KEGG   ENZYME: 3.4.21.119
Entry
EC 3.4.21.119               Enzyme                                 
Name
kallikrein 13;
KLK13;
kallikrein mK13;
mGK-13;
mK13;
mKLK13;
prorenin converting enzyme 1;
PRECE-1;
prorenin-converting enzyme;
PRECE;
proteinase P
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg! pair in the N-terminus, to yield mature renin
Comment
The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.
History
EC 3.4.21.119 created 2006
Orthology
K09462  glandular kallikrein 13
K09463  kallikrein 13
Genes
HSA26085(KLK13)
PTR748200(KLK13)
PPS103785249(KLK13)
GGO101150353(KLK13)
PON100438457(KLK13)
NLE100590429(KLK13)
HMH116478131(KLK13)
MCC106994830(KLK13)
MCF102147127(KLK13)
MTHB126943172
MNI105497126(KLK13)
CSAB103235116(KLK13)
CATY105595353(KLK13)
PANU101010957(KLK13)
TGE112612965(KLK13)
MLEU105528926(KLK13)
RRO104667255(KLK13)
RBB108515163
TFN117091664(KLK13)
PTEH111520159(KLK13)
CANG105514714(KLK13)
CJC100404986(KLK13)
SBQ101048919(KLK13)
CIMI108291972(KLK13)
CSYR103274747(KLK13)
MMUR105865555(KLK13)
LCAT123624202(KLK13)
PCOQ105809347(KLK13)
OGA105888336(KLK13)
MMU13647(Egfbp2) 626834(Klk13)
MCAL110297555(Klk13)
MPAH110334543(Klk13)
RNO292848(Klk13)
MCOC116100488(Klk13)
ANU117703334(Klk13)
MUN110553708(Klk13)
CGE100761429(Klk13)
MAUA101841402(Klk13)
PROB127213891(Klk13)
PLEU114683931(Klk13)
MORG121450399(Klk13)
MFOT126488187
AAMP119802875(Klk13)
NGI103743721(Klk13)
HGL101704794(Klk13)
CPOC100715865(Klk13)
CCAN109683888(Klk13)
DORD105994288(Klk13)
DSP122125635(Klk13)
PLOP125338531(Klk13)
NCAR124967592
MMMA107151544
OPI101522907(KLK13)
TUP102490552(KLK13)
GVR103597725
CFA100856194(KLK13)
CLUD112645063(KLK13)
VVP112931504(KLK13)
VLG121485536(KLK13)
NPO129500597(KLK13)
AML100475439(KLK13)
UMR103657290(KLK13)
UAH113247319(KLK13)
UAR123778032(KLK13)
ELK111160751
LLV125089893
MPUF101686517(KLK13)
MNP132004925(KLK13)
MLK131817576(KLK13)
NVS122911766(KLK13)
ORO101378198(KLK13)
EJU114199580(KLK13)
ZCA113935388(KLK13)
MLX117998330(KLK13)
NSU110572994(KLK13)
LWW102745891
FCA102902318(KLK13)
PYU121018979(KLK13)
PCOO112850835(KLK13)
PBG122493792(KLK13)
LRUF124511920
PTG102966011(KLK13)
PPAD109252979(KLK13)
PUC125915707
AJU106989681
HHV120242195(KLK13)
BTA540297(KLK13)
BOM102280496(KLK13)
BIU109571793(KLK13)
BBUB102399235(KLK13)
BBIS104995704(KLK13)
CHX102180530(KLK13)
OAS101120106(KLK13)
BTAX128063390(KLK13)
ODA120872023
CCAD122420826(KLK13)
MBEZ129546480(KLK13)
SSC110261032(KLK13)
CFR102520551(KLK13)
CBAI105062685(KLK13)
CDK105100150(KLK13)
VPC102530731(KLK13)
BACU102997885(KLK13)
PCAD102983224(KLK13)
ECB100067063(KLK13)
EPZ103567745(KLK13)
EAI106847521(KLK13)
MYB102245547(KLK13)
MYD102763838(KLK13)
MLF102439648(KLK13)
MNA107531819(KLK13)
PKL118714910(KLK13)
EFUS103297594(KLK13)
HAI109391035(KLK13)
DRO112310174
AJM119052020(KLK13)
PDIC114511505(KLK13)
PHAS123830299
MMF118638346(KLK13)
RFQ117035641(KLK13)
PPAM129082821
PALE102897491(KLK13)
PGIG120584016(KLK13)
PVP105311323
RAY107500471(KLK13)
MJV108409529(KLK13)
TOD119249650(KLK13)
SARA101550025(KLK13)
ETF101641548
DNM105745980
MDO100028184(KLK13)
GAS123242913(KLK13)
SHR105749001(KLK13)
AFZ127557579
PCW110219944(KLK13)
OAA100082666(KLK13)
PMOA120511634
CLV102091959
PLET104617942
TALA116962463 122153826 122153829
OHA104334555
CVF104287815
PRET103462834
PFOR103131593 103131598
PLAI106934988
PMEI106905726
AGIF122848296
VCAN122417355
CSET123318855
PPYR116179573
BMOR101744780
BMAN114250725
MSEX115453268
BANY112050571
MCIX123665327
PMAC106714794
PPOT106103148
PXU106128884
ZCE119837165
LSIN126969937
HAW110377627
RMD113557869
 » show all
Reference
1  [PMID:2250008]
  Authors
Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K.
  Title
Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.
  Journal
J Biol Chem 265:21027-31 (1990)
Reference
2  [PMID:2180937]
  Authors
Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K.
  Title
A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization.
  Journal
J Biol Chem 265:5930-3 (1990)
Reference
3  [PMID:9507064]
  Authors
Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K.
  Title
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).
  Journal
Biochim Biophys Acta 1382:55-64 (1998)
DOI:10.1016/S0167-4838(97)00144-1
Reference
4  [PMID:16423834]
  Authors
Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K
  Title
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.
  Journal
J Biol Chem 281:7968-76 (2006)
DOI:10.1074/jbc.M507705200
  Sequence
[mmu:626834]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.119
IUBMB Enzyme Nomenclature: 3.4.21.119
ExPASy - ENZYME nomenclature database: 3.4.21.119
BRENDA, the Enzyme Database: 3.4.21.119
CAS: 342900-44-1

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