Entry |
|
Name |
lysine carboxypeptidase;
carboxypeptidase N;
arginine carboxypeptidase;
kininase I;
anaphylatoxin inactivator;
plasma carboxypeptidase B;
creatine kinase conversion factor;
bradykinase;
kininase Ia;
hippuryllysine hydrolase;
bradykinin-decomposing enzyme;
protaminase;
CPase N;
creatinine kinase convertase;
peptidyl-L-lysine(-L-arginine) hydrolase;
CPN
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
|
Reaction(IUBMB) |
Release of a C-terminal basic amino acid, preferentially lysine
|
Comment |
A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).
|
History |
EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989
|
Orthology |
K01292 | carboxypeptidase N catalytic subunit |
|
Genes |
XLA: | 108696975(cpn1.L) 398791(cpn1.S) |
SANH: | 107684044 107702463 |
SGH: | 107566747 107581572(cpn1) |
CCAR: | 109094710 109100080(cpn1) |
CAUA: | 113069504 113073777 113111602 |
CGIB: | 127969430 128025382 |
MASI: | 127423381 127426890 |
PSPA: | 121322021 121325968 |
ARUT: | 117415124 117417952 |
BBEL: | 109466903 109478523 109484003 |
» show all
|
Reference |
|
Authors |
Plummer TH Jr, Erdos EG. |
Title |
Human plasma carboxypeptidase N. |
Journal |
|
Reference |
|
Authors |
Levin Y, Skidgel RA, Erdos EG. |
Title |
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i). |
Journal |
|
Reference |
|
Authors |
Skidgel RA. |
Title |
Basic carboxypeptidases: regulators of peptide hormone activity. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 3.4.17.3 |
ExPASy - ENZYME nomenclature database: | 3.4.17.3 |
|