KEGG   ENZYME: 3.4.14.12
Entry
EC 3.4.14.12                Enzyme                                 
Name
Xaa-Xaa-Pro tripeptidyl-peptidase;
prolyltripeptidyl amino peptidase;
prolyl tripeptidyl peptidase;
prolyltripeptidyl aminopeptidase;
PTP-A;
TPP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
Reaction(IUBMB)
Hydrolysis of Xaa-Xaa-Pro!Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline
Comment
This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which has been implicated in adult periodontal disease [1]. The enzyme releases the N-terminal tripeptide of peptides, such as interleukin-6. It has an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1' position [1]. The size of the peptide does not affect the rate of reaction [1].
History
EC 3.4.14.12 created 2006
Orthology
K18574  Xaa-Xaa-Pro tripeptidyl-peptidase
Genes
PGIPG_1361
PGNPGN_1149
PGTPGTDC60_2108
PENDLA319_05250
PSOECE91St14_21820
PORPJ4862_04730
PMERINE87_02544(ptpA_1)
PJOLK449_16940
SSPII6J01_01345
SBAMSCB77_17455
HCUMUN79_12715
HCFMUN80_11685
FAXFUAX_21740
PPSVPEPS_07150(pepX2)
MOAI6I89_09425
MALSNWE55_15195
FBOJ9309_04540
SHYRLA303_01455
 » show all
Reference
1  [PMID:10092598]
  Authors
Banbula A, Mak P, Bugno M, Silberring J, Dubin A, Nelson D, Travis J, Potempa J
  Title
Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis.
  Journal
J Biol Chem 274:9246-52 (1999)
DOI:10.1074/jbc.274.14.9246
  Sequence
[pgi:PG_1361]
Reference
2  [PMID:12620636]
  Authors
Fujimura S, Ueda O, Shibata Y, Hirai K.
  Title
Isolation and properties of a tripeptidyl peptidase from a periodontal pathogen Prevotella nigrescens.
  Journal
FEMS Microbiol Lett 219:305-9 (2003)
DOI:10.1016/S0378-1097(03)00048-X
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.12
IUBMB Enzyme Nomenclature: 3.4.14.12
ExPASy - ENZYME nomenclature database: 3.4.14.12
BRENDA, the Enzyme Database: 3.4.14.12

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