KEGG ENZYME: 3.4.21.39

ENZYME: 3.4.21.39

Entry

EC 3.4.21.39                Enzyme

Name

chymase;
mast cell protease I;
skeletal muscle protease;
skin chymotryptic proteinase;
mast cell serine proteinase;
skeletal muscle (SK) protease

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Preferential cleavage: Phe! > Tyr! > Trp! > Leu!

Comment

In mast cell granules. In peptidase family S1 (trypsin family)

History

EC 3.4.21.39 created 1981

Orthology

K01329

chymase

Genes

HSA:	1215(CMA1)

PTR:	745533(CMA1)

PPS:	100986161(CMA1)

GGO:	101131787(CMA1)

PON:	100432060(CMA1)

NLE:	100590719(CMA1)

HMH:	116485063(CMA1)

MCC:	716395(CMA1)

MCF:	102128612(CMA1)

MTHB:

126959477

MNI:	105477881(CMA1)

CSAB:

103228741(CMA1)

CATY:

105600218(CMA1)

PANU:

100999092

TGE:	112628993(CMA1)

MLEU:

105532747(CMA1)

RRO:	104662665(CMA1)

RBB:	108529495(CMA1)

TFN:	117069890(CMA1)

PTEH:

111552948(CMA1)

CANG:

105503706(CMA1)

CJC:	100388845(CMA1)

SBQ:	101040749(CMA1)

CIMI:

108297931(CMA1)

CSYR:

103273140(CMA1)

MMUR:

105866606 105866607

LCAT:

123650609(CMA1)

PCOQ:

105812753(CMA1)

OGA:	100952371(CMA1)

MMU:	17227(Mcpt4) 17228(Cma1)

MCAL:

110288188 110288847 110288848 110309191 110309194

MPAH:

110314663 110315169 110325079 110325080 110325354 110325355 110325569 110325712

RNO:	100360872(Mcpt1l1) 25627(Cma1)

MCOC:

116084365 116084422 116084454 116084761 116084762

ANU:	117705557 117705604 117705729 117705793 117705883 117706333

MUN:	110544703 110565884

CGE:	100756053 100767563

MAUA:

101842838 101843106

PROB:

127230512 127230514

PLEU:

114708716 114708743

MORG:

121435061 121435083 121435089

MFOT:

126492595 126492596 126492610

AAMP:

119800240 119800259 119800347

NGI:	103739405 103739493

HGL:	101714023 101714600(Cma1)

CPOC:

100135503(Cma1)

DORD:

105992492 105992493

DSP:	122113368 122113371

PLOP:

125345047 125345049 125345052 125345054

NCAR:

124977281 124977311

MMMA:

107145311 107145319

OCU:	100008644 100352190

OPI:	101529040(CMA1)

TUP:	102470931 102491108(CMA1)

GVR:	103584177 103590135 103590176

CFA:	490628(CMA1)

CLUD:

112657688(CMA1)

VVP:	112926474 112926566

VLG:	121492583 121493420

NPO:	129499396(CMA1) 129499466

AML:	100468421 100470691

UMR:	103679298 103679300

UAH:	113245992 113246021

UAR:	123795668(CMA1) 123795670

ELK:	111139042 111139669

LLV:	125104843 125105063

MPUF:

101670824(CMA1)

MNP:	131998757(CMA1)

MLK:	131836419(CMA1)

NVS:	122893097 122894514

ORO:	101371490 101371794

EJU:	114217787 114217856

ZCA:	113909271 113909731

MLX:	118003204 118003493

NSU:	110585334 110585496

LWW:	102748511 102751240(CMA1)

FCA:	101084796(CMA1)

PYU:	121031254 121031583

PCOO:

112855448 112855708

PBG:	122468961 122468962

PVIV:

125168543 125168545

LRUF:

124508202 124508873

PTG:	102957375 102967390(CMA1)

PPAD:

109254960(CMA1)

PUC:	125909628 125909629

AJU:

106987876

HHV:	120246989 120246992

BTA:	100139881 540321

BOM:	102281128 102282440

BIU:	109575276 109575291

BBUB:

112577709

BBIS:

104991006 104991060

CHX:	102171280 102174387 102183868 102188216 108635220 108638489

OAS:	101107261 101112678 114109029

BTAX:

128066767 128066773 128066820 128066859

ODA:	120875328 120875431

CCAD:

122419674 122419675 122454923

MBEZ:

129550077

SSC:

100156469

CFR:	102507358(CMA1)

CBAI:

105068855(CMA1)

VPC:

102529914

BACU:

103010490(CMA1)

BMUS:

118890525(CMA1)

LVE:	103078045(CMA1)

OOR:	125963385(CMA1)

DLE:	111164159(CMA1)

PCAD:

102984580(CMA1)

PSIU:

116749161

NASI:

112405044

ECB:

100050866

EPZ:	103561055(CMA1)

MYB:	102252573(CMA1) 102252869

MYD:	102760823(CMA1) 102774377

MMYO:

118678514(CMA1)

MLF:	102436406 102442410

PKL:	118726115(CMA1)

EFUS:

103301545(CMA1)

MNA:	107531684(CMA1)

DRO:	112300507 112300811

SHON:

118980905 118980906

AJM:	119037235 119037236

PDIC:

114492443 114492444

PHAS:

123820465 123820484

MMF:	118636167 118637047

HAI:	109393626 109393631

RFQ:

117023498

PALE:

102891376(CMA1)

PGIG:

120608539

PVP:	105309412(CMA1)

RAY:	107513520(CMA1)

MJV:	108392611 108392612

TOD:	119238079 119238080 119238973

SARA:

101538096(CMA1)

LAV:

100676374

TMU:

101353027

ETF:	101640954(CMA1)

DNM:	101423444 105744604

MDO:	100025555(CMA1)

GAS:	123236004(CMA1)

SHR:	100916327 100918953 100922955 105749239 111718797

AFZ:	127550638 127551108 127551109 127551110 127551112

PCW:	110206962(CMA1)

SRX:	107719607 107719608 107728555

SANH:

107655230 107687720

SGH:

107599477

CCAR:

109051449 109067161 109067176 109067177 109067178 109098001

MZE:

101464713

ONL:	100691973 109204554

OAU:

116327927

PSEX:

120536276

CSET:

123320251

API:

100162274

DNX:

107163889

» show all

Reference

1 [PMID:7043202]

Authors

Woodbury RG, Everitt MT, Neurath H.

Title

Mast cell proteases.

Journal

Methods Enzymol 80 Pt C:588-609 (1981)
DOI:10.1016/s0076-6879(81)80047-x

Reference

2 [PMID:3893542]

Authors

Powers JC, Tanaka T, Harper JW, Minematsu Y, Barker L, Lincoln D, Crumley KV, Fraki JE, Schechter NM, Lazarus GG, et al.

Title

Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.

Journal

Biochemistry 24:2048-58 (1985)
DOI:10.1021/bi00329a037

Reference

3 [PMID:2425663]

Authors

Johnson LA, Moon KE, Eisenberg M.

Title

Purification to homogeneity of the human skin chymotryptic proteinase "chymase".

Journal

Anal Biochem 155:358-64 (1986)
DOI:10.1016/0003-2697(86)90446-X

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