KEGG   ENZYME: 3.4.19.6
Entry
EC 3.4.19.6                 Enzyme                                 
Name
pyroglutamyl-peptidase II;
thyroliberinase;
pyroglutamyl aminopeptidase II;
thyrotropin-releasing factor pyroglutamate aminopeptidase;
pyroglutamate aminopeptidase II;
pyroglutamyl peptidase II;
thyroliberin-hydrolyzing pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading peptidase;
TRH aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
Reaction(IUBMB)
Release of the N-terminal pyroglutamyl group from pGlu!His-Xaa tripeptides and pGlu!His-Xaa-Gly tetrapeptides
Comment
Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.19.6 created 1992
Orthology
K01306  pyroglutamyl-peptidase II
Genes
HSA29953(TRHDE)
PTR467071(TRHDE)
PPS100977009(TRHDE)
GGO101146939(TRHDE)
PON100460431(TRHDE)
NLE100588911(TRHDE)
HMH116479019(TRHDE)
MCC717653(TRHDE)
MCF102125346(TRHDE)
MTHB126931257
MNI105473361(TRHDE)
CSAB103238733(TRHDE)
CATY105581036(TRHDE)
PANU101004375(TRHDE)
TGE112634595(TRHDE)
MLEU105534154(TRHDE)
RRO104654596(TRHDE)
RBB108528755(TRHDE)
TFN117089730(TRHDE)
PTEH111552360(TRHDE)
CANG105502697(TRHDE)
CJC100415258(TRHDE)
SBQ101052029(TRHDE)
CIMI108290292(TRHDE)
CSYR103264778(TRHDE)
MMUR105856883(TRHDE)
LCAT123640650(TRHDE)
PCOQ105820883(TRHDE)
OGA100957888(TRHDE)
MMU237553(Trhde)
MCAL110303955(Trhde)
MPAH110326499(Trhde)
RNO366894(Trhde)
MCOC116076340(Trhde)
ANU117696836(Trhde)
MUN110562470(Trhde)
CGE100762211(Trhde)
MAUA106022069(Trhde)
PROB127215750(Trhde)
PLEU114699048(Trhde)
MORG121457214(Trhde)
MFOT126497543
AAMP119803600(Trhde)
NGI103735329(Trhde)
HGL101714026(Trhde)
CCAN109699927(Trhde)
DORD105987418(Trhde)
DSP122124257(Trhde)
PLOP125361134(Trhde)
NCAR124982305
MMMA107140049(Trhde)
OCU100352490
OPI101529114(TRHDE)
TUP102488055(TRHDE)
GVR103591950(TRHDE)
CFA481166(TRHDE)
CLUD112677838(TRHDE)
VVP112922179(TRHDE)
VLG121491247(TRHDE)
NPO129511794(TRHDE)
AML100471917(TRHDE)
UMR103656979(TRHDE)
UAH113256259(TRHDE)
UAR123801228
ELK111142230
LLV125107712
MPUF101678354(TRHDE)
MNP132019408(TRHDE)
MLK131839176(TRHDE)
NVS122891829(TRHDE)
ORO101370339(TRHDE)
EJU114199452(TRHDE)
ZCA113922866(TRHDE)
MLX118008554(TRHDE)
NSU110570539(TRHDE)
LWW102735025(TRHDE)
FCA101085556(TRHDE)
PYU121040736(TRHDE)
PCOO112863600(TRHDE)
PBG122474069(TRHDE)
LRUF124502566
PTG102949202(TRHDE)
PPAD109270521(TRHDE)
PUC125919351
AJU106967413
HHV120225282(TRHDE)
BTA100336818(TRHDE)
BOM102279861(TRHDE)
BIU109558307
BBUB102391297(TRHDE)
BBIS104989312(TRHDE)
CHX102175003(TRHDE)
OAS100310794(TRHDE)
BTAX128048450(TRHDE)
ODA120857957(TRHDE)
CCAD122427571(TRHDE)
MBEZ129536959(TRHDE)
SSC100620702(TRHDE)
CFR102512405(TRHDE)
CBAI105072067(TRHDE)
CDK105095993(TRHDE)
VPC102537762(TRHDE)
BACU103006364(TRHDE)
LVE103087695(TRHDE)
OOR101271464(TRHDE)
DLE111173731(TRHDE)
PCAD102992907(TRHDE)
PSIU116761353(TRHDE)
NASI112393946(TRHDE)
ECB100057250(TRHDE)
EPZ103560318(TRHDE)
EAI106822089(TRHDE)
MYB102257792(TRHDE)
MYD102759450(TRHDE)
MMYO118651540(TRHDE)
MLF102443333(TRHDE)
MNA107526667(TRHDE)
PKL118728986(TRHDE)
EFUS103298764(TRHDE)
HAI109387696(TRHDE)
DRO112319112(TRHDE)
SHON118989336(TRHDE)
AJM119055865(TRHDE)
PDIC114513224(TRHDE)
PHAS123812690(TRHDE)
MMF118624261(TRHDE)
RFQ117029045(TRHDE)
PPAM129075896(TRHDE)
PALE102892053(TRHDE)
PGIG120605081(TRHDE)
PVP105301649(TRHDE)
RAY107512623(TRHDE)
MJV108391359(TRHDE)
TOD119247501(TRHDE)
SARA101552336(TRHDE)
LAV100670199(TRHDE)
TMU101357589
ETF101662314(TRHDE)
DNM101431696(TRHDE)
MDO100016797(TRHDE)
GAS123250169(TRHDE)
SHR105750663(TRHDE)
AFZ127537911
PCW110195938(TRHDE)
OAA100079276(TRHDE)
GGA427868(TRHDE)
PCOC116226747(TRHDE)
MGP100550266(TRHDE)
CJO107310276(TRHDE)
TPAI128073425(TRHDE)
LMUT125691584(TRHDE)
NMEL110392825(TRHDE)
APLA101793030(TRHDE)
ACYG106046722(TRHDE)
CATA118246891(TRHDE)
AFUL116502254(TRHDE)
TGU100230387(TRHDE)
LSR110469833(TRHDE)
SCAN103813667(TRHDE)
PMOA120499909(TRHDE)
OTC121339493(TRHDE)
PRUF121352574(TRHDE)
GFR102039975(TRHDE)
FAB101811314(TRHDE)
OMA130248553(TRHDE)
PHI102104144(TRHDE)
PMAJ107204601(TRHDE)
CCAE111932896(TRHDE)
CCW104698393(TRHDE)
CBRC103614825(TRHDE)
ETL114059991(TRHDE)
ZAB102068008(TRHDE)
SVG106855036(TRHDE)
MMEA130580429(TRHDE)
HRT120752074(TRHDE)
FPG101921757(TRHDE)
FCH102050378(TRHDE)
CLV102089579(TRHDE)
EGZ104132924(TRHDE)
NNI104010989(TRHDE)
PCAO104046210(TRHDE)
ACUN113489363(TRHDE)
TALA104359340(TRHDE)
PADL103919943(TRHDE)
AFOR103893909(TRHDE)
ACHC115336290(TRHDE)
HLE104828329(TRHDE)
AGEN126034375
GCL127021586
MNB103776713
OHA104326752(TRHDE)
SHAB115605581(TRHDE)
DPUB104300969(TRHDE)
CPEA104393561(TRHDE)
AVIT104279401(TRHDE)
CVF104288906(TRHDE)
RTD128904192(TRHDE)
CUCA104063936(TRHDE)
BRHI104491282(TRHDE)
AAM106488685(TRHDE)
AROW112964094(TRHDE)
NPD112958846(TRHDE)
TGT104577007(TRHDE)
DNE112983320(TRHDE)
SCAM104140676(TRHDE)
ASN102377345(TRHDE)
AMJ102572757(TRHDE)
CPOO109315969(TRHDE)
GGN109296374(TRHDE)
PSS102455963(TRHDE)
CMY102929819(TRHDE)
CCAY125630177(TRHDE)
DCC119850076(TRHDE)
CPIC101933457(TRHDE)
TST117877919(TRHDE)
CABI116817170(TRHDE)
MRV120395815(TRHDE)
ACS100551808(trhde)
ASAO132776151(TRHDE)
PVT110085004(TRHDE)
SUND121932253(TRHDE)
PBI103057029(TRHDE)
PMUR107283818(TRHDE)
CTIG120308417(TRHDE)
TSR106554017(TRHDE)
PGUT117655737(TRHDE)
APRI131202260(TRHDE)
PTEX113435552(TRHDE)
NSS113412244(TRHDE)
VKO123033281(TRHDE)
PMUA114604978(TRHDE)
PRAF128421860(TRHDE)
ZVI118091478(TRHDE)
HCG128327271(TRHDE)
GJA107115337(TRHDE)
STOW125435820(TRHDE)
EMC129336070(TRHDE)
XLA108705027(trhde.L) 108713143(trhde.S)
XTR100489066(trhde)
NPR108788310(TRHDE)
RTEM120931963(TRHDE)
BBUF120980741(TRHDE)
BGAR122928000(TRHDE)
MUO115477764(TRHDE)
GSH117363666(TRHDE)
DRE100006808(trhde.1) 562409(trhde.2)
SRX107710667 107710683 107737850 107737851
SANH107666938 107692246 107694150(trhde)
SGH107556776 107556777 107590972
CCAR109064695 109088706
CAUA113048225 113061661
CGIB127956899 127956968 127972926
PTET122342787 122343504
LROH127164468
OMC131539125
PPRM120476935(trhde.1) 120476938
RKG130082679 130082681
MAMB125245225 125246445
CIDE127511012 127511335
MASI127435401 127435402 127435403 127436826 127436827
TROS130547662 130547663 130548116
TDW130420645 130421265
MANU129432078 129432171
IPU108279435 108279600 108279602
IFU128622956 128622957 128622969
PHYP113531778(trhde)
SMEO124400994 124400999
TFD113647232 113651581
TVC132859336 132859356
AMEX103029429(trhde)
CMAO118812328
EEE113569187(trhde)
CHAR105892297
TRU101065693(trhde)
TFS130519206
TNGGSTEN00034648G001
LCO104931506(trhde)
TBEN117485200
ELY117249410
EFO125882777
PLEP121961419
SLUC116047901
ECRA117939069
ESP116673112(trhde)
PFLV114550090(trhde)
GAT120817178
PPUG119210728
AFB129112655
CLUM117726202
MSAM119895745
SCHU122871443
CUD121505825
ALAT119032362(trhde.2)
MZE101477232(trhde)
ONL100692659(trhde)
OAU116312826(trhde.2)
OLA101170139(trhde)
OML112152862
XMA102225911(trhde)
XCO114160787(trhde)
XHE116736546(trhde)
PRET103459315(trhde)
PFOR103155878(trhde)
PLAI106957563(trhde)
PMEI106925013(trhde)
GAF122826410
PPRL129352825
CVG107090612(trhde)
CTUL119790590
GMU124883040
NFU107386826(trhde)
KMR108250579
ALIM106526106(trhde)
NWH119428592
AOCE111564467
MCEP125000203
CSEM103382523(trhde)
SSEN122766794
HHIP117757011
HSP118101836
LCF108895871
SDU111224541(trhde)
SLAL111665930(trhde)
XGL120797455
HCQ109532578
SSCV125991930
SBIA133493950
PEE133397436
PTAO133471785
BPEC110161508(trhde)
MALB109952969(trhde)
BSPL114862500
STRU115189734(trhde)
OMY110499725 110512778
OKI116360588(trhde)
SNH120041567
CCLU121553366
ELS105023119(trhde)
SFM108936360(trhde) 108942250
PKI111851702(trhde) 111858635
AANG118219164 118231096
LOC102694815(trhde)
PSPA121318038 121320055
ARUT117414806 117419986
PSEX120534371
LCM102356972(TRHDE)
CMK103185331
RTP109927660(trhde)
CPLA122559754
HOC132824658
LERI129706438
PMRN116945538(TRHDE)
LRJ133351474(TRHDE)
BFO118411680 118412679
BBEL109468363 109468583
SPU588093
LPIC129259693
SKO100372228
AARA120894355
AMER121594694
ASTE118512318
ACER107993193
ALAB122719033
ADR102671536
AFLR100867315
BAFF126928998
BPAS132909042
MGEN117225526
HST105188811
LHU105673232 105673248
PGC109858688 109859933 109860632 109860980
OBO105285042
CGLO123265802
AGIF122853999
DCI103505022
HHAL106686132
MQU128982403 128998122 128998554 128998678
DMK116926394
DSV119440785 119440786
RMP119164395 119164400 119165349 119165350
RPHI132727056 132727158
 » show all
Reference
1  [PMID:115687]
  Authors
Bauer K, Nowak P.
  Title
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
  Journal
Eur J Biochem 99:239-46 (1979)
DOI:10.1111/j.1432-1033.1979.tb13250.x
Reference
2  [PMID:2862039]
  Authors
O'Connor B, O'Cuinn G
  Title
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain.
  Journal
Eur J Biochem 150:47-52 (1985)
DOI:10.1111/j.1432-1033.1985.tb08986.x
Reference
3  [PMID:20504468]
  Authors
Wilk S, Wilk EK
  Title
Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme.
  Journal
Neurochem Int 15:81-9 (1989)
DOI:10.1016/0197-0186(89)90079-X
Other DBs
ExplorEnz - The Enzyme Database: 3.4.19.6
IUBMB Enzyme Nomenclature: 3.4.19.6
ExPASy - ENZYME nomenclature database: 3.4.19.6
BRENDA, the Enzyme Database: 3.4.19.6
CAS: 60063-88-9

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