KEGG ENZYME: 3.4.21.117

ENZYME: 3.4.21.117

Entry

EC 3.4.21.117               Enzyme

Name

stratum corneum chymotryptic enzyme;
kallikrein 7;
SCCE;
KLK7;
PRSS6;
hK7

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Cleavage of proteins with aromatic side chains in the P1 position

Comment

This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6!Cya7, Tyr16!Leu17, Phe25!Tyr26 and Tyr26!Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.

History

EC 3.4.21.117 created 2006

Orthology

K08668

kallikrein 7

Genes

HSA:	5650(KLK7)

PTR:	468973(KLK7)

PPS:	117974257(KLK7)

PON:	100173841(KLK7)

NLE:	115837077(KLK7)

HMH:	116478144(KLK7)

MCC:	722683(KLK7)

MCF:	102134711(KLK7)

MTHB:

126943167

MNI:	105497132(KLK7)

CSAB:

103235545(KLK7)

CATY:

105595347(KLK7)

PANU:

101010585(KLK7)

TGE:	112612567(KLK7)

MLEU:

105528932(KLK7)

RBB:	108532427(KLK7)

TFN:	117091656(KLK7)

PTEH:

111520075(KLK7)

CANG:

105514845(KLK7)

CJC:	103790022(KLK7)

SBQ:	101047010(KLK7)

CIMI:

108291978(KLK7)

CSYR:

103274731(KLK7)

MMUR:

105865566(KLK7)

LCAT:

123624203(KLK7)

PCOQ:

105809351(KLK7)

OGA:	100953428(KLK7)

MMU:	23993(Klk7)

MCAL:

110297559(Klk7)

MCOC:

116102107(Klk7)

ANU:	117711216(Klk7)

MUN:	110553719(Klk7)

CGE:

100753553

MAUA:

101839422(Klk7)

PROB:

127213756(Klk7)

PLEU:

114683920(Klk7)

MORG:

121464177(Klk7)

MFOT:

126488152

NGI:	103743766(Klk7)

HGL:	101705516(Klk7)

CPOC:

100716524

CCAN:

109683887(Klk7)

DORD:

105994170(Klk7)

DSP:	122125636(Klk7)

PLOP:

125338535(Klk7)

MMMA:

107151204(Klk7)

OPI:	101536049(KLK7)

TUP:	102467699(KLK7)

GVR:	103597730(KLK7)

CFA:	611780(KLK7)

CLUD:

112645078(KLK7)

VVP:	112931315(KLK7)

VLG:	121484999(KLK7)

NPO:	129500972(KLK7)

AML:	100476432(KLK7)

UMR:	103657286(KLK7)

UAH:	113247320(KLK7)

UAR:	123778003(KLK7)

ELK:

111160642

LLV:

125089995

MPUF:

101689559(KLK7)

MNP:	132004736(KLK7)

MLK:	131817588(KLK7)

NVS:	122911772(KLK7)

ORO:	101382840(KLK7)

EJU:	114199593(KLK7)

ZCA:	113935398(KLK7)

MLX:	117997971(KLK7)

NSU:

110572974

LWW:

102747095

FCA:	101088894(KLK7)

PYU:	121018992(KLK7)

PCOO:

112851205

PBG:	122493799(KLK7)

PVIV:

125153163(KLK7)

LRUF:

124510866

PTG:	102964470(KLK7)

PPAD:

109252987(KLK7)

PUC:

125915706

AJU:

106989674

HHV:	120242514(KLK7)

BTA:	506380(KLK7)

BOM:	102282184(KLK7)

BIU:	109571922(KLK7)

BBUB:

102402696(KLK7)

BBIS:

104995698(KLK7)

CHX:	102178562(KLK7)

OAS:	101115562(KLK7)

BTAX:

128063380(KLK7)

ODA:	120872032(KLK7)

CCAD:

122421641(KLK7)

MBEZ:

129546487(KLK7)

SSC:	100359349(KLK7)

CFR:

116666014

CBAI:

105062680(KLK7)

CDK:	105100155(KLK7)

VPC:	102543983(KLK7)

BACU:

102998157(KLK7)

BMUS:

118885406(KLK7)

LVE:	103070574(KLK7)

OOR:	101276423(KLK7)

DLE:

111180508

PCAD:

102981921(KLK7)

PSIU:

116744066

NASI:

112415501

ECB:	100146194(KLK7)

EPZ:	103567752(KLK7)

EAI:	106847578(KLK7)

MYB:	102249473 102249777 102250372 102251959(KLK7) 106728162

MYD:	102764448 102764733(KLK7) 102766856 102768344 102768913 107183018

MMYO:

118649156 118649157 118649158 118649160 118649272(KLK7) 118649295

MLF:	102421368 102436334 102437574 102437871 102443309 111823018

PKL:	118714916 118714919 118714928 118714929 118714930

EFUS:

103297599 103297741 103297742 103297743 114227342 129147585 129147787 129147788 129147789

MNA:	107531777 107531778 107531827

DRO:

112310145

AJM:	119052002 119052019

PDIC:

114510585 114510586 114510961

PHAS:

123830223 123830323 123830326

MMF:	118638353 118638857

PPAM:

129082706 129082707 129082817 129085214

HAI:	109391010(KLK7)

RFQ:	117035628 117035632

PALE:

102897729

PGIG:

120584010(KLK7) 120592205

PVP:

105307412

RAY:

107500473

MJV:

108386820

SARA:

101548965(KLK7)

LAV:

100666907

TMU:

101345301

ETF:

105979344

DNM:	101421440(KLK7)

MDO:	100012470(KLK7)

GAS:	123242909(KLK7)

SHR:	100933396 100933649

AFZ:	127556451 127556452

PCW:	110220142(KLK7)

OAA:	100079028(KLK7)

CCRI:

104166386

AARA:

120894996

AMER:

121592359

AMOU:

128302198

VCAN:

122409359

AGRG:

126744916

CSET:

123307692 123318857 123319134

SLIU:

111352703

CCRN:

123297558 123299726

HVI:	124360535 124372881

IEL:

124157851

EAF:

111706198

» show all

Reference

1 [PMID:7794273]

Authors

Skytt A, Stromqvist M, Egelrud T.

Title

Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.

Journal

Biochem Biophys Res Commun 211:586-9 (1995)
DOI:10.1006/bbrc.1995.1853

Sequence

[hsa:5650]

Reference

2 [PMID:8393902]

Authors

Egelrud T.

Title

Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation.

Journal

J Invest Dermatol 101:200-4 (1993)
DOI:10.1111/1523-1747.ep12363804

Reference

3 [PMID:8034709]

Authors

Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T.

Title

Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

Journal

J Biol Chem 269:19420-6 (1994)

Sequence

[hsa:5650]

Reference

4 [PMID:10974542]

Authors

Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP.

Title

The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation.

Journal

Gene 254:119-28 (2000)
DOI:10.1016/S0378-1119(00)00280-8

Sequence

[hsa:5650]

Reference

5 [PMID:15191543]

Authors

Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R.

Title

Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.

Journal

J Invest Dermatol 123:62-6 (2004)
DOI:10.1111/j.0022-202X.2004.22708.x

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.117

IUBMB Enzyme Nomenclature:

3.4.21.117

ExPASy - ENZYME nomenclature database:

3.4.21.117

BRENDA, the Enzyme Database:

3.4.21.117

CAS:	155215-90-0

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Gene (228)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (201)   
   KEGG MGENES (5)   
   RefGene (21)   
Protein sequence (51)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (6)   
   PDBSTR (41)   
DNA sequence (7)   
   RefSeq(nuc) (6)   
   GenBank (1)   
3D Structure (15)   
   PDB (15)   
Protein domain (6)   
   InterPro (6)   
All databases (307)   

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