KEGG   ENZYME: 3.4.21.121
Entry
EC 3.4.21.121               Enzyme                                 
Name
Lys-Lys/Arg-Xaa endopeptidase;
ASP (Aeromonas sobria)-type peptidase;
Aeromonas extracellular serine protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage of -Lys-Lys! and -Lys-Arg! bonds.
Comment
The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.
History
EC 3.4.21.121 created 2013
Orthology
K20755  Lys-Lys/Arg-Xaa endopeptidase
Genes
SCOT: HBA18_10945
SPRO: N7E60_11475
PVB: J5X90_13770
AHA: AHA_2687
AHY: AHML_14260
AHD: AI20_06005
AHR: V428_14760
AHP: V429_14780
AHJ: V469_08330
AHH: RY45_14125
AHI: VU14_08305
AAJ: BOQ57_13770
ASA: ASA_2540(ahe2)
AEO: O23A_p0913
AVR: B565_1490
AVO: AMS64_14825
ADH: CK627_12390
AEM: CK911_04765
AEL: NCTC12917_02520(ahe2)
AALL: I6G90_07645
AJD: I6H43_02245
AEJ: E5E97_18765
ABES: IU367_08245
 » show all
Reference
1  [PMID:19654332]
  Authors
Kobayashi H, Utsunomiya H, Yamanaka H, Sei Y, Katunuma N, Okamoto K, Tsuge H
  Title
Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.
  Journal
J Biol Chem 284:27655-63 (2009)
DOI:10.1074/jbc.M109.006114
  Sequence
[ag:AAF64521]
Reference
2  [PMID:18067862]
  Authors
Nitta H, Kobayashi H, Irie A, Baba H, Okamoto K, Imamura T
  Title
Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria.
  Journal
FEBS Lett 581:5935-9 (2007)
DOI:10.1016/j.febslet.2007.11.076
Reference
3  [PMID:16487335]
  Authors
Kobayashi H, Takahashi E, Oguma K, Fujii Y, Yamanaka H, Negishi T, Arimoto-Kobayashi S, Tsuji T, Okamoto K
  Title
Cleavage specificity of the serine protease of Aeromonas sobria, a member of the  kexin family of subtilases.
  Journal
FEMS Microbiol Lett 256:165-70 (2006)
DOI:10.1111/j.1574-6968.2006.00134.x
Reference
4  [PMID:18462393]
  Authors
Imamura T, Nitta H, Wada Y, Kobayashi H, Okamoto K
  Title
Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria.
  Journal
FEMS Microbiol Lett 284:35-42 (2008)
DOI:10.1111/j.1574-6968.2008.01184.x
Reference
5  [PMID:18714034]
  Authors
Nitta H, Imamura T, Wada Y, Irie A, Kobayashi H, Okamoto K, Baba H
  Title
Production of C5a by ASP, a serine protease released from Aeromonas sobria.
  Journal
J Immunol 181:3602-8 (2008)
DOI:10.4049/jimmunol.181.5.3602
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.121
IUBMB Enzyme Nomenclature: 3.4.21.121
ExPASy - ENZYME nomenclature database: 3.4.21.121
BRENDA, the Enzyme Database: 3.4.21.121

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Gene (514)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (24)   
   RefGene (489)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (9)   
   InterPro (9)   
All databases (525)   

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