Entry
Name
acylaminoacyl-peptidase;
acylamino-acid-releasing enzyme;
N-acylpeptide hydrolase;
N-formylmethionine (fMet) aminopeptidase;
alpha-N-acylpeptide hydrolase;
oxidized protein hydrolase;
acylpeptide hydrolase;
AARE;
AAP;
OPH;
AAH;
APEH;
ACPH
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
(1) cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide;
(2) internal cleavage of oxidized and glycated proteins
Comment
This is a bifunctional serine protease that has exopeptidase activity against Nalpha-acylated peptides and endopeptidase activity against oxidized and glycated proteins. In its exopeptidase mode the enzyme cleaves an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This class of enzymes is evolutionary deeply conserved and is found in bacteria, archaea, animals and plants with different quartenary structures. In humans, malfunction is linked to different types of cancer and sarcoma cell viability. In peptidase family S9 (prolyl oligopeptidase family).
History
EC 3.4.19.1 created 1978 as EC 3.4.14.3, transferred 1981 to EC 3.4.19.1, modified 2023
Orthology
K01303 acylaminoacyl-peptidase
Genes
GGA : 415926(APEH) 770794(AAREL)
PCOC : 116241103 116241105
CJO : 107319598 107319599(APEH)
TPAI : 128078761 128078763
LMUT : 125698807 125698808
NMEL : 110405049(APEH) 110405050
APLA : 113845017 113845085
ACYG : 106048758 106048772
CATA : 118253669 118253670
AFUL : 116492926 116493144(APEH)
PMOA : 120495691(APEH) 120514120
PRUF : 121352763 121352923
GFR : 102042072(APEH) 102042238
FAB : 101810254 101815864(APEH)
CBRC : 103614353(APEH) 103614354
MMEA : 130574684 130574686
FPG : 101919631(APEH) 101919804
FCH : 102059371(APEH) 102059543
TALA : 116959110 116959532
ACHC : 115353782 115353783(APEH)
HLE : 104828136(APEH) 104828137
AGEN : 126049748 126049749
LDI : 104348928(APEH) 104351682
SHAB : 115614320 115614688
DPUB : 104306650 104306674
RTD : 128915721 128915839 128915864
AROW : 112960594 112960600
SCAM : 104147870(APEH) 104147872
ACS : 100567769(apeh) 103277916
ASAO : 132769123(APEH) 132769124
SUND : 121920358 121921307(APEH)
PBI : 103058104(APEH) 103063154
PMUR : 107288723 107288725
CTIG : 120315024 120315025(APEH)
PGUT : 117679059 117679069
APRI : 131190169 131190170
PTEX : 113454172 113454183
PMUA : 114591526(APEH) 114591527
PRAF : 128408143 128408144(APEH)
ZVI : 118080574 118080575(APEH)
GJA : 107109058(APEH) 107109059
STOW : 125429078 125430022
EMC : 129327419 129329075(APEH)
DRE : 100333019(apeh) 678599(zgc:136971)
SANH : 107669673 107698444(apeh)
CCAR : 109083451(apeh) 109095384 109110148
CAUA : 113078400 113107799(apeh) 113107954
CGIB : 127963345(zgc:136971) 128019178
PTET : 122335451(apeh) 122350376(zgc:136971)
LROH : 127170023(apeh) 127170281(zgc:136971)
OMC : 131545387(zgc:136971) 131545606(apeh)
PPRM : 120481299 120483563(zgc:136971)
RKG : 130075709 130094540(zgc:136971)
MAMB : 125279882(zgc:136971) 125280535(apeh)
CIDE : 127517488 127517721
MASI : 127415069(zgc:136971) 127424693 127424731
TROS : 130549594(apeh) 130567838(zgc:136971)
TDW : 130439934(zgc:136971) 130440426(apeh)
MANU : 129413407 129414948
IPU : 108265705 108265926(zgc:136971)
IFU : 128607660(apeh) 128608037(zgc:136971)
PHYP : 113533362(apeh) 113533537
SMEO : 124400033(apeh) 124400352(zgc:136971)
TFD : 113655831(zgc:136971) 113656077
TVC : 132853822(zgc:136971) 132853851
AMEX : 103027063 103034957(apeh)
CMAO : 118813371 118813434(zgc:136971)
EEE : 113578880(apeh) 113589455
CHAR : 105899046(apeh) 105906763(zgc:136971)
TFS : 130530179(zgc:136971) 130530547(apeh)
TNG : GSTEN00008970G001 GSTEN00027959G001
TBEN : 117494241(apeh) 117494520(zgc:136971)
CGOB : 115010464 115010876
PGEO : 117449151(apeh) 117449644(zgc:136971)
GACU : 117540704(apeh) 117541712(zgc:136971)
ELY : 117258664(zgc:136971) 117258822(apeh)
EFO : 125891116(zgc:136971) 125892462(apeh)
PLEP : 121946728(apeh) 121947576(zgc:136971)
SLUC : 116040829(zgc:136971) 116061967(apeh)
ECRA : 117947448(apeh) 117948106(zgc:136971)
PFLV : 114558796 114559445
GAT : 120829723(zgc:136971) 120829838(apeh)
PPUG : 119199468 119222130(zgc:136971) 119223415
AFB : 129099249(zgc:136971) 129099664(apeh)
CLUM : 117733170(apeh) 117733913(zgc:136971)
MSAM : 119905439(apeh) 119905713(zgc:136971)
SCHU : 122882455(apeh) 122883246(zgc:136971)
CUD : 121516962(apeh) 121518003(zgc:136971)
ALAT : 119022257(apeh) 119022628(zgc:136971)
OAU : 116324687(zgc:136971) 116330781(apeh)
OML : 112158935(apeh) 112159656(zgc:136971)
PRET : 103467450 103473525(apeh)
PFOR : 103129855 103155924(apeh)
PLAI : 106956352(apeh) 106959473
PMEI : 106930119 106930477(apeh)
GAF : 122824328(apeh) 122831686(zgc:136971)
PPRL : 129370196(apeh) 129371816(zgc:136971)
CVG : 107094859 107098949(apeh)
CTUL : 119784344(apeh) 119789254(zgc:136971)
GMU : 124873754(zgc:136971) 124875143(apeh)
NFU : 107373674 107390611(apeh)
KMR : 108233030(zgc:136971) 108235266(apeh)
ALIM : 106513079(apeh) 106523903 106523914
NWH : 119417593(apeh) 119417693(zgc:136971)
AOCE : 111570009 111574391
MCEP : 124997898(zgc:136971) 125022208(apeH)
CSEM : 103384671 103384986(apeh)
SSEN : 122776629(zgc:136971) 122777359(apeh)
HHIP : 117764187(zgc:136971) 117764815(apeh)
HSP : 118111009(apeh) 118111426(zgc:136971)
LCF : 108877888 108891729(zgc:136971)
SLAL : 111665104 111668981
XGL : 120804035(apeh) 120804543(zgc:136971)
SSCV : 125988408(zgc:136971) 125988895
PEE : 133399315(zgc:136971) 133413284(apeh)
PTAO : 133474308(zgc:136971) 133489498(apeh)
BPEC : 110164337 110164529
MALB : 109968751 109970409
BSPL : 114858466(apeh) 114858578(zgc:136971)
SJO : 128357799(apeh) 128357894(zgc:136971)
SASA : 106566520(apeh) 106572275
STRU : 115166227 115166228 115166229 115166230 115168544(apeh) 115186142 115186143
OTW : 112215840(zgc:136971) 112222360(apeh)
OMY : 110492560(apeh) 110532073(zgc:136971)
OGO : 124031769(zgc:136971) 124045572(apeh)
ONE : 115101982(apeh) 115131960
OKI : 109868968(apeh) 109907832
OKE : 118359573(apeh) 118361324(zgc:136971)
SALP : 111966270 112075521(apeh)
SNH : 120059455(zgc:136971) 120061445(apeh)
CCLU : 121538145(zgc:136971) 121546083(apeh)
AANG : 118207176(zgc:136971) 118208215
PSPA : 121328622 121329185(apeh)
ARUT : 117411788 117411912 117962413 117964009
PSEX : 120540431(zgc:136971)
LCM : 102351784(APEH) 102352874
CPLA : 122559104(apeh) 122559105
HOC : 132822154 132822383(apeh)
LERI : 129704545(apeh) 129704547
SCLV : 120341819 120342226 120342227
LPIC : 129257537 129257852 129270334
BCOO : 119068143 119080617
TPRE : 106653231 106654148
LBD : 127276976 127287484 127290710
PPYR : 116175611 116175757
API : 100167555 100168218 100169146 100573475
ACOO : 126840215 126841732
HHAL : 106685860 106685861
CBR : CBG_11649(Cbr-dpf-5)
CANU : 128159887 128160239
NVE : 116609737 116609738 5512276
AMIL : 114947681 114947682 114947683
CSAT : 104723745 104732186 109124643
BRP : 103833453 103868336 103872033
BNA : 106349067 106401462 106406252 106415233 106437908 125594955 125603046
BOE : 106300842 106312247 106331151
RSZ : 108818380 108820831 108822763 130498594
MINC : 123210019 123219984
HSYR : 120125821 120151510 120198734
PVU : PHAVU_007G279900g PHAVU_007G280000g
APRC : 113870811 113872585
MTR : 11420124 11429366 25482911
TPRA : 123908384 123908398
PSAT : 127097767 127097769
VVO : 131595779 131595782 131631423 131631425
LJA : Lj0g3v0015409.1(Lj0g3v0015409.1)
AHF : 112719931 112727726 112747534 112793110
LANG : 109325642 109352404
PCIN : 129319629 129319973
PMUM : 103323948 103323950
PAVI : 110763562 110763564
PDUL : 117623090 117623114
MSYL : 126596461 126606772
PALZ : 118056683 118056707
NSY : 104223836 104223837 104224252
NTO : 104096282 104096283 104121104
SSPL : 121774181 121776064 121776171 121777697
ECAD : 122604689 122604718
CQI : 110686144 110718543 110722172 110739376
MING : 122061651 122091191
TSS : 122638728 122638735 122642666
DOSA : Os10t0415800-01(Os10g0415800)
TDC : 119285881 119319613 119322638 119348890
TAES : 123061550 123131769 123135638 123138938 123143221 123182530
LPER : 127309064 127344932
LRD : 124692162 124706220 124706423
SITA : 101784436 101785236
PVIR : 120651052 120688237 120693407
PHAI : 112874717 112875312
MPP : MICPUCDRAFT_53049(JGI:MicpuC2_53049)
SCM : SCHCO_02590080(SCHCODRAFT_02590080) SCHCO_02639825(SCHCODRAFT_02639825)
TIZ : RBU61_06290 RBU61_14720
FBQ : D1817_02860 D1817_13285
APE : APE_1547.1 APE_1832 APE_2290.1
» show all
Taxonomy
Reference
Authors
Tsunasawa S, Narita K, Ogata K.
Title
Purification and properties of acylamino acid-releasing enzyme from rat liver.
Journal
J Biochem (Tokyo) 77:89-102 (1975)
Reference
Authors
Fujino T, Watanabe K, Beppu M, Kikugawa K, Yasuda H.
Title
Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase.
Journal
Reference
Authors
Yamauchi Y, Ejiri Y, Toyoda Y, Tanaka K.
Title
Identification and biochemical characterization of plant acylamino acid-releasing enzyme.
Journal
Reference
Authors
Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z.
Title
Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1.
Journal
Reference
Authors
Shimizu K, Kiuchi Y, Ando K, Hayakawa M, Kikugawa K.
Title
Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins.
Journal
Reference
Authors
Nakai A, Yamauchi Y, Sumi S, Tanaka K.
Title
Role of acylamino acid-releasing enzyme/oxidized protein hydrolase in sustaining homeostasis of the cytoplasmic antioxidative system.
Journal
Reference
Authors
Gogliettino M, Cocca E, Sandomenico A, Gratino L, Iaccarino E, Calvanese L, Rossi M, Palmieri G.
Title
Selective inhibition of acylpeptide hydrolase in SAOS-2 osteosarcoma cells: is this enzyme a viable anticancer target?
Journal
Reference
Authors
Kiss-Szeman AJ, Straner P, Jakli I, Hosogi N, Harmat V, Menyhard DK, Perczel A.
Title
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.1
ExPASy - ENZYME nomenclature database: 3.4.19.1