KEGG ENZYME: 3.4.17.2

ENZYME: 3.4.17.2

Entry

EC 3.4.17.2                 Enzyme

Name

carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Preferential release of a C-terminal lysine or arginine amino acid

Comment

A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).

History

EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2

Orthology

K01291

carboxypeptidase B

Genes

HSA:	1360(CPB1)

PTR:	460763(CPB1)

PPS:	100992024(CPB1)

GGO:	101129511(CPB1)

PON:	100434248(CPB1)

NLE:	100606718(CPB1)

HMH:	116481117(CPB1)

MCC:	712639(CPB1)

MCF:	102133877(CPB1)

MTHB:

126947489

MNI:	105470042(CPB1)

CSAB:

103241512(CPB1)

CATY:

105587503(CPB1)

PANU:

101002891(CPB1)

TGE:	112619758(CPB1)

MLEU:

105534118(CPB1)

RRO:	104671554(CPB1)

RBB:	108518296(CPB1)

TFN:	117084056(CPB1)

PTEH:

111544724(CPB1)

CANG:

105523880(CPB1)

CJC:	100406051(CPB1)

SBQ:	101037025(CPB1)

CIMI:

108300863(CPB1)

CSYR:

103275577(CPB1)

MMUR:

105881239(CPB1)

LCAT:

123630152(CPB1)

PCOQ:

105809142(CPB1)

OGA:	100955228(CPB1)

MMU:	76703(Cpb1)

MCAL:

110291636(Cpb1)

MPAH:

110320577(Cpb1)

RNO:	24271(Cpb1)

MCOC:

116094749(Cpb1)

ANU:	117707479(Cpb1)

MUN:	110563021(Cpb1)

CGE:	100751091(Cpb1)

MAUA:

101834834(Cpb1)

PROB:

127223381(Cpb1)

PLEU:

114686243(Cpb1)

MORG:

121452995(Cpb1)

MFOT:

126490664

AAMP:

119826800(Cpb1)

NGI:	103745993(Cpb1)

HGL:	101715608(Cpb1)

CPOC:

100716012(Cpb1)

CCAN:

109682822(Cpb1)

DORD:

105996002(Cpb1)

DSP:	122095228(Cpb1)

PLOP:

125342453(Cpb1)

NCAR:

124993158

MMMA:

107143326(Cpb1)

OCU:

100358803

OPI:	101533613(CPB1)

TUP:	102469136(CPB1)

GVR:

103597450

CFA:	403512(CPB1)

CLUD:

112661126(CPB1)

VVP:	112932756(CPB1)

VLG:	121479046(CPB1)

NPO:	129507211(CPB1)

AML:	100471468(CPB1)

UMR:	103678088(CPB1)

UAH:	113254039(CPB1)

UAR:	123802734(CPB1)

ELK:

111147955

LLV:

125098503

MPUF:

101692613(CPB1)

MNP:	132010155(CPB1)

MLK:	131825903(CPB1)

NVS:	122910443(CPB1)

ORO:	101376449(CPB1)

EJU:	114209076(CPB1)

ZCA:	113916955(CPB1)

MLX:	117999403(CPB1)

NSU:	110576787(CPB1)

LWW:	102733422(CPB1)

FCA:	101082684(CPB1)

PYU:	121033804(CPB1)

PCOO:

112849673(CPB1)

PBG:	122491878(CPB1)

PVIV:

125175745(CPB1)

LRUF:

124527000

PTG:	102968194(CPB1)

PPAD:

109260704(CPB1)

PUC:

125921959

AJU:

106975221

HHV:	120237633(CPB1)

BTA:	510039(CPB1)

BOM:	102265167(CPB1)

BIU:	109564536(CPB1)

BBUB:

102406620(CPB1)

BBIS:

105001754(CPB1)

CHX:	102184477(CPB1)

OAS:	101123433(CPB1)

BTAX:

128053929(CPB1)

ODA:	120858396(CPB1)

CCAD:

122445076(CPB1)

MBEZ:

129551204(CPB1)

SSC:	397341(CPB1)

CFR:	102508460(CPB1)

CBAI:

105081274(CPB1)

CDK:	105089516(CPB1)

VPC:	102531278(CPB1)

BACU:

103002331(CPB1)

BMUS:

118894504(CPB1)

LVE:	103090379(CPB1)

OOR:	101269328(CPB1)

DLE:	111179171(CPB1)

PCAD:

102974801(CPB1)

PSIU:

116753196(CPB1)

NASI:

112415903(CPB1)

ECB:	100058959(CPB1)

EPZ:	103558753(CPB1)

EAI:	106829437(CPB1)

MYB:	102244805(CPB1)

MYD:	102772230(CPB1)

MMYO:

118677112(CPB1)

MLF:	102419077(CPB1)

PKL:	118722863(CPB1)

EFUS:

103302019(CPB1)

MNA:	107544050(CPB1)

DRO:	112300986(CPB1)

SHON:

118997900(CPB1)

AJM:	119055977(CPB1)

PDIC:

114490912(CPB1)

PHAS:

123827086(CPB1)

MMF:	118617487(CPB1)

PPAM:

129080002(CPB1)

HAI:	109375861(CPB1)

RFQ:	117037814(CPB1)

PALE:

102895857(CPB1)

PGIG:

120593794(CPB1)

PVP:	105294947(CPB1)

RAY:	107513417(CPB1)

MJV:	108388604(CPB1)

TOD:	119256908(CPB1)

SARA:

101537528(CPB1)

LAV:	100658791(CPB1)

TMU:

101345894

ETF:	101647120(CPB1)

DNM:	101439280(CPB1)

MDO:	100012656(CPB1)

GAS:	123241970(CPB1)

SHR:	100927003(CPB1)

AFZ:

127552966

PCW:	110204795(CPB1)

OAA:	100091762(CPB1)

GGA:	424888(CPB1)

PCOC:

116230871(CPB1)

MGP:	100544821(CPB1)

CJO:	107318162(CPB1)

TPAI:

128082573(CPB1)

LMUT:

125697882(CPB1)

NMEL:

110398295(CPB1)

APLA:

101797837(CPB1)

ACYG:

106036191

CATA:

118247025(CPB1)

AFUL:

116492661(CPB1)

TGU:	100222062(CPB1)

LSR:	110473919(CPB1)

SCAN:

103815405(CPB1)

PMOA:

120508574(CPB1)

OTC:	121341125(CPB1)

PRUF:

121357960(CPB1)

GFR:	102034134(CPB1)

FAB:	101812580(CPB1)

OMA:	130256967(CPB1)

PHI:

102112631

PMAJ:

107209058(CPB1)

CCAE:

111933485(CPB1)

CCW:	104693471(CPB1)

CBRC:

103624820(CPB1)

ETL:

114057377

ZAB:	102069952(CPB1)

ACHL:

103803235

SVG:

106862580

MMEA:

130580395(CPB1)

HRT:	120757127(CPB1)

FPG:	101914576(CPB1)

FCH:	102052617(CPB1)

CLV:	102083429(CPB1)

EGZ:	104127123(CPB1)

NNI:	104015688(CPB1)

PCRI:

104026830

PLET:

104613878

EHS:	104514127(CPB1)

ACUN:

113483340(CPB1)

TALA:

104359305(CPB1)

PADL:

103913837

AFOR:

103901440

ACHC:

115346850(CPB1)

HLE:	104832261(CPB1)

AGEN:

126039406

GCL:

127020207

CCRI:

104161255(CPB1)

CSTI:

104550543

CMAC:

104476157(CPB1)

MUI:	104533360(CPB1)

BREG:

104639578

FGA:	104082615(CPB1)

GSTE:

104255369

LDI:	104352696(CPB1)

MNB:

103780797

OHA:	104338758(CPB1)

NNT:

104399301

SHAB:

115611596(CPB1)

DPUB:

104309518(CPB1)

PGUU:

104461861(CPB1)

ACAR:

104528415(CPB1)

CPEA:

104392327(CPB1)

AVIT:

104267024

CVF:	104284991(CPB1)

RTD:	128911212(CPB1)

CUCA:

104063419(CPB1)

TEO:

104369950

BRHI:

104501769

AAM:	106485858(CPB1)

AROW:

112962156(CPB1)

NPD:	112947448(CPB1)

TGT:	104576161(CPB1)

DNE:	112981681(CPB1)

SCAM:

104153215(CPB1)

ASN:

102371682

AMJ:	102570215(CPB1)

CPOO:

109308307(CPB1)

GGN:	109288135(CPB1)

PSS:

102455777

CMY:

102929825

CCAY:

125642091

DCC:

119861919

CPIC:

101953934

TST:

117882840

CABI:

116839938

MRV:

120371996

ACS:	100562609(cpb1)

ASAO:

132770614

PVT:

110073048

SUND:

121927004(CPB1)

PBI:

103064521

PMUR:

107284837(CPB1)

CTIG:

120313105 120314649

TSR:

106538569

PGUT:

117678308

APRI:

131200671

PTEX:

113436882

NSS:

113410288

VKO:	123024761(CPB1)

PMUA:

114597863

PRAF:

128414641

ZVI:

118093640

HCG:

128351233

GJA:	107124660(CPB1)

STOW:

125437975

EMC:

129332120

XLA:	108716366 495368(cpb1.S) 733324

XTR:	496994(cpb1)

NPR:	108797312 108797314

RTEM:

120936609 120936610 120936612

BBUF:

121000001 121000002(CPB1)

BGAR:

122934978 122935842

MUO:	115478674(CPB1)

GSH:	117366353(CPB1)

DRE:	322412(cpb1)

SRX:	107739144(cpb1)

SANH:

107687549

SGH:	107588040(cpb1)

CCAR:

109051049(cpb1) 109051051

CAUA:

113042243 113065920

CGIB:

127946118 128013036

PTET:

122330098(cpb1)

LROH:

127155602(cpb1)

OMC:	131533538(cpb1)

PPRM:

120475800(cpb1)

RKG:	130084461(cpb1)

MAMB:

125258029(cpb1)

CIDE:

127505714

MASI:

127431856 127434253

TROS:

130547376(agtr1b)

TDW:	130413257(cpb1)

MANU:

129426229(cpb1)

IPU:

108272506

IFU:	128614947(cpb1)

PHYP:

113545433

SMEO:

124383839(cpb1)

TFD:	113651177(cpb1)

TVC:	132845537(cpb1)

AMEX:

103027518(cpb1)

CMAO:

118815849(cpb1)

EEE:

113584770

CHAR:

105889252 105889322 105889323

TRU:

101065526

TFS:	130514082(cpb1)

TNG:	GSTEN00023935G001

LCO:	104937211(cpb1)

NCC:

104965401

TBEN:

117497523(cpb1)

CGOB:

115025725(cpb1)

PGEO:

117465833(cpb1)

GACU:

117549902(cpb1)

EMAC:

134858002(cpb1)

ELY:	117264410(cpb1)

EFO:	125881667(cpb1)

PLEP:

121960595(cpb1) 121963515

SLUC:

116053755(cpb1)

ECRA:

117937952(cpb1)

ESP:	116672341(cpb1)

PFLV:

114549602(cpb1)

GAT:	120811322(cpb1)

PPUG:

119198921(cpb1)

AFB:	129110442(cpb1)

CLUM:

117749608(cpb1)

PSWI:

130205910(cpb1)

MSAM:

119910408(cpb1)

SCHU:

122866662(cpb1)

CUD:	121527280(cpb1)

ALAT:

119008623(cpb1)

MZE:	101480644(cpb1)

ONL:	100702694(cpb1)

OAU:	116314465(cpb1)

OLA:	101169819(cpb1)

OML:	112151102(cpb1)

CSAI:

133422907(cpb1)

XMA:	102232269(cpb1)

XCO:	114136502(cpb1)

XHE:	116711775(cpb1)

PRET:

103456548(cpb1)

PFOR:

103140421

PLAI:

106950253

PMEI:

106931585

GAF:	122824569(cpb1)

PPRL:

129364940(cpb1)

CVG:	107096477(cpb1)

CTUL:

119788913(cpb1)

GMU:	124857753(cpb1)

NFU:	107382805(cpb1)

KMR:	108230520(cpb1)

ALIM:

106513362(cpb1)

NWH:	119426552(cpb1)

AOCE:

111579237(cpb1)

MCEP:

124995724(cpb1)

CSEM:

103377267(cpb1)

POV:	109629670(cpb1)

SSEN:

122785014(cpb1)

HHIP:

117753689(cpb1)

HSP:	118098741(cpb1)

SMAU:

118291297(cpb1)

LCF:

108881689

SDU:	111237915(cpb1)

SLAL:

111656271 111664977

XGL:	120789829(cpb1)

HCQ:

109519484

SSCV:

125985920

SBIA:

133492994(cpb1)

PEE:	133396346(cpb1)

PTAO:

133470542(cpb1)

BPEC:

110170041(cpb1)

MALB:

109961496(cpb1)

BSPL:

114854746(cpb1)

SJO:	128382619(cpb1)

SASA:

100196225(cbpb1)

OTW:	112227610(cpb1)

OMY:	110490876(cpb1)

OGO:	124039440(cpb1)

OKI:

109883246

OKE:	118380037(cpb1)

SALP:

112074819

SNH:	120038059(cpb1)

CCLU:

121556330(cpb1)

ELS:

105026596

SFM:

108927668

PKI:

111840702

AANG:

118226628(cpb1)

LOC:	102696207(cpb1)

PSPA:

121322869 121326681(cpb1)

ARUT:

117423574(cpb1) 117423575

PSEX:

120533734(cpb1)

LCM:	102347915(CPB1)

CMK:

103184479

RTP:	109915629 109915630 109915631(cpb1)

CPLA:

122556172(cpb1) 122556361

HOC:	132821423 132821771

LERI:

129703333 129703334 129703790

PMRN:

116956800 116956807

CIN:	100179788 100181959

SCLV:

120345672 120346029 120346135 120346136

LPIC:

129265974 129280865 129281537 129281547

DER:

6544308

DPO:

4813564

DPE:

6597184

DMN:

108165536

DWI:

6639599

DMO:	Dmoj_GI12855 Dmoj_GI12859 Dmoj_GI20107 Dmoj_GI20119

DAZ:	108611601 108614325 108614328

DNV:	108650121 108652278

MDE:

101895246

LCQ:

111684849

ACOZ:

120949967

AMER:

121592755

CQU:	CpipJ_CPIJ010806

AME:

551327

ALAB:

122710957

ADR:

102675322

AFLR:

100867865

BIM:

100746741

BTER:

100649475

BPYO:

122575243

CCAL:

108626036

OBB:

114871244

MGEN:

117226134

MDL:

103569002

DSM:

124405396

NFB:

124175635

HAW:	110373533 110373545

TNL:

113499978

BTAB:

109035442

BROR:

134542725

DMK:	116935390 123466444 123472379

PTRU:

123516176

ESN:

126985762

HAZT:

108669645 108672726 108673501

PPOI:

119102555 119102857

DFR:	124492514 124499926

PVUL:

126815856

GAE:

121389552

HRF:

124116362

HRJ:	124274751 124286202

CRG:	105322408 105345633 117683583

CANU:

128164092

OED:	125653503 125654799 125664371

PMAX:

117338266

DPOL:

127855630

OSN:

115226688

NVE:

5519024

ATEN:

116299718 116307328 116307329

HSY:

130658470

» show all

Reference

Authors

Folk, J.E.

Title

Carboxypeptidase B (porcine pancreas).

Journal

Methods Enzymol 19:504-508 (1970)

Reference

2 [PMID:1009123]

Authors

Brodrick JW, Geokas MC, Largman C.

Title

Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.

Journal

Biochim Biophys Acta 452:468-81 (1976)
DOI:10.1016/0005-2744(76)90197-2

Reference

3 [PMID:40714]

Authors

Butterworth J, Duncan JJ.

Title

Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.

Journal

Clin Chim Acta 97:39-43 (1979)
DOI:10.1016/0009-8981(79)90023-8

Reference

4 [PMID:6130442]

Authors

Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.

Title

Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?

Journal

Life Sci 31:1793-6 (1982)
DOI:10.1016/0024-3205(82)90212-0

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.2

IUBMB Enzyme Nomenclature:

3.4.17.2

ExPASy - ENZYME nomenclature database:

3.4.17.2

BRENDA, the Enzyme Database:

3.4.17.2

CAS:

9025-24-5

DBGET integrated database retrieval system