KEGG ENZYME: 3.4.21.61

ENZYME: 3.4.21.61

Entry

EC 3.4.21.61                Enzyme

Name

kexin;
yeast KEX2 protease;
proteinase yscF (gene name);
prohormone-processing endoprotease;
paired-basic endopeptidase;
yeast cysteine proteinase F (misleading);
andrenorphin-Gly-generating enzyme;
endoproteinase Kex2p;
gene KEX2 dibasic proteinase;
Kex 2p proteinase;
Kex2 endopeptidase;
Kex2 endoprotease;
Kex2 endoproteinase;
Kex2 protease;
proteinase Kex2p;
Kex2-like precursor protein processing endoprotease;
prohormone-processing KEX2 proteinase;
prohormone-processing proteinase;
proprotein convertase;
protease KEX2;
Kex2 proteinase;
Kex2-like endoproteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors

Comment

A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.

History

EC 3.4.21.61 created 1989 as EC 3.4.22.23, transferred 1992 to EC 3.4.21.61

Orthology

K01341

kexin

Genes

SCE:	YNL238W(KEX2)

SEUB:

DI49_4509

SPAO:

SPAR_N00900

AGO:	AGOS_ABL203W

ERC:

Ecym_6486

KLA:	KLLA0_D19811g

KMX:	KLMA_50628(KEX1)

LTH:	KLTH0H00418g

VPO:	Kpol_1015p8

ZRO:	ZYRO0F15598g

CGR:	CAGL0J07546g

NCS:	NCAS_0A00880(NCAS0A00880)

NDI:	NDAI_0F03890(NDAI0F03890)

TPF:	TPHA_0P01790(TPHA0P01790)

TBL:	TBLA_0B00130(TBLA0B00130)

TGB:	HG536_0D00240

TDL:	TDEL_0E00410(TDEL0E00410)

KAF:	KAFR_0A08040(KAFR0A08040)

KNG:	KNAG_0F00770(KNAG0F00770)

ZMK:	HG535_0D00290

PPA:	PAS_chr2-1_0304

DHA:	DEHA2C10296g

PIC:	PICST_14973

PGU:	PGUG_03723

SPAA:

SPAPADRAFT_139715 SPAPADRAFT_153129 SPAPADRAFT_50884

LEL:	PVL30_000307(KEX2)

CAL:	CAALFM_C108990CA(KEX2)

CTP:	CTRG_03249

COT:	CORT_0A01670

CDU:	CD36_08480

CTEN:

CANTEDRAFT_124869

YLI:	YALI0F13189g

CLU:	CLUG_01869

CLUS:

A9F13_02g04334

CAUR:

CJI96_0004601

SLB:	AWJ20_2368(KEX2)

PKZ:	C5L36_0E01280

BNN:	FOA43_004608

BBRX:

BRETT_001804

OPA:	HPODL_03866

SLUD:

SCDLUD_003039

NCR:

NCU03219

NTE:	NEUTE1DRAFT133220(NEUTE1DRAFT_133220)

SMP:	SMAC_02938

PAN:	PODANSg09433

PBEL:

QC761_101930(KEX2)

PPSD:

QC762_101930(KEX2)

PPSP:

QC763_101930(KEX2)

PPSA:

QC764_101930(KEX2)

TTT:	THITE_2120746

MTM:	MYCTH_2293998

CTHR:

CTHT_0073410

MGR:

MGG_15291

PPEI:

PpBr36_05578

PGRI:

PgNI_00248

TMN:	UCRPA7_3661

SSCK:

SPSK_03955

FGR:	FGSG_09156

FPU:	FPSE_06826

FPOA:

FPOAC1_012558

FVN:	FVRRES_13637

FVR:	FVEG_03645

FOX:	FOXG_05775

NHE:	NECHADRAFT_96635

FFC:	NCS54_01229600

FKR:	NCS57_01219100

FMU:	J7337_003656

TRE:	TRIREDRAFT_123561

TRR:	M419DRAFT_103000

MAW:

MAC_02797

MAJ:

MAA_05263

PCHM:

VFPPC_08791 VFPPC_12613 VFPPC_18301

CMT:

CCM_04990

AMUS:

LMH87_007434

PLJ:	VFPFJ_10175

PTKZ:

JDV02_008870(KEX2)

VAL:	VDBG_03817

VDA:	VDAG_01043

CFJ:	CFIO01_12367

CLUP:

CLUP02_13873

CHIG:

CH63R_05933

SAPO:

SAPIO_CDS6086

ELA:	UCREL1_10465

PFY:	PFICI_13288

SSL:	SS1G_06027

BFU:	BCIN_05g03290(Bckex2)

MBE:

MBM_03947

PSCO:

LY89DRAFT_572892

GLZ:	GLAREA_08402

ANI:	ANIA_03583

AFM:	AFUA_4G12970

ACT:	ACLA_051950

NFI:	NFIA_103380

AOR:	AO090009000291

ANG:	An01g08530(kexB)

AFV:	AFLA_011068

ALUC:

AKAW2_20906A(KEX2)

ACHE:

ACHE_10341A(KEX2)

APUU:

APUU_60290A(KEX2_1) APUU_60901S(KEX2_2)

PCS:	N7525_005913

PDP:	PDIP_44570

POU:	POX_a01618

TMF:	EYB26_005191

TRG:	TRUGW13939_02659

CIM:	CIMG_00625

CPW:	CPC735_056300

URE:	UREG_00628

PBL:	PAAG_07022

PBN:	PADG_01553

ABE:	ARB_00131 ARB_07953

TVE:	TRV_04084 TRV_06672

AJE:	HCAG_07015

BGH:	BDBG_02235

PNO:	SNOG_04420

PTE:

PTT_12023

BZE:	COCCADRAFT_34558

BSC:	COCSADRAFT_340340

BOR:	COCMIDRAFT_98148

AALT:

CC77DRAFT_1019478

ARAB:

EKO05_0001920

ZTR:	MYCGRDRAFT_10819(MgSPR2)

PFJ:	MYCFIDRAFT_156783

FFU:	CLAFUR5_08204

CBET:

CB0940_04355

BCOM:

BAUCODRAFT_532569

NPA:	UCRNP2_4501

TML:	GSTUM_00008707001

SPO:	SPAC22E12.09c(krp1)

SOM:	SOMG_03462(krp1)

CNE:

CNH01120

CNB:

CNBL1060

CNG:	CNAG_05446

CGI:	CGB_L1170W

CDEU:

CNBG_4411

TMS:	TREMEDRAFT_70081

TASA:

A1Q1_02903

CCAC:

CcaHIS019_0603220(KEX2)

DSQ:	DICSQDRAFT_165877

SHS:	STEHIDRAFT_145445

HIR:	HETIRDRAFT_457632

PSQ:	PUNSTDRAFT_53587 PUNSTDRAFT_70782

ADL:	AURDEDRAFT_110900 AURDEDRAFT_142208

FME:	FOMMEDRAFT_110361 FOMMEDRAFT_124597

GTR:	GLOTRDRAFT_36402

RSX:	RhiXN_02310

LBC:	LACBIDRAFT_248825 LACBIDRAFT_322240

CCI:	CC1G_01625 CC1G_02379 CC1G_12012

ABP:	AGABI1DRAFT52884(AGABI1DRAFT_52884)

ABV:	AGABI2DRAFT199236(AGABI2DRAFT_199236)

PCUB:

JR316_0003406 JR316_0008359

MRR:	Moror_4888 Moror_8398

E1B28_009092 E1B28_009100

SCM:	SCHCO_02607864(SCHCODRAFT_02607864)

WSE:	WALSEDRAFT_30910

WIC:	J056_002134

UMA:	UMAG_02843

PFP:	PFL1_01903

SGRA:

EX895_001835

MGL:

MGL_3817

MRT:

MRET_0618

MSYM:

MSY001_1822

PGR:	PGTG_08683

PTRC:

PtA15_7A657

PSTR:

Pst134EA_013699

MLR:	MELLADRAFT_34111

FCY:	FRACYDRAFT_179604

EHX:	EMIHUDRAFT_108768

DAF:	Desaf_1407

» show all

Reference

1 [PMID:6430565]

Authors

Julius D, Brake A, Blair L, Kunisawa R, Thorner J.

Title

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.

Journal

Cell 37:1075-89 (1984)
DOI:10.1016/0092-8674(84)90442-2

Reference

2 [PMID:3894003]

Authors

Achstetter T, Wolf DH.

Title

Hormone processing and membrane-bound proteinases in yeast.

Journal

EMBO J 4:173-7 (1985)
DOI:10.1002/j.1460-2075.1985.tb02333.x

Reference

3 [PMID:2845974]

Authors

Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H

Title

Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.

Journal

Biochem Biophys Res Commun 156:246-54 (1988)
DOI:10.1016/S0006-291X(88)80832-5

Sequence

[sce:YNL238W]

Reference

4 [PMID:2646633]

Authors

Fuller RS, Brake A, Thorner J.

Title

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

Journal

Proc Natl Acad Sci U S A 86:1434-8 (1989)
DOI:10.1073/pnas.86.5.1434

Sequence

[sce:YNL238W]

Reference

5 [PMID:2647083]

Authors

Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H

Title

Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae.

Journal

Biochem Biophys Res Commun 159:305-11 (1989)
DOI:10.1016/0006-291X(89)92438-8

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.61

IUBMB Enzyme Nomenclature:

3.4.21.61

ExPASy - ENZYME nomenclature database:

3.4.21.61

BRENDA, the Enzyme Database:

3.4.21.61

CAS:	99676-46-7

DBGET integrated database retrieval system