KEGG ENZYME: 3.4.21.59

ENZYME: 3.4.21.59

Entry

EC 3.4.21.59                Enzyme

Name

tryptase;
mast cell tryptase;
mast cell protease II;
skin tryptase;
lung tryptase;
pituitary tryptase;
mast cell neutral proteinase;
mast cell serine proteinase II;
mast cell proteinase II;
mast cell serine proteinase tryptase;
rat mast cell protease II;
tryptase M

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Preferential cleavage: Arg!, Lys!, but with more restricted specificity than trypsin

Comment

Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin

History

EC 3.4.21.59 created 1992

Orthology

K01340

tryptase

Genes

HSA:	23430(TPSD1) 64499(TPSB2) 7177(TPSAB1)

PTR:	100614054 454333(TPSB2) 468084

PPS:	100978423(TPSB2) 100983216 100983474 117978660 117978661(TPSD1)

GGO:	101141984 101143084

PON:	100294628 100448573(TPSD1)

NLE:

100586612

HMH:

116462355

MCC:	100425930 699599

MCF:	102139613 102140229

MTHB:

126944863 126944864

MNI:	105485867 105485868

CSAB:

103225829 103225859

CATY:

105574008 105574098

PANU:

101010225 110741984

TGE:	112613876 112613877

MLEU:

105529714 105529715

RRO:	104681498 104681499

TFN:	117097868 117097870

PTEH:

111535552

CANG:

105526440

CJC:

128929226

SBQ:

101042059

CIMI:

108290820 108290897

CSYR:

103254059 103255338

MMUR:

105859603(TPSAB1) 105859609

LCAT:

123631366 123631437

PCOQ:

105813025

OGA:	100947777 100948098

MMU:	100503895(Tpsab1) 17229(Tpsb2)

MCAL:

110284076 110284206

MPAH:

110338270 110338502

RNO:	29268(Tpsb2) 54271(Tpsab1)

MCOC:

116077537 116077731

ANU:	117711500 117711548

MUN:

110548711

CGE:

118239120

MAUA:

101833448

PLEU:

114681232 114681248

NGI:	103752457(Tpsb2)

HGL:

101712997

CCAN:

109690196

DORD:

105981925

DSP:

122123737

PLOP:

125340749

MMMA:

107147134 107147136

GVR:

103588767

CFA:

100049001

CLUD:

112640591

VVP:

112909106

VLG:

121487580

NPO:

129519912

AML:

100477216

UMR:

103668756

UAH:

113245122

UAR:

123783776

ELK:

111156014

LLV:

125090219

MPUF:

106005611

MNP:

132027064

MLK:

131819434

NVS:

122896091

ORO:

101378934

EJU:

114215748

ZCA:

113933006

MLX:

118021920

NSU:

110588010

LWW:

102735356

HHV:

120241568

BTA:	281545(TPSB2) 786948

BOM:

102276593

BIU:	109578813 109578824

BBUB:

102415161 112581768

BBIS:

104988253

CHX:	102177855 102178129

OAS:	100144429 443433(TPSB2)

BTAX:

128043493 128043495

ODA:	120859362 120859384 120882273

CCAD:

122432925 122433089

MBEZ:

129545062

SSC:	110255206 397389(MCT7)

CBAI:

105062365 105064891 105064937

VPC:	102531374 116278558 116284114

BMUS:

118881280

OOR:

101285596

DLE:	111184995 111184996

PSIU:

116740244 116740299

NASI:

112392046

ECB:	100033966(RET)

EPZ:

103542236

EAI:	106836196(TPSB2)

MYB:	102258623(TPSB2) 102258917(TPSAB1)

MYD:

102774334

MMYO:

118652902 118652903

MLF:	102419094 102419400 102437182

PKL:	118731552 118731553 118731556

EFUS:

103300807 103304644 103304969

MNA:	107533340 107533342

DRO:	112298273 112298274

SHON:

118978859

AJM:	119058218 119058238(TPSB2)

PDIC:

114503298 114508660

PHAS:

123825553 123825586

MMF:

118641912

PPAM:

129083354 129083356

RFQ:	117019668 117019883 117019884

PALE:

102890577(TPSB2)

PGIG:

120620210 120620543

PVP:

105303290

RAY:	107506027 107506028

SARA:

101547756

ETF:	101653980 105978903 105978904

DNM:

101428717

MDO:

100022090

GAS:	123230922 123248737 123256465 123256483

SHR:

100920443

AFZ:	127543366 127543367

OAA:

100087741

LOC:

102685043

AFUN:

125769303

DSM:

124416410

SOY:

115881038

AGRG:

126734666

MQU:

128983513

DMK:

116920722

DSV:

119461781

CVN:	111126160 111126199 111127432 111127433

MMER:

123533887 123535369

DPOL:

127831431 127856400 127858045 127866634 127866635 127872684

APUU:

APUU_31283S

» show all

Reference

1 [PMID:6358206]

Authors

Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC.

Title

Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.

Journal

J Biol Chem 258:13552-7 (1983)

Reference

2 [PMID:3890754]

Authors

Kido H, Fukusen N, Katunuma N.

Title

Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions.

Journal

Arch Biochem Biophys 239:436-43 (1985)
DOI:10.1016/0003-9861(85)90709-X

Reference

3 [PMID:3543004]

Authors

Cromlish JA, Seidah NG, Marcinkiewicz M, Hamelin J, Johnson DA, Chretien M.

Title

Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

Journal

J Biol Chem 262:1363-73 (1987)

Sequence

[hsa:7177]

Reference

4 [PMID:3140898]

Authors

Harvima IT, Schechter NM, Harvima RJ, Fraki JE.

Title

Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.

Journal

Biochim Biophys Acta 957:71-80 (1988)
DOI:10.1016/0167-4838(88)90158-6