KEGG ENZYME: 3.4.21.70

ENZYME: 3.4.21.70

Entry

EC 3.4.21.70                Enzyme

Name

pancreatic endopeptidase E;
cholesterol-binding proteinase;
proteinase E;
cholesterol-binding serine proteinase;
pancreatic protease E;
pancreatic proteinase E;
cholesterol-binding pancreatic proteinase;
CBPP;
pancreas E proteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Preferential cleavage: Ala!. Does not hydrolyse elastin

Comment

A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol

History

EC 3.4.21.70 created 1992

Orthology

K01345

pancreatic endopeptidase E

Genes

HSA:	10136(CELA3A) 23436(CELA3B)

PTR:	456491 749169(CELA3A)

PPS:	100969372(CELA3A) 117979827

GGO:	101137143 115930425

PON:	100439784(CELA3B) 103888935(CELA3A)

NLE:	100596417(CELA3A) 100603679(CELA3B)

HMH:

116813793

MCC:	574236(CELA3B)

MCF:

102144846

MTHB:

126955738

MNI:	105494396(CELA3B)

CSAB:

103225426

CATY:

105595027(CELA3B)

PANU:

101003540(CELA3B)

TGE:

112629136

MLEU:

105546830

RRO:	104663219(CELA3B)

RBB:

108538450

TFN:	117093161(CELA3B)

PTEH:

111547719

CANG:

105505982

CJC:	100386418(CELA3B)

SBQ:	101051739(CELA3B)

CIMI:

108285822(CELA3B)

CSYR:

103265023(CELA3B)

MMUR:

105873632 105873633

LCAT:

123634881 123635871 123635872

PCOQ:

105815660(CELA3B)

OGA:

100951510

MMU:	242711(Cela3a) 67868(Cela3b)

MCAL:

110293236(Cela3b) 110293544

MPAH:

110323870(Cela3b)

RNO:	298567(Cela3b)

MCOC:

116095619(Cela3b)

ANU:

117709196

MUN:

110545009

CGE:	100765144(Cela3b)

MAUA:

101827180

PROB:

127213224(Cela3b)

PLEU:

114697144(Cela3b)

MFOT:

126509044

AAMP:

119817658

NGI:

103746435

HGL:	101701010(Cela3b)

CPOC:

100717471 100717936

CCAN:

109694914 109694922(Cela3b)

DORD:

105997932 106002125

DSP:

122115256

PLOP:

125354240

NCAR:

124994091

MMMA:

107142154

OCU:	100338830 100339081 100339326 100339575 100339830 100348247 100348913 100349163

OPI:	101516080 101516325 101517090 101517336 101517586 101517838 101517882 101518083 101518125 101518810 101519544 101533119 101533312 101533358(CELA3B)

TUP:	102489028(CELA3B)

GVR:

103598981

CFA:

478196

CLUD:

112660522

VVP:	112929845(CELA3B)

VLG:

121498156

NPO:

129513597

AML:

100464577

UMR:

103666796

UAH:

113268223

UAR:

123782443

ELK:

111154568

LLV:

125098117

MPUF:

101689657

MNP:

132001620

MLK:

131809466

NVS:

122898604

ORO:	101363663(CELA3B)

EJU:

114199048

ZCA:

113928394

MLX:	118019633(CELA3B)

NSU:

110575376

LWW:

102746812

FCA:

101094275

PYU:

121022803

PCOO:

112862179

PBG:

122480064

PVIV:

125173815

LRUF:

124516291

PTG:	102948913(CELA3B)

PPAD:

109274273

PUC:

125912992

AJU:

106977605

HHV:

120221391

BTA:	281752(CELA3B)

BOM:

102267066

BIU:

109576143

BBUB:

102404335

BBIS:

104981085

CHX:

102188098

OAS:	101103454(CELA3B)

BTAX:

128043352

ODA:

120855015

CCAD:

122426799

MBEZ:

129538609

SSC:

110261434

CFR:

102514000

CBAI:

105070878(CELA3B)

CDK:

105088866

VPC:

102530490

BACU:

103008517(CELA3B)

BMUS:

118903169

LVE:	103088740(CELA3B)

OOR:	101269800(CELA3B)

DLE:	111163341(CELA3B)

PCAD:

102976238

PSIU:

116739941

NASI:

112414336

ECB:

100071692

EPZ:

103558480

EAI:

106840005

MYB:	102258274(CELA3B)

MYD:	102758633(CELA3B)

MMYO:

118674978

MLF:	102438424(CELA3B)

PKL:	118722444(CELA3B)

EFUS:

103291972

MNA:

107538379

DRO:

112299561

SHON:

118977793(CELA3B)

AJM:

119042242

PDIC:

114497776

PHAS:

123831872

MMF:	118626695(CELA3B)

PPAM:

129068969

HAI:	109396740(CELA3B)

RFQ:

117027390

PALE:

102889614

PGIG:

120596199

PVP:

105290660

RAY:

107513056

MJV:	108391523(CELA3B)

TOD:

119236073

SARA:

101540357(CELA3B)

LAV:

100668364

TMU:

101340821

ETF:	101639739(CELA3B)

DNM:	101419793(CELA3B)

MDO:	100026235(CELA3B)

GAS:

123243129

SHR:	100925777(CELA3B)

AFZ:

127558163

PCW:	110205964(CELA3B)

OAA:	100087497(CELA3B) 114812194

GGA:	100857116(CELA3B)

PCOC:

116238335(CELA3B)

MGP:

100549082

CJO:	107323307(CELA3B)

TPAI:

128084966(CELA3B)

LMUT:

125703225(CELA3B)

NMEL:

110408690(CELA3B)

APLA:

101793005(CELA3B)

ACYG:

106048620(CELA3B)

CATA:

118258822(CELA3B)

AFUL:

116497682(CELA3B)

TGU:

115497979

LSR:	110474429(CELA3B)

SCAN:

103820866

PMOA:

120496721(CELA3B)

OTC:	121343924(CELA3B)

PRUF:

121351332

GFR:

102033802

FAB:

101821426

OMA:

130261582

PHI:	102106956(CELA3B)

PMAJ:

107213557(CELA3B)

CCW:	120411368(CELA3B)

CBRC:

103614524(CELA3B)

SVG:

106860538

MMEA:

130581850(CELA3B)

HRT:	120762308(CELA3B)

FPG:

101919146

FCH:

102046704

CLV:

102093106

EGZ:	104133200(CELA3B)

ACUN:

113487948

TALA:

116961503(CELA3B)

ACHC:

115342886(CELA3B)

HLE:	104837983(CELA3B)

AGEN:

126039657

MUI:

104548771

DPUB:

104308118

CPEA:

104395029

RTD:

128903868

CUCA:

104062263

NPD:

112959561

PSS:

106732719

CMY:	102939403(CELA3B)

CCAY:

125624361(CELA3B)

DCC:	119845067(CELA3B)

CPIC:

101931240(CELA3B)

TST:	117868083(CELA3B)

CABI:

116837892

MRV:	120387921(CELA3B)

ACS:	100556283 103281670

ASAO:

132764730 132764731 132782756

PVT:	110073187 110073188

SUND:

121936069 121936070

PBI:

103054366

PMUR:

107298788 107300865 107301723 107302144 107302253 107302304

CTIG:

120319188 120319189

PGUT:

117656551 117656561 117657366 117657538

APRI:

131186971 131186973

PTEX:

113451266 113454472

NSS:	113430907 113432050 113432077 113432151 113432351

VKO:	123018798 123018799

PMUA:

114603335 114603336

PRAF:

128420339(CELA3B) 128420340

ZVI:	118078652 118087066(CELA3B) 118087068

HCG:	128338388 128338389 128338391

GJA:	107111587 107111618

STOW:

125445497 125445807(CELA3B)

EMC:	129344701 129344740(CELA3B)

XLA:	108695955 443664(cela3a.S) 447029(cela3b.L)

XTR:	100494627 101734670 496902(ela3b) 496909(cela3a)

NPR:

108803238

RTEM:

120916182 120916183

BBUF:

120986825(CELA3B)

BGAR:

122927033(CELA3B)

MUO:	115456486 115482431

GSH:	117349076 117349078

IPU:

108275518

IFU:

128619646

PHYP:

113530350

SMEO:

124398669

TFD:

113651478

TVC:

132862647

AMEX:

103041381

CMAO:

118822365

EEE:

113570346

CHAR:

105893922 122130865

TRU:

101069690

TFS:

130539514

TNG:	GSTEN00026615G001

LCO:	104919063 104929218 104929223 104931542

NCC:	104941139 104959852

TBEN:

117489037

CGOB:

115007019 115022846

PGEO:

117462589

GACU:

117558412 117560605

EMAC:

134869131 134870247

ELY:	117253566 117254258 117271819

EFO:	125895338 125896398 125902496

PLEP:

121938372 121941158 121951654

SLUC:

116038232 116058993

ECRA:

117949925 117950108

ESP:	116695249 116696076

PFLV:

114561253 114561459

GAT:

120816456

PPUG:

119207352 119217260

AFB:	129089262 129094219 129094301

CLUM:

117729564 117746487

PSWI:

130194164 130197750

MSAM:

119900251 119900252 119901095 119902036 119916760

SCHU:

122877299 122877975

CUD:	121511749 121512284 121520529

ALAT:

119010886 119028010 119029015

MZE:

101482931

ONL:

100698021

OAU:

116331221

CSAI:

133452773 133458245

XMA:	102216966 102226343

XCO:	114146756 114151555

XHE:

116726498

PRET:

103463870 103479654

PFOR:

103135825 103137149

PLAI:

106954253

PMEI:

106921324

GAF:	122838869 122841250

PPRL:

129361818 129372999

CVG:	107090018 107094890

CTUL:

119777047 119795687

GMU:

124874132

NFU:	107383903 107393374

KMR:	108239564 108240172

ALIM:

106525022 106532600

NWH:

119414558

AOCE:

111568709 111570240 111581053

MCEP:

125009503 125010477

CSEM:

103396268

SSEN:

122767322

HHIP:

117778887

HSP:

118117544

LCF:	108878838 108879544 108883404

SDU:	111227518 111231094 111231831

SLAL:

111661093 111667454 111667509 111671616 111671767

XGL:	120790678 120798574

HCQ:

109520820

BPEC:

110154882 110159546

MALB:

109962099

BSPL:

114845103 114853684

SJO:	128361409 128361438 128369546

SASA:

100196335(cac3)

STRU:

115191540

OTW:

112248933

OMY:

110521643

OGO:

124037095

ONE:	115140660 115145489

OKI:

109897507

OKE:

118358718

SALP:

111971902 111979605

SNH:

120051856

CCLU:

121532800 121539875

ELS:	105011802 105020175

AANG:

118225540

PSPA:

121313943 121313944

ARUT:

117394614

PSEX:

120529537

LCM:

102347653

CMK:

103181355

RTP:

109918377

CPLA:

122540090 122540126 122540215

HOC:	132833550 132833559 132833677

LERI:

129711643 129711645 129711671

PMRN:

116941518 116941766 116941767 116941769 116941770

AAG:

5576508

AALB:

109420035 109420036

CQU:	CpipJ_CPIJ014969

CPII:

120429178

TUT:

107371690

PMEO:

129595121

LGI:	LOTGIDRAFT_229780

PVUL:

126823865

OED:	125670194 125680087

OSN:

115224434

NVE:

5502510

EPA:

110253281

ATEN:

116308146 116308834 116308836

ADF:	107347514 107347515

AMIL:

114970179

PDAM:

113665382 113674904 113674916 113675090

SPIS:

111337244 111341130

HMG:	100200875 100208251 100209774 100213276

HSY:	130641270 130641978 130641981

» show all

Reference

1 [PMID:234742]

Authors

Mallory PA, Travis J.

Title

Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase.

Journal

Biochemistry 14:722-30 (1975)
DOI:10.1021/bi00675a012

Reference

2 [PMID:3477287]

Authors

Shen WF, Fletcher TS, Largman C

Title

Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.

Journal

Biochemistry 26:3447-52 (1987)
DOI:10.1021/bi00386a030

Sequence

[hsa:23436]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.70

IUBMB Enzyme Nomenclature:

3.4.21.70

ExPASy - ENZYME nomenclature database:

3.4.21.70

BRENDA, the Enzyme Database:

3.4.21.70

CAS:	68073-27-8

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Gene (1299)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (499)   
   KEGG MGENES (36)   
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Protein sequence (18)   
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   SWISS-PROT (4)   
   RefSeq(pep) (8)   
DNA sequence (11)   
   RefSeq(nuc) (8)   
   GenBank (2)   
   EMBL (1)   
Protein domain (7)   
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All databases (1335)   

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