KEGG   ENZYME: 3.4.21.27
Entry
EC 3.4.21.27                Enzyme                                 
Name
coagulation factor XIa;
blood-coagulation factor XIa;
activated blood-coagulation factor XI;
activated plasma thromboplastin antecedent
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ala and Arg!Val bonds in factor IX to form factor IXa
Comment
In peptidase family S1 (trypsin family), and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa
History
EC 3.4.21.27 created 1978
Orthology
K01323  coagulation factor XI
Genes
HSA: 2160(F11)
PTR: 461643(F11)
PPS: 100986597(F11)
GGO: 101144810(F11)
PON: 100443368(F11)
NLE: 100594390(F11)
HMH: 116466088(F11)
MCC: 702117(F11)
MCF: 102143421(F11)
MTHB: 126955235
MNI: 105466551(F11)
CSAB: 103236638(F11)
CATY: 105594266(F11)
PANU: 101004898(F11)
TGE: 112624869(F11)
MLEU: 105540241(F11)
RRO: 104673818(F11)
RBB: 108522438(F11)
TFN: 117086227(F11)
PTEH: 111548504(F11)
CANG: 105524321(F11)
CJC: 100409213(F11)
SBQ: 101048656(F11)
CIMI: 108288138(F11)
CSYR: 103271966(F11)
MMUR: 105882475(F11)
LCAT: 123638617(F11)
PCOQ: 105810113(F11)
OGA: 100950428(F11)
MMU: 109821(F11)
MCAL: 110300267(F11)
MPAH: 110337055(F11)
RNO: 290757(F11)
MCOC: 116071382(F11) 116104793
ANU: 117721640(F11)
MUN: 110558005(F11)
CGE: 100768163(F11)
MAUA: 101842487(F11)
PROB: 127220496(F11)
PLEU: 114701163(F11)
MORG: 121433836
MFOT: 126504772
AAMP: 119811329(F11)
NGI: 103750494(F11)
HGL: 101717554(F11)
CPOC: 100715511(F11)
CCAN: 109684333(F11)
DORD: 105992270(F11)
PLOP: 125339615(F11)
NCAR: 124983858
MMMA: 107142649
OCU: 100009596(F11)
OPI: 101523581
TUP: 102486112(F11)
CFA: 475623(F11)
CLUD: 112675194
VVP: 112934788(F11)
VLG: 121489579
NPO: 129503581(F11)
AML: 100468102(F11)
UMR: 103681005(F11)
UAH: 113262289
UAR: 123784491(F11)
ELK: 111144552
LLV: 125092307
MPUF: 101689719(F11)
MNP: 132006404(F11)
MLK: 131820555(F11)
NVS: 122919284(F11)
ORO: 101379606(F11)
EJU: 114206166(F11)
ZCA: 113924885(F11)
MLX: 118010047(F11)
NSU: 110584167(F11)
LWW: 102727030(F11)
FCA: 101094340(F11)
PYU: 121039711
PCOO: 112869961(F11)
PBG: 122471014(F11)
PVIV: 125164435
LRUF: 124520885
PTG: 102971589(F11)
PPAD: 109250989(F11)
PUC: 125923455
AJU: 106982228
HHV: 120237792(F11)
BTA: 407998(F11)
BOM: 102269276(F11)
BIU: 109553537(F11)
BBUB: 102397200(F11)
BBIS: 104985563(F11)
CHX: 102184496(F11)
OAS: 101116630
BTAX: 128068329(F11)
ODA: 120865744(F11)
CCAD: 122432619(F11)
MBEZ: 129549325
SSC: 110257404(F11)
CFR: 102512586(F11)
CBAI: 105067665(F11)
CDK: 105102382(F11)
VPC: 102545603
BACU: 103000341(F11)
BMUS: 118888004(F11)
LVE: 103081629(F11)
OOR: 101278094
DLE: 111173428
PCAD: 102991372(F11)
PSIU: 116746668(F11)
NASI: 112409698(F11)
ECB: 100056603(F11)
EPZ: 103543237(F11)
EAI: 106840364(F11)
MYB: 102250308(F11)
MYD: 102765408(F11)
MNA: 107534053(F11)
SHON: 118993097(F11)
AJM: 119036847(F11)
PDIC: 114508872(F11)
PHAS: 123807511(F11)
PPAM: 129064873(F11)
PALE: 102886513
PVP: 105294726
MJV: 108396404(F11)
TOD: 119257003(F11)
SARA: 101551126(F11)
LAV: 100660487
ETF: 101658076(F11)
DNM: 101436686(F11)
MDO: 100013939(F11)
GAS: 123251469(F11)
SHR: 100914754(F11)
PCW: 110195650
OAA: 100089965
IPU: 108257189
PHYP: 113536074
TRU: 101065630 101079225 101079451 115251705
LCO: 104920427
MSAM: 119907799 119907800
XMA: 111609537
KMR: 108238782
ALIM: 106532068 106532069
POV: 109631873
BPEC: 110167400
CIN: 100184334
AALB: 109409339 109419086 115266916
VEM: 105559925
TCA: 664603
ATD: 109595979
BANY: 112047025
ZCE: 119838989
OFU: 114355248
PVM: 113827485
HRO: HELRODRAFT_181511
BGT: 106077908
HRF: 124116290
 » show all
Reference
1
  Authors
Kurachi, K. and Davie, E.W.
  Title
Human factor XI (plasma thromboplastin antecedent).
  Journal
Methods Enzymol 80:211-220 (1981)
Reference
2  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Reference
3  [PMID:3636155]
  Authors
Fujikawa K, Chung DW, Hendrickson LE, Davie EW
  Title
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.
  Journal
Biochemistry 25:2417-24 (1986)
DOI:10.1021/bi00357a018
  Sequence
[hsa:2160]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.27
IUBMB Enzyme Nomenclature: 3.4.21.27
ExPASy - ENZYME nomenclature database: 3.4.21.27
BRENDA, the Enzyme Database: 3.4.21.27
CAS: 37203-61-5

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