KEGG   ENZYME: 3.4.21.64
Entry
EC 3.4.21.64                Enzyme                                 
Name
peptidase K;
Tritirachium alkaline proteinase;
Tritirachium album serine proteinase;
proteinase K;
Tritirachium album proteinase K;
endopeptidase K
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyses peptide amides
Comment
From the mold Tritirachium album Limber. A peptidase of family S8 (subtilisin family) containing two disulfide bridges and one free Cys near the active site His. Formerly included in EC 3.4.21.14
History
EC 3.4.21.64 created 1992 (EC 3.4.21.14 created 1961 as EC 3.4.4.16, transferred 1972 to EC 3.4.21.14, modified 1986, part incorporated 1992)
Reference
1  [PMID:4373242]
  Authors
Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H.
  Title
Proteinase K from Tritirachium album Limber.
  Journal
Eur J Biochem 47:91-7 (1974)
DOI:10.1111/j.1432-1033.1974.tb03671.x
Reference
2
  Authors
Morihara, K. and Tsuzuki, H.
  Title
Specificity of proteinase K from Tritirachium album Limber for synthetic peptides.
  Journal
Agric Biol Chem 39:1489-1492 (1975)
Reference
3  [PMID:943367]
  Authors
Kraus E, Kiltz HH, Femfert UF.
  Title
The specificity of proteinase K against oxidized insulin B chain.
  Journal
Hoppe Seylers Z Physiol Chem 357:233-7 (1976)
Reference
4
  Authors
Jany, K.-D., Lederer, G. and Mayer, B.
  Title
Amino acid sequence of proteinase K from the mold Tritirachium album Limber.
  Journal
FEBS Lett 199:139-144 (1986)
Reference
5  [PMID:2184432]
  Authors
Betzel C, Teplyakov AV, Harutyunyan EH, Saenger W, Wilson KS.
  Title
Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes.
  Journal
Protein Eng 3:161-72 (1990)
DOI:10.1093/protein/3.3.161
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.64
IUBMB Enzyme Nomenclature: 3.4.21.64
ExPASy - ENZYME nomenclature database: 3.4.21.64
BRENDA, the Enzyme Database: 3.4.21.64
CAS: 39450-01-6

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