Entry
Name
tripeptidyl-peptidase I;
tripeptidyl aminopeptidase;
tripeptidyl peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
Comment
A lysosomal enzyme that is active at acidic pH. Deficient in classical late-infantile neuronal ceroid lipofuscinosis brain tissue. Belongs in peptidase family S53. Formerly included in EC
3.4.14.8 .
History
EC 3.4.14.9 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992), modified 2000, modified 2001, modified 2003
Orthology
K01279 tripeptidyl-peptidase I
Genes
SANH : 107674083 107697734
CCAR : 109106999 109107532
CAUA : 113060588 113069081 113117469
CGIB : 127933198 127976753
MASI : 127410887 127454948
LCF : 108892480(tpp1) 108892632
MALB : 109953961 109955168(tpp1)
PSPA : 121324114 121330018
ARUT : 117422575 117974029
NTE : NEUTE1DRAFT64480(NEUTE1DRAFT_64480) NEUTE1DRAFT79855(NEUTE1DRAFT_79855)
SMP : SMAC_08129 SMAC_08656
PAN : PODANSg1052 PODANSg587 PODANSg6015
PPSD : QC762_310570 QC762_502840
PPSP : QC763_310570 QC763_502840
PPSA : QC764_310570 QC764_502840
TTT : THITE_159718 THITE_2025173 THITE_2107766 THITE_52349
MTM : MYCTH_2305771 MYCTH_33003 MYCTH_79026
CTHR : CTHT_0000860 CTHT_0020710 CTHT_0032140
MGR : MGG_00940 MGG_03056 MGG_07404 MGG_07559 MGG_09322
PPEI : PpBr36_02320 PpBr36_02465 PpBr36_08199 PpBr36_09464
PGRI : PgNI_01992 PgNI_02466 PgNI_08321 PgNI_10295
TMN : UCRPA7_1709 UCRPA7_3321 UCRPA7_4058 UCRPA7_608 UCRPA7_6236 UCRPA7_7176 UCRPA7_8582
SSCK : SPSK_00106 SPSK_01062 SPSK_07102 SPSK_08579 SPSK_09394 SPSK_09563 SPSK_10746
FGR : FGSG_03072 FGSG_10343 FGSG_12142
FPU : FPSE_01940 FPSE_02153 FPSE_09020
FPOA : FPOAC1_003551 FPOAC1_005429
FVN : FVRRES_00006 FVRRES_03792 FVRRES_05986 FVRRES_10596
FVR : FVEG_03072 FVEG_03494 FVEG_07677 FVEG_09073 FVEG_12895
FOX : FOXG_04542 FOXG_10424 FOXG_13598 FOXG_17187
NHE : NECHADRAFT_40968 NECHADRAFT_56813 NECHADRAFT_81544
FFC : NCS54_00009600 NCS54_00724700 NCS54_00810900
FKR : NCS57_00007200 NCS57_00765000 NCS57_00854100
FMU : J7337_005976 J7337_010307 J7337_013660
TRE : TRIREDRAFT_111838 TRIREDRAFT_123865 TRIREDRAFT_70962 TRIREDRAFT_82623
TRR : M419DRAFT_116864 M419DRAFT_142825 M419DRAFT_26554 M419DRAFT_39131 M419DRAFT_93311
MAW : MAC_00543 MAC_01195 MAC_02025 MAC_02922 MAC_02950 MAC_06811 MAC_08828 MAC_09152
MAJ : MAA_01308 MAA_01699 MAA_03124 MAA_03336 MAA_04783 MAA_05542 MAA_07266 MAA_07727 MAA_08535
PCHM : VFPPC_03197 VFPPC_04178 VFPPC_05277 VFPPC_06350 VFPPC_09216 VFPPC_09462
CMT : CCM_00199 CCM_01649 CCM_01825 CCM_02092 CCM_02560 CCM_02562 CCM_02797 CCM_03029 CCM_03072 CCM_04961 CCM_07318 CCM_07884 CCM_07927 CCM_08311 CCM_08788
AMUS : LMH87_000028 LMH87_000230 LMH87_001345 LMH87_001664 LMH87_002658 LMH87_003157 LMH87_003435 LMH87_003622 LMH87_005654 LMH87_006896 LMH87_007397 LMH87_007745 LMH87_008516 LMH87_008706 LMH87_008726 LMH87_008739 LMH87_008741 LMH87_010046 LMH87_010810
PLJ : VFPFJ_04450 VFPFJ_04489 VFPFJ_05173 VFPFJ_09325 VFPFJ_10185 VFPFJ_10498 VFPFJ_10813 VFPFJ_10845 VFPFJ_11041
PTKZ : JDV02_001295 JDV02_001849 JDV02_002369 JDV02_005788 JDV02_006975 JDV02_007193 JDV02_008785 JDV02_008853
CFJ : CFIO01_02876 CFIO01_03329 CFIO01_13011 CFIO01_13583
CLUP : CLUP02_03794 CLUP02_04485 CLUP02_09045 CLUP02_16169
CHIG : CH63R_02803 CH63R_03327 CH63R_06814 CH63R_07250 CH63R_09678 CH63R_09680
SAPO : SAPIO_CDS1160 SAPIO_CDS5925 SAPIO_CDS6976 SAPIO_CDS9986
ELA : UCREL1_11546 UCREL1_2544 UCREL1_3767 UCREL1_7338
PFY : PFICI_01660 PFICI_01718 PFICI_02958 PFICI_03674 PFICI_05173 PFICI_07289 PFICI_09966 PFICI_12795 PFICI_12915 PFICI_12953 PFICI_13025 PFICI_14077
SSL : SS1G_02857 SS1G_03518 SS1G_04958 SS1G_07268 SS1G_07655 SS1G_09225 SS1G_09268 SS1G_12210 SS1G_13922
BFU : BCIN_03g02040 BCIN_05g05830 BCIN_06g00330 BCIN_06g00620(Bctpp2) BCIN_06g01010 BCIN_06g03070 BCIN_08g01020 BCIN_09g01190 BCIN_10g01890 BCIN_15g03150 BCIN_15g04670(Bcser8)
MBE : MBM_02127 MBM_03157 MBM_05150 MBM_07560 MBM_08269 MBM_08512 MBM_08634 MBM_09864
PSCO : LY89DRAFT_108206 LY89DRAFT_360238 LY89DRAFT_565423 LY89DRAFT_588285 LY89DRAFT_618634 LY89DRAFT_619683 LY89DRAFT_630884 LY89DRAFT_633625 LY89DRAFT_641751 LY89DRAFT_650703 LY89DRAFT_654181 LY89DRAFT_657455 LY89DRAFT_683782 LY89DRAFT_688270 LY89DRAFT_691374 LY89DRAFT_692286 LY89DRAFT_697458 LY89DRAFT_698854 LY89DRAFT_698947 LY89DRAFT_712030 LY89DRAFT_716277 LY89DRAFT_716980 LY89DRAFT_741189 LY89DRAFT_750974
GLZ : GLAREA_00572 GLAREA_02460 GLAREA_03934 GLAREA_05269 GLAREA_08177 GLAREA_08649 GLAREA_09716 GLAREA_10680 GLAREA_11487
ANI : ANIA_03020 ANIA_07159 ANIA_07201
AFM : AFUA_3G08930 AFUA_4G03490 AFUA_4G14000 AFUA_6G10250
ACT : ACLA_004520 ACLA_036900 ACLA_052980 ACLA_055020
NFI : NFIA_029950 NFIA_055970 NFIA_068200 NFIA_102320
AOR : AO090005001380 AO090011000235 AO090023000263 AO090026000083 AO090166000084
ANG : An01g01750 An03g01010 An06g00190 An08g04640 An11g01110 An14g02470 An16g02250
AFV : AFLA_004200 AFLA_006223 AFLA_006623 AFLA_007599 AFLA_011411
ALUC : AKAW2_10068A AKAW2_20367A AKAW2_30582S(SED4_1) AKAW2_40930A(SED2) AKAW2_52022A(SED4_2) AKAW2_70190A(SED4_3) AKAW2_80106S(SED1)
ACHE : ACHE_40399A(SED4) ACHE_60568S(SED2) ACHE_80798S(SED1)
APUU : APUU_20891A(SED1) APUU_30508S(SED4) APUU_80775A(SED2)
PCS : N7525_001143 N7525_004446 N7525_008833 N7525_009924
PDP : PDIP_08500 PDIP_12220 PDIP_47100 PDIP_77090
POU : POX_e07310 POX_f07768 POX_g08659 POX_g08775 POX_g09283
TMF : EYB26_001983 EYB26_003974 EYB26_004983 EYB26_006587 EYB26_007595 EYB26_009287 EYB26_009520 EYB26_009746
TRG : TRUGW13939_00959 TRUGW13939_00974 TRUGW13939_01453 TRUGW13939_01552 TRUGW13939_01603 TRUGW13939_02153 TRUGW13939_03945 TRUGW13939_05184 TRUGW13939_05337 TRUGW13939_05381 TRUGW13939_05845 TRUGW13939_07404 TRUGW13939_10140 TRUGW13939_10923
CIM : CIMG_00167 CIMG_02188 CIMG_03887
CPW : CPC735_004570 CPC735_038590 CPC735_059790
URE : UREG_00260 UREG_01816 UREG_02074
PBL : PAAG_00676 PAAG_00680 PAAG_03787
PBN : PADG_03290 PADG_04152 PADG_04156
ABE : ARB_04101 ARB_04678 ARB_05765
TVE : TRV_03120 TRV_03885 TRV_04476
AJE : HCAG_04281 HCAG_04284 HCAG_04348
BGH : BDBG_00742 BDBG_01898 BDBG_01902 BDBG_01978
PNO : SNOG_01085(SNOG_01084) SNOG_09464 SNOG_10163 SNOG_12941 SNOG_14758
PTE : PTT_08432 PTT_12932 PTT_15673 PTT_17627 PTT_18090 PTT_20078
BZE : COCCADRAFT_35948 COCCADRAFT_85950 COCCADRAFT_9217 COCCADRAFT_95293
BSC : COCSADRAFT_150286 COCSADRAFT_169238 COCSADRAFT_86411
BOR : COCMIDRAFT_103191 COCMIDRAFT_107145 COCMIDRAFT_84631
AALT : CC77DRAFT_930263 CC77DRAFT_948401 CC77DRAFT_948433
ARAB : EKO05_0003405 EKO05_0004010 EKO05_0005545 EKO05_0007440 EKO05_0009070 EKO05_0010569
ZTR : MYCGRDRAFT_37389 MYCGRDRAFT_38337 MYCGRDRAFT_38910 MYCGRDRAFT_50687 MYCGRDRAFT_67015 MYCGRDRAFT_67381 MYCGRDRAFT_72506 MYCGRDRAFT_75846 MYCGRDRAFT_83794 MYCGRDRAFT_84465
PFJ : MYCFIDRAFT_115832 MYCFIDRAFT_161112 MYCFIDRAFT_200693 MYCFIDRAFT_206911 MYCFIDRAFT_208562 MYCFIDRAFT_33445 MYCFIDRAFT_52295 MYCFIDRAFT_57642 MYCFIDRAFT_58745 MYCFIDRAFT_60025 MYCFIDRAFT_61094
FFU : CLAFUR5_00172 CLAFUR5_02368 CLAFUR5_03393 CLAFUR5_03865 CLAFUR5_03866 CLAFUR5_05446 CLAFUR5_08241 CLAFUR5_09261 CLAFUR5_11952 CLAFUR5_14108
CBET : CB0940_02172 CB0940_03056 CB0940_04096 CB0940_04259 CB0940_05640 CB0940_05921 CB0940_07641
BCOM : BAUCODRAFT_104269 BAUCODRAFT_111098 BAUCODRAFT_113640 BAUCODRAFT_119783 BAUCODRAFT_152438 BAUCODRAFT_22902 BAUCODRAFT_306249
NPA : UCRNP2_157 UCRNP2_3892 UCRNP2_429 UCRNP2_5270 UCRNP2_8356 UCRNP2_9444
PPL : POSPLDRAFT_100262 POSPLDRAFT_100933 POSPLDRAFT_39235 POSPLDRAFT_56190 POSPLDRAFT_88376 POSPLDRAFT_89125 POSPLDRAFT_89244 POSPLDRAFT_89318 POSPLDRAFT_89706 POSPLDRAFT_98229 POSPLDRAFT_98402 POSPLDRAFT_99394
TVS : TRAVEDRAFT_113847 TRAVEDRAFT_114132 TRAVEDRAFT_119513 TRAVEDRAFT_126771 TRAVEDRAFT_129640 TRAVEDRAFT_129702 TRAVEDRAFT_129797 TRAVEDRAFT_130509 TRAVEDRAFT_135882 TRAVEDRAFT_141203 TRAVEDRAFT_147958 TRAVEDRAFT_152610 TRAVEDRAFT_153507 TRAVEDRAFT_166188 TRAVEDRAFT_169734 TRAVEDRAFT_174508 TRAVEDRAFT_22306 TRAVEDRAFT_31004 TRAVEDRAFT_43466 TRAVEDRAFT_50426 TRAVEDRAFT_50427 TRAVEDRAFT_50436 TRAVEDRAFT_50437 TRAVEDRAFT_50694 TRAVEDRAFT_53633 TRAVEDRAFT_62904 TRAVEDRAFT_69742
DSQ : DICSQDRAFT_100435 DICSQDRAFT_100668 DICSQDRAFT_101252 DICSQDRAFT_104579 DICSQDRAFT_129327 DICSQDRAFT_139862 DICSQDRAFT_149462 DICSQDRAFT_150533 DICSQDRAFT_157239 DICSQDRAFT_163273 DICSQDRAFT_167044 DICSQDRAFT_172489 DICSQDRAFT_173623 DICSQDRAFT_178456 DICSQDRAFT_182861 DICSQDRAFT_182908 DICSQDRAFT_183045 DICSQDRAFT_183769 DICSQDRAFT_52085 DICSQDRAFT_59098 DICSQDRAFT_64587 DICSQDRAFT_68823 DICSQDRAFT_91417 DICSQDRAFT_93881 DICSQDRAFT_99652
PCO : PHACADRAFT_117789 PHACADRAFT_145272 PHACADRAFT_151536 PHACADRAFT_205997 PHACADRAFT_207476 PHACADRAFT_207479 PHACADRAFT_207484 PHACADRAFT_250501 PHACADRAFT_253175 PHACADRAFT_257222 PHACADRAFT_257728 PHACADRAFT_262763 PHACADRAFT_263851 PHACADRAFT_266366 PHACADRAFT_89753
SHS : STEHIDRAFT_119869 STEHIDRAFT_124448 STEHIDRAFT_131451 STEHIDRAFT_131846 STEHIDRAFT_146058 STEHIDRAFT_149190 STEHIDRAFT_149915 STEHIDRAFT_160819 STEHIDRAFT_168469 STEHIDRAFT_172688 STEHIDRAFT_51847 STEHIDRAFT_54661 STEHIDRAFT_58060 STEHIDRAFT_62440 STEHIDRAFT_65259 STEHIDRAFT_65276 STEHIDRAFT_67891 STEHIDRAFT_94707
HIR : HETIRDRAFT_107829 HETIRDRAFT_115474 HETIRDRAFT_120104 HETIRDRAFT_122670 HETIRDRAFT_127284 HETIRDRAFT_146274 HETIRDRAFT_150764 HETIRDRAFT_156003 HETIRDRAFT_325904 HETIRDRAFT_440247 HETIRDRAFT_44412 HETIRDRAFT_44515 HETIRDRAFT_62310 HETIRDRAFT_62330 HETIRDRAFT_64560 HETIRDRAFT_67557
PSQ : PUNSTDRAFT_106327 PUNSTDRAFT_125074 PUNSTDRAFT_136316 PUNSTDRAFT_143004 PUNSTDRAFT_144529 PUNSTDRAFT_43872 PUNSTDRAFT_53907 PUNSTDRAFT_68527 PUNSTDRAFT_83848 PUNSTDRAFT_95165 PUNSTDRAFT_96921
ADL : AURDEDRAFT_103663 AURDEDRAFT_104391 AURDEDRAFT_106617 AURDEDRAFT_111692 AURDEDRAFT_111879 AURDEDRAFT_114109 AURDEDRAFT_115325 AURDEDRAFT_116999 AURDEDRAFT_117156 AURDEDRAFT_144079 AURDEDRAFT_149915 AURDEDRAFT_160935 AURDEDRAFT_182664 AURDEDRAFT_184754 AURDEDRAFT_52038 AURDEDRAFT_57027 AURDEDRAFT_57221 AURDEDRAFT_58873 AURDEDRAFT_64291 AURDEDRAFT_64960 AURDEDRAFT_84563
FME : FOMMEDRAFT_112220 FOMMEDRAFT_126575 FOMMEDRAFT_137010 FOMMEDRAFT_159445 FOMMEDRAFT_159765 FOMMEDRAFT_24970 FOMMEDRAFT_78954
GTR : GLOTRDRAFT_117484 GLOTRDRAFT_125493 GLOTRDRAFT_139347 GLOTRDRAFT_36326 GLOTRDRAFT_39789 GLOTRDRAFT_48069 GLOTRDRAFT_48672 GLOTRDRAFT_48851 GLOTRDRAFT_50155 GLOTRDRAFT_54176
RSX : RhiXN_04546 RhiXN_07901
LBC : LACBIDRAFT_185466 LACBIDRAFT_191088 LACBIDRAFT_248220 LACBIDRAFT_301946 LACBIDRAFT_381800
CCI : CC1G_01435 CC1G_05911
ABP : AGABI1DRAFT72616(AGABI1DRAFT_72616) AGABI1DRAFT83390(AGABI1DRAFT_83390)
ABV : AGABI2DRAFT193429(AGABI2DRAFT_193429) AGABI2DRAFT195772(AGABI2DRAFT_195772)
PCUB : JR316_0004589 JR316_0005044 JR316_0006990 JR316_0006991 JR316_0008299 JR316_0012090 JR316_0013375
MPR : MPER_00656 MPER_02627 MPER_10525
MRR : Moror_10461 Moror_10738 Moror_13848 Moror_16988 Moror_1753 Moror_7100
MORE : E1B28_000070 E1B28_008368 E1B28_008374
SCM : SCHCO_02499350(SCHCODRAFT_02499350) SCHCO_02618632(SCHCODRAFT_02618632) SCHCO_02622814(SCHCODRAFT_02622814) SCHCO_02627176(SCHCODRAFT_02627176) SCHCO_02627185(SCHCODRAFT_02627185)
CPUT : CONPUDRAFT_105544 CONPUDRAFT_113847 CONPUDRAFT_123071 CONPUDRAFT_131111 CONPUDRAFT_131138 CONPUDRAFT_131341 CONPUDRAFT_139844 CONPUDRAFT_146770 CONPUDRAFT_158303 CONPUDRAFT_158494 CONPUDRAFT_57073 CONPUDRAFT_64217 CONPUDRAFT_64393 CONPUDRAFT_68107 CONPUDRAFT_68118 CONPUDRAFT_73606 CONPUDRAFT_84967 CONPUDRAFT_86079 CONPUDRAFT_87230
SLA : SERLADRAFT_360671 SERLADRAFT_414416 SERLADRAFT_414423 SERLADRAFT_414426 SERLADRAFT_436156 SERLADRAFT_436157 SERLADRAFT_436158 SERLADRAFT_446956 SERLADRAFT_463329
PGR : PGTG_15038 PGTG_16628 PGTG_16629 PGTG_17496
PTRC : PtA15_2A42 PtA15_2A43 PtA15_2A80 PtA15_2A83 PtA15_9A706
PSTR : Pst134EA_004642 Pst134EA_004647 Pst134EA_004696 Pst134EA_004703 Pst134EA_026726 Pst134EA_026732 Pst134EA_027835
MLR : MELLADRAFT_45226 MELLADRAFT_46732 MELLADRAFT_86030
MBR : MONBRDRAFT_28049 MONBRDRAFT_37973
SRE : PTSG_01230 PTSG_08634
DFA : DFA_09883 DFA_10992(tpp1)
ACAN : ACA1_020120 ACA1_077970 ACA1_087870 ACA1_098270 ACA1_101480 ACA1_109090 ACA1_153950 ACA1_154200 ACA1_157540 ACA1_200110 ACA1_321740
SMIN : v1.2.016800.t1(symbB.v1.2.016800.t1) v1.2.026734.t1(symbB.v1.2.026734.t1)
FCY : FRACYDRAFT_238110 FRACYDRAFT_245057
AAF : AURANDRAFT_24350 AURANDRAFT_71024 AURANDRAFT_71465
PIF : PITG_03813 PITG_13421
PSOJ : PHYSODRAFT_459946 PHYSODRAFT_474748
SPAR : SPRG_03074 SPRG_03727 SPRG_05100 SPRG_07208 SPRG_11745 SPRG_15916 SPRG_18757
EHX : EMIHUDRAFT_360083 EMIHUDRAFT_441704
NGR : NAEGRDRAFT_57131 NAEGRDRAFT_58872(AM24) NAEGRDRAFT_72167 NAEGRDRAFT_78259
» show all
Taxonomy
Reference
Authors
Ezaki J, Tanida I, Kanehagi N, Kominami E.
Title
A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.
Journal
Reference
Authors
Rawlings ND, Barrett AJ.
Title
Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis.
Journal
Reference
Authors
Ezaki J, Takeda-Ezaki M, Oda K, Kominami E
Title
Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis.
Journal
Sequence
Reference
Authors
Junaid MA, Wu G, Pullarkat RK
Title
Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis.
Journal
Sequence
Reference
Authors
Lin L, Sohar I, Lackland H, Lobel P.
Title
The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.9
ExPASy - ENZYME nomenclature database: 3.4.14.9