KEGG ENZYME: 3.4.21.46

ENZYME: 3.4.21.46

Entry

EC 3.4.21.46                Enzyme

Name

complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor

Comment

A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)

History

EC 3.4.21.46 created 1981

Orthology

K01334

complement factor D

Genes

HSA:

1675(CFD)

PON:	100936423(CFD)

NLE:	100599422(CFD)

HMH:	116482906(CFD)

MCC:	721138(CFD)

MCF:	102136571(CFD)

MTHB:

126942983

MNI:	105486424(CFD)

CSAB:

103233571(CFD)

CATY:

105591689(CFD)

TGE:	112612318(CFD)

RRO:	104671463(CFD)

TFN:	117075456(CFD)

PTEH:

111534786(CFD)

CANG:

105527672(CFD)

CJC:	100389630(CFD)

SBQ:	101030841(CFD)

CIMI:

108293137(CFD)

MMUR:

105860755(CFD)

LCAT:

123632771(CFD)

PCOQ:

105811278(CFD)

OGA:	100960466(CFD)

MMU:	11537(Cfd)

MCAL:

110303909(Cfd)

MPAH:

110326960(Cfd)

RNO:	54249(Cfd)

MCOC:

116076101(Cfd)

ANU:	117696367(Cfd)

MUN:	110551364(Cfd)

CGE:	100763302(Cfd)

MAUA:

121136815(Cfd)

PROB:

127216809(Cfd)

PLEU:

114684101(Cfd)

MORG:

121459661(Cfd)

MFOT:

126489244

AAMP:

119802884(Cfd)

NGI:	103737401(Cfd)

HGL:	106007830(Cfd)

CPOC:

100724693(Cfd)

CCAN:

109693669(Cfd)

DSP:	122122752(Cfd)

PLOP:

125348532(Cfd)

NCAR:

124968607

MMMA:

107157231(Cfd)

OPI:

101525706

TUP:	106734227(CFD)

GVR:	103607668(CFD)

CFA:	485095(CFD)

CLUD:

112666161(CFD)

VVP:	112935509(CFD)

VLG:	121494247(CFD)

NPO:	129521678(CFD)

AML:	100483447(CFD) 117800215

UMR:	103681627(CFD)

UAH:	113242706(CFD)

UAR:	123794054(CFD)

ELK:

111161686

LLV:

125087404

MPUF:

101678869(CFD)

MNP:	132009635(CFD)

MLK:	131823166(CFD)

NVS:

122910832

ORO:	101380360(CFD)

EJU:	114226342(CFD)

ZCA:	113917886(CFD)

MLX:	118005033(CFD)

NSU:	110593928(CFD)

LWW:	102729662(CFD)

FCA:	101093500(CFD)

PYU:	121021311(CFD)

PBG:	122486624(CFD)

PVIV:

125159749(CFD)

LRUF:

124527664

PPAD:

109257710(CFD)

PUC:

125931055

AJU:

113596379

HHV:	120242412(CFD)

BTA:	505647(CFD)

BOM:	102275200(CFD)

BBUB:

102411586(CFD)

BBIS:

104991904(CFD)

CHX:	102173560(CFD)

OAS:	101115705(CFD)

BTAX:

128051780(CFD)

ODA:	120863726(CFD)

MBEZ:

129558753(CFD)

SSC:	396877(CFD)

CFR:	102507253(CFD)

CBAI:

105078119(CFD)

CDK:	105106574(CFD)

VPC:	102525040(CFD)

BMUS:

118892700(CFD)

LVE:	103086658(CFD)

OOR:	101272668(CFD)

DLE:	111170499(CFD)

PCAD:

102995550(CFD)

PSIU:

116750930(CFD)

NASI:

112396384(CFD)

ECB:	111774154(CFD)

EAI:	106834238(CFD)

MYD:	102756294(CFD)

MMYO:

118659139(CFD)

MLF:	102427276(CFD)

PKL:	118711775(CFD)

EFUS:

103294435(CFD)

MNA:	107538545(CFD)

SHON:

118984388(CFD)

AJM:	119044597(CFD)

MMF:	118615470(CFD)

PPAM:

129080091(CFD)

HAI:	109390585(CFD)

RFQ:	117038399(CFD)

PALE:

102897797(CFD)

PGIG:

120583677(CFD)

RAY:	107500957(CFD)

MJV:	108395527(CFD)

TOD:	119240492(CFD)

SARA:

101553713(CFD)

LAV:	100672291(CFD)

TMU:

101356637

ETF:	101643268(CFD)

GAS:

123254000

SHR:	100928352(CFD)

AFZ:

127545085

PCW:	110196242(CFD)

OAA:	791100(CFD)

GGA:	100857593(CFD)

PCOC:

116235815(CFD)

MGP:	100541228(CFD)

CJO:	107325464(CFD)

TPAI:

128090391

LMUT:

125684830

NMEL:

110388819(CFD)

APLA:

113845674(CFD)

ACYG:

106049106(CFD)

CATA:

118260040

AFUL:

116499209(CFD)

TGU:

100224290

LSR:

110475732

SCAN:

103822039

PMOA:

120513444

OTC:

121341721

PRUF:

121361872(CFD)

GFR:	102036496(CFD)

FAB:	101807799(CFD)

OMA:

130264627

PHI:

102114080

PMAJ:

107215597

CCAE:

111940403

CCW:	104697052(CFD)

CBRC:

103622133(CFD)

ETL:	114066373(CFD)

ZAB:	102069032(CFD)

ACHL:

103809276(CFD)

SVG:

106857090

MMEA:

130580229

HRT:

120763398

FPG:	101921526(CFD)

FCH:	102048162(CFD)

CLV:	106145861(CFD)

NNI:	104016308(CFD)

TALA:

116961660(CFD)

AFOR:

103899332(CFD)

ACHC:

115349111(CFD)

HLE:

104829159

AGEN:

126041763

GCL:

127025468

SHAB:

115618015(CFD)

CPEA:

104392452(CFD)

CUCA:

104067745(CFD)

AAM:	106484250(CFD)

AROW:

112965646(CFD)

NPD:

112946823

DNE:	112988069(CFD)

ASN:

102381206

AMJ:	102567707(CFD)

CPOO:

109312290(CFD)

GGN:

109294926

PSS:

112545587

CMY:	102931053 114022442

CCAY:

125627053 125627055

CPIC:

101935732

TST:

117868803

CABI:

116827447 116827718

MRV:

120391700

ASAO:

132781010(CFD)

PVT:	110072602(CFD)

SUND:

121916385 121918355

PBI:

103066225

PMUR:

107282291(CFD)

CTIG:

120304317

TSR:

106542872

PGUT:

117677459(CFD)

APRI:

131192662

PTEX:

113435229

NSS:

113414098

VKO:	123035384(CFD)

PMUA:

114588305(CFD)

PRAF:

128405921(CFD)

ZVI:	118086494(CFD)

HCG:	128346388(CFD)

GJA:	107120759(CFD)

STOW:

125433984(CFD)

EMC:	129329701(CFD)

XLA:	494791(cfd.L)

XTR:	394945(cfd)

NPR:

108798700

RTEM:

120910362

BBUF:

120989435

BGAR:

122930786

MUO:

115479507

GSH:

117364559

DRE:	553553(cfd)

SRX:

107733667

SANH:

107666376 107695014

SGH:

107556907

CCAR:

109071492 109071498

CAUA:

113057061 113112848

CGIB:

127970787 128026367

PTET:

122356094(cfd)

LROH:

127175438(cfd)

OMC:	131551728(cfd)

PPRM:

120479299(cfd)

RKG:	130083046(cfd)

MAMB:

125276571(cfd)

CIDE:

127525436

MASI:

127411881 127414265

TROS:

130559206(cfd)

TDW:	130431820 130431823

MANU:

129416029(cfd)

IPU:	100862744(cfd)

IFU:	128605484(cfd)

PHYP:

113544922

SMEO:

124401299(cfd)

TFD:	113639975(cfd)

TVC:	132847189(cfd)

AMEX:

103044529

CMAO:

118810289(cfd)

EEE:

113579255

CHAR:

105909594(cfd)

TRU:

101070023

TFS:	130539797(cfd)

TNG:	GSTEN00012908G001

LCO:

104926791

NCC:

104963116

TBEN:

117491231(cfd)

CGOB:

115027348

PGEO:

117468135(cfd)

GACU:

117558840(cfd)

EMAC:

134882007(cfd)

ELY:	117266675(cfd)

EFO:	125900873(cfd)

PLEP:

121954070(cfd)

SLUC:

116036785(cfd)

ECRA:

117936166(cfd)

ESP:

116686939

PFLV:

114547394

GAT:	120832694(cfd)

PPUG:

119227597(cfd)

AFB:	129103067(cfd)

CLUM:

117725493(cfd)

PSWI:

130201208(cfd)

MSAM:

119910420(cfd)

SCHU:

122862283(cfd)

CUD:	121526046(cfd)

ALAT:

119005139(cfd)

MZE:

101478226

ONL:

100692083

OAU:	116329030(cfd)

OLA:	100049308(olklklp)

OML:	112150046(cfd)

CSAI:

133462271(cfd)

XMA:

102225583

XCO:

114134801

XHE:

116709474

PRET:

103458165

GAF:	122846140(cfd)

PPRL:

129377430(cfd)

CVG:

107087104

CTUL:

119796215(cfd)

GMU:	124885048(cfd)

NFU:

107373416

KMR:	108250570(cfd)

ALIM:

106519943

NWH:	119427911(cfd)

AOCE:

111580112

MCEP:

125024194(cfd)

CSEM:

103383188

POV:

109640960

SSEN:

122782500(cfd)

HHIP:

117756454(cfd)

HSP:	118115936(cfd)

SMAU:

118285663(cfd)

LCF:	108889155(cfd)

SDU:

111225539

SLAL:

111646789

XGL:	120795014(cfd)

HCQ:

109511554

SSCV:

125980650

SBIA:

133513822(cfd)

PEE:	133413086(cfd)

PTAO:

133487456(cfd)

BPEC:

110155605

MALB:

109962455

BSPL:

114848564(cfd)

SJO:	128375215(cfd)

SASA:

101448046

STRU:

115173057

OTW:	112265777(cfd)

OMY:	110514148(cfd)

OGO:	124025771 124029184

ONE:

115126409

OKI:

109885073

OKE:	118383623 127917973

SALP:

112075441

SNH:	120042389(cfd)

CCLU:

121556229(cfd) 121556989

ELS:

105015868

SFM:

108919827

PKI:

111860508

AANG:

118224646(cfd)

LOC:

102685416

PSPA:

121300830 121301136 121301521

ARUT:

117428810 117428860 117428987 117428988 117966210 117966232 117966331

AMER:

121599767

AFUN:

125767070

BCOO:

119070104

FAS:

105267006

BANY:

112055271

SLIU:

111349872

CLEC:

106662046

HHAL:

106689898

MQU:	128989520 128989809

DMK:	116925602 116925603 116925605 116925681 116931363 116934608

PJA:

122244116

» show all

Reference

1 [PMID:6918766]

Authors

Reid KB, Johnson DM, Gagnon J, Phohaska R.

Title

Preparation of human factor D of the alternative pathway of complement.

Journal

Methods Enzymol 80 Pt C:134-43 (1981)
DOI:10.1016/s0076-6879(81)80013-4

Reference

2 [PMID:3052276]

Authors

Muller-Eberhard HJ.

Title

Molecular organization and function of the complement system.

Journal

Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.46

IUBMB Enzyme Nomenclature:

3.4.21.46

ExPASy - ENZYME nomenclature database:

3.4.21.46

BRENDA, the Enzyme Database:

3.4.21.46

CAS:	37213-56-2

DBGET integrated database retrieval system