KEGG ENZYME: 3.4.21.47

ENZYME: 3.4.21.47

Entry

EC 3.4.21.47                Enzyme

Name

alternative-complement-pathway C3/C5 convertase;
complement component C3/C5 convertase (alternative);
proenzyme factor B;
properdin factor B;
C3 proactivator;
glycine-rich beta-glycoprotein;
heat-labile factor;
C3 convertase;
C3b,Bb,CVF,Bb,C5 convertase;
(C3b)n,Bb;
complement C 3(C 5) convertase (amplification);
alternative complement pathway C3(C5) convertase;
C5 convertase;
CVF,Bb;
(CVF)-dependent glycine-rich-beta-glucoprotein;
cobra venom factor-dependent C3 convertase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Cleavage of Arg!Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg! bond in complement component C5 alpha-chain to yield C5a and C5b

Comment

A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family)

History

EC 3.4.21.47 created 1981

Orthology

K01335

complement factor B

Genes

HSA:

629(CFB)

PTR:	494140(CFB)

PPS:	100990821(CFB)

GGO:	101141641(CFB)

PON:	103890868(CFB)

NLE:	100595765(CFB)

HMH:	116460293(CFB)

MCC:	716809(CFB)

MCF:	102133787(CFB)

MTHB:

126953215

MNI:	105497598(CFB)

CSAB:

108449896(CFB)

CATY:

105583239(CFB)

TGE:	112622244(CFB)

MLEU:

105554196(CFB)

RRO:	104678121(CFB)

RBB:	108520262(CFB)

TFN:	117086976(CFB)

PTEH:

111523926

CANG:

105513764(CFB)

CJC:	100409227(CFB)

SBQ:	101036079(CFB)

CIMI:

108299810(CFB)

CSYR:

103271298(CFB)

MMUR:

105858159(CFB)

LCAT:

123631760(CFB)

PCOQ:

105817868(CFB)

OGA:	100949772(CFB)

MMU:	14962(Cfb)

MCAL:

110312388(Cfb)

MPAH:

110336125(Cfb)

RNO:	294257(Cfb)

MCOC:

116075349(Cfb)

ANU:	117724306(Cfb)

MUN:	110560137(Cfb)

CGE:	100758781(Cfb)

MAUA:

101829676(Cfb)

PROB:

127224317

PLEU:

114705866(Cfb)

MORG:

121435234(Cfb)

MFOT:

126495379

AAMP:

119822468(Cfb)

NGI:	108490121(Cfb)

HGL:	101725137(Cfb)

CPOC:

100715616(Cfb)

CCAN:

109689576(Cfb)

DORD:

105999873(Cfb)

DSP:	122111494(Cfb)

PLOP:

125352765(Cfb)

NCAR:

124989525

MMMA:

107143742(Cfb)

OCU:	100355944 127493062

OPI:	101536636(CFB)

TUP:	102480574(CFB)

GVR:	103592350(CFB)

CFA:	100688056(CFB)

CLUD:

112641336(CFB)

VVP:	112913626(CFB)

VLG:	121500776(CFB)

NPO:	129513062(CFB)

AML:	100474759(CFB)

UMR:	103682288(CFB)

UAH:	113243739(CFB)

UAR:	123790973(CFB)

ELK:

111152198

LLV:

125101522

MPUF:

101692539(CFB)

MNP:	132017820(CFB)

MLK:	131834324(CFB)

NVS:	122911427(CFB)

ORO:	101378817(CFB)

EJU:	114222131(CFB)

ZCA:	113927725(CFB)

MLX:	118027314(CFB)

NSU:	110586797(CFB)

LWW:	102736578(CFB)

FCA:	101093018(CFB)

PYU:	121022337(CFB)

PCOO:

112853528(CFB)

PBG:	122478265(CFB)

PVIV:

125166111(CFB)

LRUF:

124528856

PTG:	102969938(CFB)

PPAD:

109260506(CFB)

PUC:

125938421

AJU:

106983483

HHV:	120221920(CFB)

BTA:	514076(CFB)

BOM:	102267775(CFB)

BIU:	109576933(CFB)

BBUB:

102404663(CFB)

BBIS:

104983806(CFB)

CHX:	102175816(CFB)

OAS:	101115072(CFB)

BTAX:

128055296(CFB)

ODA:	120870573(CFB)

CCAD:

122429827(CFB)

MBEZ:

129543123(CFB)

SSC:	100124383(CFB)

CFR:	102519366(CFB)

CBAI:

105074040

CDK:	105087438(CFB)

VPC:	102528827(CFB)

BACU:

103017988(CFB)

BMUS:

118903152(CFB)

LVE:	103071310(CFB)

OOR:	101281312(CFB)

DLE:	111170703(CFB)

PCAD:

102991673(CFB)

PSIU:

116762859(CFB)

NASI:

112395373(CFB)

ECB:	100051124(CFB)

EPZ:	103563301(CFB)

EAI:	106831003(CFB)

MYB:	102262757(CFB)

MYD:	102766003(CFB)

MMYO:

118679565(CFB)

MLF:	102435318(CFB)

PKL:	118705365(CFB)

EFUS:

103300456(CFB)

MNA:	107538978(CFB)

DRO:

112302049

SHON:

118979559(CFB)

AJM:	119053693(CFB)

PDIC:

114494197(CFB)

PHAS:

123810444(CFB)

MMF:	118621310(CFB)

PPAM:

129067330(CFB)

HAI:	109373064(CFB)

RFQ:	117020466(CFB)

PALE:

102877940(CFB)

PGIG:

120618897(CFB)

PVP:	105305289(CFB)

RAY:	107498437(CFB)

MJV:	108393990(CFB)

TOD:	119252230(CFB)

SARA:

101542103

SETR:

125996204(CFB)

LAV:	100668025(CFB)

TMU:

101350698

ETF:	101661853(CFB)

DNM:

101435826

MDO:	107648882(CFB)

GAS:	123245151(CFB)

AFZ:

127561088

PCW:	110199443(CFB)

LMUT:

125686229

PHI:	106628820(CFB)

MMEA:

130587546

AMJ:	102574048(CFB) 109280870

CCAY:

125620991(CFB) 125638670

DCC:	119842618(CFB)

CPIC:

101943785 101945361

MRV:

120403300

ACS:	100555786 100555981(cfb)

ASAO:

132765242

PVT:	110088690(CFB)

SUND:

121922134

PBI:

103054626

PMUR:

107287873 107300231 107302884

CTIG:

120309287 120309288

TSR:	106539402 106544271

PGUT:

117667853

APRI:

131193051

PTEX:

113449071 113452771

NSS:	113424958(CFB)

PMUA:

114590977(CFB)

HCG:	128343946(CFB)

GJA:	107105481(CFB)

EMC:	129329016(CFB)

XLA:	108698939 373577(cfb.S) 397725(cfb.L)

XTR:	100491419(cfb)

NPR:

108786506

RTEM:

120913256

BBUF:

120977484 120977492 120977496 120978194 120978195 120978196

BGAR:

122919722 122946120 122946787 122946788 122946789

MUO:	115466210(CFB)

GSH:	117346945(CFB)

DRE:	30604(cfb) 792472(cfbl)

SRX:	107715263 107715390 107715393 107723846 107756066 107756181

SANH:

107669352 107669354 107693811 107693822

SGH:	107568309 107572119 107574087 107574090

CCAR:

109052426 109052431

CAUA:

113038495 113038496 113063652 113064084 113064085 113064160 113071732 113078027

CGIB:

127941543 127941544 127941545 127986601 127986602

PTET:

122326861 122326862 122326863

LROH:

127152807 127152808 127162231

OMC:	131528199 131528201 131528455 131528456

PPRM:

120494436(cfb) 120494437

RKG:	130095288 130095290(cfbl) 130095291

MAMB:

125252216 125252217 125252218 125252219 125252222(cfbl)

CIDE:

127503140 127503142

MASI:

127428639 127430541 127430554

TDW:	130407559 130407560 130407561

MANU:

129423416 129423417 129423419 129423420

IPU:

100862742

IFU:

128622558

PHYP:

113541515 113541657

SMEO:

124397805 124398258

TFD:	113662099 113662100

TVC:

132859841

AMEX:

103039688 103040831

CMAO:

118802480 118819931 118819932(cfbl)

EEE:	113568769 113585998

CHAR:

105904728 105909372 105909521

TRU:	101069540 101069998

TFS:	130537476 130537477

TNG:	GSTEN00018968G001

LCO:

104929932

NCC:

104964654

TBEN:

117490327 117490328

CGOB:

115018874 115018985

PGEO:

117458722

GACU:

117535515

EMAC:

134872532

ELY:

117272009

EFO:

125898344

PLEP:

121952156

SLUC:

116064868

ECRA:

117955159

ESP:

116700002

PFLV:

114566514

GAT:

120821357

PPUG:

119215742

AFB:

129113155

CLUM:

117742524

PSWI:

130189422(cfb)

MSAM:

119895101

SCHU:

122888645

CUD:

121518408

ALAT:

119031420 119031421

MZE:

101486732

ONL:

100707990

OAU:	116317731 116336174

OLA:	100049430(bf/c2)

OML:	112142732 112142733

CSAI:

133459640(cfbl)

XMA:	102216506 102235456

XCO:

114153817

XHE:

116727817

PRET:

103475468

PFOR:

103141081

PLAI:

106956137

PMEI:

106921330

GAF:	122844416 122844417

PPRL:

129368830

CVG:	107098502 107098503

CTUL:

119775850(bfb) 119775881

GMU:	124876043 124876048

NFU:	107379288 107379289 107386372

KMR:

108237014

ALIM:

106514073

NWH:

119420895

AOCE:

111580649

MCEP:

125021287

CSEM:

103395154

POV:

109628349

SSEN:

122779130

HHIP:

117774178

HSP:

118122675

SMAU:

118301188

LCF:

108893578

SDU:

111234364

SLAL:

111666299

XGL:

120802806

HCQ:

109517895

SSCV:

125982648

SBIA:

133491951

PEE:

133415849

PTAO:

133467488

BPEC:

110158573

MALB:

109959265

BSPL:

114869783 114869784 114869785

SJO:	128370997 128371817

SASA:

106563698 106569366 106602980

STRU:

115154834 115157306 115204449

OTW:	112228943 112231175(cfbl) 112260753

OMY:	100136605(cfbl) 100653464 110534129(cfb)

OGO:	124006256 124007468 124010056

ONE:	115101442 115114668 115135507

OKI:	109872818 109873985 109875216

OKE:	118384990(cfbl) 118390500 118401882

SALP:

111956628 111964346

SNH:	120021442(cfbl) 120056081 120057316

CCLU:

121542096 121579609 123481564

ELS:	105030044 105030049

SFM:	108934440(cfb) 108938433

PKI:	111839196 111860092

AANG:

118234983(cfbl)

PSPA:

121299068(cfbl)

ARUT:

117398282 117430318 117434000 117434001 117964868 117964901 117964906

LCM:	102360252 102360987(CFB)

RTP:

109921430

CPLA:

122541420 122541423 122564127

HOC:	132832720 132832721

LERI:

129710735 129716249

PMRN:

116942790 116946924

LRJ:	133342838 133351216

BBEL:

109471260

CIN:	497244(bf-3)

SCLV:

120329807 120344514 120344863 120344889 120345032 120345064

SPU:	373308(bf)

APLC:

110989106 110989117

SKO:

100373330

RSAN:

119395859

RMP:

119173521

CSCU:

111622536 111622553

PTEP:

107454561

ABRU:

129965689 129968838

UDV:	129224726 129234609

SDM:	118189532 118204855

LPOL:

106464946

MMER:

123548952 123552382

RPHI:

132723260 132731317 132741992

ATEN:

116300929

PDAM:

113673827

SPIS:

111333045

DGT:	114533679 114533680

XEN:	124438971 124439145

» show all

Reference

1 [PMID:7043188]

Authors

Kerr MA.

Title

Human factor B.

Journal

Methods Enzymol 80 Pt C:102-12 (1981)
DOI:10.1016/s0076-6879(81)80010-9

Reference

2 [PMID:6323161]

Authors

Morley BJ, Campbell RD.

Title

Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.

Journal

EMBO J 3:153-7 (1984)
DOI:10.1002/j.1460-2075.1984.tb01776.x

Sequence

[hsa:629]

Reference

3 [PMID:3052276]

Authors

Muller-Eberhard HJ.

Title

Molecular organization and function of the complement system.

Journal

Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.47

IUBMB Enzyme Nomenclature:

3.4.21.47

ExPASy - ENZYME nomenclature database:

3.4.21.47

BRENDA, the Enzyme Database:

3.4.21.47

CAS:	80295-67-6

DBGET integrated database retrieval system