : BURPS668_A0974 BURPS668_A2859
BPZ : BP1026B_II0723 BP1026B_II2138
BPQ : BPC006_II0929 BPC006_II2669
BPSH : DR55_4696 DR55_5737
BPSO : X996_3838 X996_5540
BSTL : BBJ41_20885 BBJ41_25765
BARI : NLX30_25340 NLX30_30665
BGD : bgla_2g01640 bgla_2g09120
BON : A361_04350 A361_23380
CFIR : NAF01_04100 NAF01_21045
BDA : FSZ17_18520 FSZ17_21175
VIR : X953_15895 X953_16070
NMK : CHR53_03055 CHR53_11730
NNV : QNH39_03045 QNH39_06585 QNH39_06605 QNH39_11800
SPZ : M5005_Spy1577(pepXP)
SPYM : M1GAS476_1657(pepXP)
SPH : MGAS10270_Spy1644(pepXP)
SPI : MGAS10750_Spy1635(pepXP)
SPJ : MGAS2096_Spy1602(pepXP)
SPK : MGAS9429_Spy1582(pepXP)
STG : MGAS15252_1420(pepXP)
STX : MGAS1882_1481(pepXP)
STZ : SPYALAB49_001567(pepX)
SNV : SPNINV200_08180(pepXP)
SNC : HMPREF0837_11596(pepX)
SPNE : SPN034156_18500(pepXP)
SPNU : SPN034183_08020(pepXP)
SPNM : SPN994038_07910(pepXP)
SPNO : SPN994039_07920(pepXP)
SMC : SmuNN2025_1563(pepX)
SSB : SSUBM407_0181(pepXP)
SGO : SGO_0234(pepX) SGO_1415
SGG : SGGBAA2069_c19090(pepX)
SCP : HMPREF0833_10726 HMPREF0833_10729 HMPREF0833_11237(pepX)
SCF : Spaf_1293 Spaf_1296 Spaf_1833(pepX)
SSAH : HSISS4_01580(pepXP)
SOI : I872_03475 I872_09075
SIG : N596_03790 N596_03920 N596_03935 N596_06105
SIP : N597_05795 N597_07975
STRA : ATM98_03625 ATM98_05915
SKI : D7D50_04425 D7D50_06730 D7D50_06745 D7D50_06875
SVB : NCTC12167_01619(pepXP)
SMEN : SAMEA4412692_2223(pepX)
SFER : NCTC12278_01655(pepX)
SCAI : NCTC12191_00880(pepX)
SPSU : NCTC13786_01470(pepXP)
SPOC : NCTC10925_01686(pepXP)
SLAT : J4854_06790 J4854_09180
SAUP : NCTC3168_01001(pepX_1) NCTC3168_01455(pepX_2) NCTC3168_01458(pepX_3) NCTC3168_01484(pepX_4)
SURN : NCTC13766_00348(pepX)
SVF : NCTC3166_01264(pepX_1) NCTC3166_01290(pepX_2) NCTC3166_01293(pepX_3) NCTC3166_01747(pepX_4)
SMIE : NCTC11169_00156(pepX)
SRUN : LPB404_06860 LPB404_09440
LPW : LpgJCM5343_06090(pepXP)
LOR : AYI71_00315 AYI71_10290
LBN : LBUCD034_0447(pepx1) LBUCD034_1936(pepx3)
LPAR : FAM21731_00553 FAM21731_01576
LKF : DNL43_03230 DNL43_07880
LJI : ELX58_01110 ELX58_02255 ELX58_03265
FHM : R0V13_07095 R0V13_07215
ETM : CE91St48_17560(pepX)
PHX : KGNDJEFE_00176(pepX)
SCB : SCAB_13321 SCAB_18871
SVL : Strvi_2833 Strvi_3953
SRC : M271_05715 M271_11340
SMAL : SMALA_6317 SMALA_7261
SSOI : I1A49_35450 I1A49_40070
SLE : sle_10830(sle_10830)
SGM : GCM10017557_11660(pepX)
SAUO : BV401_35580 BV401_39915
SNZ : DC008_26570 DC008_29540
SFIC : EIZ62_04510 EIZ62_25180
SBY : H7H31_29960 H7H31_30465
STUI : GCM10017668_60930(pepX)
SANT : QR300_04755 QR300_09585
NOY : EXE57_01020 EXE57_08545
NCQ : K6T13_08050 K6T13_12275
SGRG : L0C25_10110 L0C25_10130
AGRA : AGRA3207_000586 AGRA3207_003071
ACIR : OG979_23535 OG979_37355
NOA : BKM31_39665 BKM31_58600
NOW : GBF35_05735 GBF35_37845
NCX : Nocox_05095(pepX1) Nocox_30785(pepX2)
NGN : LCN96_05610 LCN96_42110
SEN : SACE_1771(pepX) SACE_6505
AMD : AMED_2407(pepX) AMED_6004(pepX) AMED_6355(pepX)
AMN : RAM_12245 RAM_30790 RAM_32585
AMM : AMES_2380(pepX) AMES_5919(pepX) AMES_6264(pepX)
AMZ : B737_2381(pepX) B737_5919(pepX) B737_6264(pepX)
AOI : AORI_2204(pepX) AORI_2376(pepX) AORI_5025(pepX)
AJA : AJAP_14380 AJAP_26955 AJAP_28260
AMYC : CU254_09845 CU254_22295
AMYB : BKN51_03600 BKN51_04500 BKN51_17550
AMYY : YIM_13740(pepX1) YIM_36115(pepX2)
AORI : SD37_12010 SD37_12945 SD37_24730
APRT : MUY14_04320 MUY14_05870 MUY14_24430
AROO : NQK81_10455 NQK81_11335 NQK81_41745
SESP : BN6_17310 BN6_22710 BN6_39520
KAL : KALB_5945 KALB_6923 KALB_7965
KPHY : AOZ06_14335 AOZ06_20295 AOZ06_39740 AOZ06_48375
LED : BBK82_01665 BBK82_23770 BBK82_38555
AHM : TL08_08645 TL08_23650
ACTI : UA75_06120 UA75_08680 UA75_27475
ACAD : UA74_06115 UA74_08710 UA74_26885
AHG : AHOG_05850(pepX1) AHOG_08170(pepX2) AHOG_24805(pepX3)
ALO : CRK55786 CRK58607 CRK59792
CROS : N8J89_04440 N8J89_10275 N8J89_19490 N8J89_33235 N8J89_33240
VMA : VAB18032_18850 VAB18032_25230
ACTN : L083_4177 L083_6200
ACTR : Asp14428_02690(pepX_1) Asp14428_70110(pepX_3)
PLAB : C6361_02030 C6361_22140 C6361_22205 C6361_27430
PLAT : C6W10_17100 C6W10_17165 C6W10_19640 C6W10_29625
PFLA : Pflav_041640(pepX_1) Pflav_072760(pepX_2)
PSUU : Psuf_035340 Psuf_082580(pepX)
PRY : Prubr_07320(pepX) Prubr_65340 Prubr_71840
CATI : CS0771_41600(pepX) CS0771_48450
CCAZ : COUCH_12390 COUCH_25340
NAV : JQS30_14035 JQS30_14050 JQS30_14055
BSCA : BBSC_1240 BBSC_1612
BALA : DSM104299_00748(pepX)
SMIZ : 4412673_03782(pepX)
SDJ : NCTC13534_05212(pepX)
PHG : KCTC32516_01392(pepX)
AALG : AREALGSMS7_03937(pepX)
CJG : NCTC13459_00494(pepX)
» show all
Taxonomy
Reference
1
Authors
Zevaco, C., Monnet, V. and Gripon, J.-C.
Title
Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis spp. lactis: purification and properties.
Journal
J Appl Bacteriol 68:357-366 (1990)
Reference
Authors
Meyer-Barton EC, Klein JR, Imam M, Plapp R
Title
Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbruckii ssp. lactis DSM7290.
Journal
Sequence
Reference
Authors
Habibi-Najafi MB, Lee BH.
Title
Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei subsp. casei LLG.
Journal
Reference
Authors
Chich JF, Gripon JC, Ribadeau-Dumas B.
Title
Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents.
Journal
Reference
5
Authors
Chich, J.-F., Chapot-Chartier, M.P., Ribadeau-Dumas, B. and Gripon, J.-C.
Title
Identification of the active site serine of the X-prolyl aminopeptidase from Lactococcus lactis.
Journal
FEBS Lett 314:139-142 (1995)
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.14.11