Entry |
|
Name |
dipeptidyl-peptidase II;
dipeptidyl aminopeptidase II;
dipeptidyl arylamidase II;
carboxytripeptidase;
dipeptidyl peptidase II;
DAP II;
dipeptidyl(amino)peptidase II;
dipeptidylarylamidase
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
|
Reaction(IUBMB) |
Release of an N-terminal dipeptide, Xaa-Yaa!, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
|
Comment |
A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH
|
History |
EC 3.4.14.2 created 1978
|
Orthology |
K01276 | dipeptidyl-peptidase II |
|
Genes |
PANU: | 101009717 116272657 |
MUN: | 110550552 110557034(Dpp7) |
PLOP: | 125345283 125351535(Dpp7) |
UAH: | 113249877 113249879 113249880 113249881 |
SANH: | 107681243(dpp7) 107690688 |
MSAM: | 119892353(dpp7) 119917793 |
ARUT: | 117397025 117964682 |
BBEL: | 109469775 109484650 |
LPIC: | 129277712 129277715 |
APLC: | 110981392 110981393 110981416 110989449 |
PVUL: | 126820270 130010450 |
PDAM: | 113673001 113673003 |
SMIN: | v1.2.018349.t1(symbB.v1.2.018349.t1) v1.2.019631.t1(symbB.v1.2.019631.t1) |
AAF: | AURANDRAFT_2013 AURANDRAFT_28266 |
EHX: | EMIHUDRAFT_204576 EMIHUDRAFT_241178 |
» show all
|
Reference |
|
Authors |
McDonald JK, Leibach FH, Grindeland RE, Ellis S. |
Title |
Purification of dipeptidyl aminopeptidase II (dipeptidyl arylamidase II) of the anterior pituitary gland. Peptidase and dipeptide esterase activities. |
Journal |
J Biol Chem 243:4143-50 (1968) |
Reference |
2 |
Authors |
McDonald, J.K. and Schwabe, C. |
Title |
Intracellular exopeptidases. |
Journal |
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391. |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.4.14.2 |
ExPASy - ENZYME nomenclature database: | 3.4.14.2 |
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