KEGG   ENZYME: 3.4.21.43
Entry
EC 3.4.21.43                Enzyme                                 
Name
classical-complement-pathway C3/C5 convertase;
C3 convertase;
C_overbar_42_;
C4b,2a;
C5 convertase;
C_overbar_423_;
C4b,2a,3b;
C42;
C423;
complement C.hivin.4.hivin2;
complement C3 convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg! bond in complement component C5 alpha-chain to form C5a and C5b
Comment
A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C_overbar_1s_. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC 3.4.21.44. Complement component C2a is in peptidase family S1 (trypsin family)
History
EC 3.4.21.43 created 1981 (EC 3.4.21.44 created 1981, incorporated 1984)
Orthology
K01332  complement component 2
Genes
HSA: 717(C2)
PTR: 100608992(C2)
PPS: 103783827(C2)
GGO: 101145799(C2)
PON: 100173033(C2)
NLE: 100606928(C2)
HMH: 116460294(C2)
MCC: 106997899(C2)
MCF: 102137096(C2)
MTHB: 126953216
MNI: 105497597(C2)
CSAB: 103221735(C2)
CATY: 105583240(C2)
TGE: 112622243(C2)
MLEU: 105554204(C2)
RRO: 104678122(C2)
RBB: 108520263(C2)
TFN: 117086977(C2)
CANG: 105513812(C2)
CJC: 103792363(C2)
SBQ: 104650316(C2)
CIMI: 108299811(C2)
CSYR: 103271297(C2)
MMUR: 105858160(C2)
LCAT: 123631761(C2)
PCOQ: 105817869(C2)
OGA: 100948920(C2)
MMU: 12263(C2)
MCAL: 110312387(C2)
MPAH: 110336126(C2)
RNO: 24231(C2)
MCOC: 116075350(C2)
ANU: 117724307(C2)
MUN: 110560138(C2)
CGE: 100759069(C2)
MAUA: 101829138(C2)
PLEU: 114705865(C2)
MORG: 121435235(C2)
MFOT: 126495378
AAMP: 119822469(C2)
NGI: 103724419(C2)
HGL: 101723809(C2)
CPOC: 100716184(C2)
CCAN: 109689592(C2)
DORD: 105999865(C2)
DSP: 122111495(C2)
PLOP: 125352766(C2)
NCAR: 124989526
MMMA: 107143589(C2)
OCU: 100355553 127488893
OPI: 101519169(C2)
TUP: 102480144(C2)
GVR: 103592349(C2)
CFA: 474853(C2)
CLUD: 112641335(C2)
VVP: 112913623(C2)
VLG: 121500782(C2)
NPO: 129512458(C2)
AML: 100474163(C2)
UMR: 103682287(C2)
UAH: 113243740(C2)
UAR: 123790974(C2)
ELK: 111152312
LLV: 125101523
MPUF: 101692540(C2)
MNP: 132017821(C2)
MLK: 131834325(C2)
NVS: 122911435(C2)
ORO: 101377842(C2)
EJU: 114222260(C2)
ZCA: 113927723(C2)
MLX: 118027318(C2)
NSU: 110586911(C2)
LWW: 102735390(C2)
FCA: 101092434(C2)
PYU: 121022335(C2)
PCOO: 112853511(C2)
PBG: 122478264(C2)
PVIV: 125166103(C2)
LRUF: 124528942
PTG: 102969252(C2)
PPAD: 109260505(C2)
PUC: 125938420
AJU: 106983482
HHV: 120221933(C2)
BTA: 515440(C2)
BOM: 102269155(C2)
BIU: 109576932(C2)
BBUB: 102406076(C2)
BBIS: 104983805(C2)
CHX: 102176085(C2)
OAS: 101115321(C2)
BTAX: 128056021(C2)
ODA: 120870574(C2)
CCAD: 122429826(C2)
MBEZ: 129543572(C2)
SSC: 448981(C2)
CFR: 102518989(C2)
CDK: 105087440(C2)
VPC: 102528144(C2)
BACU: 103018276(C2)
BMUS: 118903150(C2)
LVE: 103071578(C2)
OOR: 101281566(C2)
DLE: 111170704(C2)
PCAD: 102992128(C2)
PSIU: 116762860(C2)
NASI: 112395374(C2)
ECB: 100059162(C2)
EPZ: 103563291(C2)
EAI: 106831000(C2)
MYB: 102263362(C2)
MYD: 102766284(C2)
MMYO: 118679566(C2)
MLF: 102434614 102435622(C2)
EFUS: 103300457(C2)
MNA: 107538982(C2)
SHON: 118979560(C2)
AJM: 119053694(C2)
PDIC: 114494189(C2)
PHAS: 123810445(C2)
MMF: 118621434(C2)
PPAM: 129067328(C2)
RFQ: 117020467(C2)
PALE: 102889530(C2)
PGIG: 120618902(C2)
PVP: 105305295(C2)
RAY: 107498438(C2)
MJV: 108393991(C2)
TOD: 119252228(C2)
LAV: 100668309(C2)
TMU: 101350027
ETF: 101661223(C2)
MDO: 100025443(C2)
GAS: 123243666(C2)
SHR: 105750443(CFB)
AFZ: 127561087
PCW: 110199442(C2)
OAA: 100089242
GGA: 419574(C2)
PCOC: 116230112(C2)
MGP: 104914277
CJO: 107323905
TPAI: 128088525(C2)
LMUT: 125683968(C2)
NMEL: 110387356
ACHC: 115338421(CFB)
HLE: 104836577(C2)
ASN: 102381270(CFB)
AMJ: 102574290(C2)
CCAY: 125620990(C2)
CPIC: 101947880
CABI: 116829917
ACS: 100556178(c2)
PVT: 110088698(C2)
SUND: 121922133(C2)
PBI: 103049015
PMUR: 107295035
CTIG: 120309290
NSS: 113424960(C2)
ZVI: 118080127
GJA: 107105482
EMC: 129329017(C2)
XLA: 734198(c2.L)
XTR: 100491079(c2)
NPR: 108786508
RTEM: 120913253
BBUF: 120977489
BGAR: 122946772
MUO: 115458992 115466209(C2) 115474730
GSH: 117346944 117360271
DRE: 563828(si:ch1073-280e3.1)
SRX: 107720441
SANH: 107662575
SGH: 107567682
CCAR: 109055343
CAUA: 113115417
CGIB: 127972321(si:ch1073-280e3.1)
PTET: 122358886(si:ch1073-280e3.1)
LROH: 127177064(si:ch1073-280e3.1)
OMC: 131554417(si:ch1073-280e3.1)
PPRM: 120466881(si:ch1073-280e3.1)
RKG: 130097687(si:ch1073-280e3.1)
MAMB: 125248875(si:ch1073-280e3.1)
CIDE: 127495110(si:ch1073-280e3.1)
MASI: 127422257
TROS: 130565167(si:ch1073-280e3.1)
TDW: 130429106(si:ch1073-280e3.1)
MANU: 129437570(si:ch1073-280e3.1) 129437571
IPU: 100862743(si:ch1073-280e3.1)
IFU: 128621027(si:ch1073-280e3.1)
PHYP: 113539139
SMEO: 124394571(si:ch1073-280e3.1)
TFD: 113643603(si:ch1073-280e3.1)
TVC: 132857764(si:ch1073-280e3.1)
AMEX: 103046310
CMAO: 118802624(si:ch1073-280e3.1)
EEE: 113574701
CHAR: 105909325(si:ch1073-280e3.1)
TRU: 101064033
TFS: 130534764(si:ch1073-280e3.1)
TNG: GSTEN00026804G001
LCO: 104930441
NCC: 104962863
TBEN: 117469982(si:ch1073-280e3.1)
CGOB: 115017381
PGEO: 117457216(si:ch1073-280e3.1)
GACU: 117557378(si:ch1073-280e3.1)
EMAC: 134879681(si:ch1073-280e3.1)
ELY: 117259163(si:ch1073-280e3.1)
EFO: 125888711(si:ch1073-280e3.1)
PLEP: 121942912(si:ch1073-280e3.1)
SLUC: 116039027(si:ch1073-280e3.1)
ECRA: 117942570(si:ch1073-280e3.1)
ESP: 116685960
PFLV: 114549828
GAT: 120816446(si:ch1073-280e3.1)
PPUG: 119223014(si:ch1073-280e3.1)
AFB: 129102596(si:ch1073-280e3.1)
CLUM: 117741242(si:ch1073-280e3.1)
MSAM: 119882756(si:ch1073-280e3.1)
SCHU: 122878514(si:ch1073-280e3.1)
CUD: 121523692(si:ch1073-280e3.1)
ALAT: 119031698(si:ch1073-280e3.1)
MZE: 101480328
ONL: 100697699
OAU: 116323697(si:ch1073-280e3.1)
OLA: 101167637
OML: 112136450(si:ch1073-280e3.1)
CSAI: 133441555(si:ch1073-280e3.1)
XMA: 102229083
XCO: 114161640
XHE: 116737354
PRET: 103474842
PFOR: 103154630
PLAI: 106965101
PMEI: 106914174
GAF: 122832266(si:ch1073-280e3.1)
PPRL: 129358818(si:ch1073-280e3.1)
CVG: 107102499
CTUL: 119775419(si:ch1073-280e3.1)
GMU: 124883852(si:ch1073-280e3.1)
NFU: 107397014
KMR: 108244431(si:ch1073-280e3.1)
ALIM: 106530408
NWH: 119411148(si:ch1073-280e3.1)
AOCE: 111574507
MCEP: 125013111
POV: 109642964
SSEN: 122772936(si:ch1073-280e3.1)
HHIP: 117772604(si:ch1073-280e3.1)
HSP: 118106051(si:ch1073-280e3.1)
SMAU: 118295617(si:ch1073-280e3.1)
LCF: 108890635(si:ch1073-280e3.1)
XGL: 120792530(si:ch1073-280e3.1)
BPEC: 110162865
BSPL: 114867603(si:ch1073-280e3.1)
SJO: 128360481(si:ch1073-280e3.1)
SASA: 106580826
STRU: 115163141
OTW: 112265208(si:ch1073-280e3.1)
OMY: 100135805(si:ch1073-280e3.1)
OGO: 123992917(si:ch1073-280e3.1)
ONE: 115136963
OKI: 109905531
OKE: 118397273(si:ch1073-280e3.1)
SALP: 111982534
SNH: 120018329(si:ch1073-280e3.1)
CCLU: 121563694(si:ch1073-280e3.1)
ELS: 105011227
SFM: 108928780
PKI: 111854971
AANG: 118209021(si:ch1073-280e3.1)
LOC: 102694189 107079953
PSPA: 121304122
ARUT: 117433872(si:ch1073-280e3.1) 117971245
PSEX: 120539046(si:ch1073-280e3.1)
BFO: 118420754
CIN: 497243(bf-1) 619241(bf-2)
SPU: 754422 756500 756883
LPIC: 129277947 129277948
APLC: 110983861
SKO: 100368814
PTEP: 107450490
DPOL: 127837341
LAK: 106177660 106178727
NVE: 5501707 5502106 5515331
EPA: 110235255 110235277 110235590 110242877 110244509 110253640
ATEN: 116298611 116308431 116308433
ADF: 107349284 107355215
AMIL: 114946777 114954057 114977272
PDAM: 113668202 113675686
SPIS: 111328750 111343603 111345231
 » show all
Reference
1
  Authors
Kerr, M.A.
  Title
The second component of human complement.
  Journal
Method Enzymol 80:54-64 (1981)
Reference
2  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.43
IUBMB Enzyme Nomenclature: 3.4.21.43
ExPASy - ENZYME nomenclature database: 3.4.21.43
BRENDA, the Enzyme Database: 3.4.21.43
CAS: 56626-15-4

  All links  
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (321)   
   KEGG MGENES (55)   
   RefGene (16)   
Protein sequence (481)   
   UniProt (445)   
   SWISS-PROT (6)   
   RefSeq(pep) (23)   
   PDBSTR (6)   
   PMD (1)   
DNA sequence (54)   
   RefSeq(nuc) (28)   
   GenBank (17)   
   EMBL (9)   
3D Structure (6)   
   PDB (6)   
Protein domain (11)   
   InterPro (11)   
All databases (945)   

Download RDF
DBGET integrated database retrieval system