KEGG ENZYME: 3.4.21.37

ENZYME: 3.4.21.37

Entry

EC 3.4.21.37                Enzyme

Name

leukocyte elastase;
lysosomal elastase;
neutrophil elastase;
polymorphonuclear leukocyte elastase;
elastase;
elaszym;
serine elastase;
granulocyte elastase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including elastin. Preferential cleavage Val! > Ala!

Comment

Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11

History

EC 3.4.21.37 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)

Orthology

K01327

leukocyte elastase

Genes

HSA:	1991(ELANE)

PPS:	100969272(ELANE)

PON:	100452808(ELANE)

NLE:	100595921(ELANE)

HMH:	116482905(ELANE)

MCC:	106992354(ELANE)

MCF:	102135637(ELANE)

MTHB:

126942977

MNI:	105486435(ELANE)

CSAB:

103233572(ELANE)

CATY:

105591688(ELANE)

TGE:	112612320(ELANE)

MLEU:

105532878(ELANE)

RRO:	104671432(ELANE)

RBB:	108537896(ELANE)

TFN:	117074366(ELANE)

PTEH:

111534745(ELANE)

CANG:

105527607(ELANE)

CJC:	100389262(ELANE)

SBQ:	101030517(ELANE)

CIMI:

108293190(ELANE)

MMUR:

105860756(ELANE)

LCAT:

123632351(ELANE)

PCOQ:

105811217(ELANE)

OGA:	100965078(ELANE)

MMU:	50701(Elane)

MCAL:

110304016(Elane)

MPAH:

110326943(Elane)

RNO:	299606(Elane)

MCOC:

116076175

ANU:

117696369

MUN:	110551370(Elane)

CGE:	100752732(Elane)

MAUA:

106022252(Elane)

PROB:

127216810

PLEU:

114684136(Elane)

MORG:

121459202(Elane)

MFOT:

126489243

AAMP:

119815440

NGI:

103737354

HGL:	101705441 101715199(Elane)

CPOC:

100724414

CCAN:

109693670

DSP:

122122820

PLOP:

125348533

MMMA:

107157229

OCU:

127490148

OPI:

101525948

TUP:	102488298(ELANE)

GVR:	103607669(ELANE)

CFA:	442980(ELANE)

CLUD:

112666918

VVP:

112935508

VLG:

121496213

NPO:

129521404

AML:

105234312

UMR:

103681765

UAH:	113242651(ELANE)

UAR:

123794053

LLV:

125087398

MPUF:

101684702

MNP:

132009634

MLK:

131825709

NVS:

122910277

ORO:

101375336

EJU:

114226239

ZCA:

113916132

MLX:

118005404

NSU:

110594100

LWW:

102729363

FCA:	100301482(ELANE)

PYU:	121021310(ELANE)

PBG:

122486349

PVIV:

125159748

LRUF:

124527663

PTG:	102951727(ELANE)

PPAD:

109257711

PUC:

125928787

AJU:

113597259

HHV:

120242411

BTA:	100126050(ELANE)

BOM:	102274925(ELANE)

BBUB:

102411920(ELANE)

BBIS:

104991906(ELANE)

CHX:	102173292(ELANE)

OAS:	101110841(ELANE)

BTAX:

128051781(ELANE)

ODA:	120864495(ELANE)

MBEZ:

129558743(ELANE)

SSC:	100522182(ELANE)

CFR:

102507529

CBAI:

105078346

CDK:	105106576(ELANE)

VPC:	102529857(ELANE)

BACU:

103003856(ELANE)

BMUS:

118892699(ELANE)

LVE:	103074519(ELANE)

OOR:	101272927(ELANE)

DLE:	111170497(ELANE)

PCAD:

102995281(ELANE)

PSIU:

116750552(ELANE)

NASI:

112396312

ECB:	111774155(ELANE)

EPZ:	103544822(ELANE)

EAI:	106834239(ELANE)

MYB:	106723590(ELANE)

MYD:	102756029(ELANE)

MMYO:

118658984(ELANE)

MLF:	102437746(ELANE)

PKL:	118711780(ELANE)

EFUS:

103294436(ELANE)

MNA:	107538546(ELANE)

DRO:	112312421(ELANE)

SHON:

118984390(ELANE)

AJM:

119044598

PDIC:

114503126

MMF:	118616311(ELANE)

PPAM:

129080092(ELANE)

HAI:	109390590(ELANE)

RFQ:	117038398(ELANE)

PALE:

102888696(ELANE)

PGIG:

120583673(ELANE)

RAY:

107500956

MJV:

108395534

TOD:

119240359

LAV:	100672001(ELANE)

TMU:

101350466

ETF:

101653944

DNM:

101412103

MDO:	100030465(ELANE)

GAS:

123232212

AFZ:

127545084

PCW:	110196241(ELANE)

OAA:

791113

XTR:	448597(prtn3)

AGIF:

122856252

» show all

Reference

1 [PMID:7043201]

Authors

Barrett AJ.

Title

Leukocyte elastase.

Journal

Methods Enzymol 80 Pt C:581-8 (1981)
DOI:10.1016/s0076-6879(81)80046-8

Reference

2 [PMID:6380580]

Authors

Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.

Title

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.

Journal

Biochemistry 23:2995-3002 (1984)
DOI:10.1021/bi00308a023

Reference

3 [PMID:3646070]

Authors

Stein RL, Strimpler AM, Hori H, Powers JC.

Title

Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.

Journal

Biochemistry 26:1301-5 (1987)
DOI:10.1021/bi00379a015

Reference

4 [PMID:2655701]

Authors

Bode W, Meyer E Jr, Powers JC.

Title

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.

Journal

Biochemistry 28:1951-63 (1989)
DOI:10.1021/bi00431a001

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.37

IUBMB Enzyme Nomenclature:

3.4.21.37

ExPASy - ENZYME nomenclature database:

3.4.21.37

BRENDA, the Enzyme Database:

3.4.21.37

CAS:

9004-06-2

DBGET integrated database retrieval system