KEGG   ENZYME: 3.4.21.72
Entry
EC 3.4.21.72                Enzyme                                 
Name
IgA-specific serine endopeptidase;
IgA protease;
IgA proteinase;
IgA-specific proteinase;
immunoglobulin A protease;
immunoglobulin A proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage of immunoglobulin A molecules at certain Pro! bonds in the hinge region. No small molecule substrates are known
Comment
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase)
History
EC 3.4.21.72 created 1992
Orthology
K01347  IgA-specific serine endopeptidase
Genes
HINHI_0990
HITNTHI0354(hap) NTHI1164(iga1)
HIPCGSHiEE_07015(recF)
HIFHIBPF_12570
HILHICON_04100
HIUHIB_03070 HIB_11300(iga)
HIER2846_0355(hap1) R2846_1321(iga)
HIZR2866_0337(hap1) R2866_1393(iga)
HIKHifGL_000025(hap) HifGL_000617(iga)
HIAH733_0142 H733_1448
HIHNF38_00020 NF38_04165
HIWNTHI477_00719(iga) NTHI477_01286(hap)
HICNTHIC486_00746(hap) NTHIC486_00849(iga_1) NTHIC486_01777(iga_2)
HIXNTHI723_00624(iga) NTHI723_01451(hap)
HAYC3V42_05710
HPITNCTC13334_00036(hap1) NCTC13334_00680(recF_2)
HHZNCTC10839_00105(iga_1)
HAEGNCTC8502_00004(iga)
HPAAE5Q53_00140 E5Q53_06860
HSEML3077_03530
MHTD648_4030 D648_5830 D648_8850
MHQD650_18750 D650_21750 D650_22290 D650_24120
MHATB824_13110 B824_20940 B824_22710
MHXMHH_c09480(hap1) MHH_c11330(iga1) MHH_c11860(iga2) MHH_c14860
MHAEF382_09880 F382_10785 F382_11060 F382_12470
MHAMJ450_00010 J450_09705
MHAOJ451_10100 J451_11170
MHALN220_01980 N220_02895 N220_03165 N220_04620
MHAQWC39_09280 WC39_10700 WC39_10950 WC39_11875
MHAYVK67_09280 VK67_10700 VK67_10955 VK67_11880
MGRAA4G16_10005
MPEGHV560_03595 HV560_03695
MANNGM695_03455 GM695_03555
AAZADJ80_02965
AAHCF65_02347
AACTACT75_02845
ASEGNCTC10977_00521(hap) NCTC10977_00926(iga)
AGJJ5A60_00290 J5A60_02205
BTREF542_17690
BTRAF544_4640
APAGEIA51_06960
AVTNCTC3438_01696(iga)
OOIA6A10_09445
BHUDA6A11_08635
MNCLU297_03810 LU297_03815 LU297_04695
NMENMB0700(iga) NMB1985(hap) NMB1998
NMPNMBB_0786 NMBB_2277(app) NMBB_2295
NMHNMBH4476_1488 NMBH4476_1923 NMBH4476_1935
NMDNMBG2136_0648 NMBG2136_1876
NMMNMBM01240149_0189 NMBM01240149_0201 NMBM01240149_1392
NMSNMBM01240355_0699 NMBM01240355_1914 NMBM01240355_1927
NMQNMBM04240196_1466(iga) NMBM04240196_1922 NMBM04240196_1934
NMZNMBNZ0533_0325 NMBNZ0533_0338(hap)
NMANMA0457 NMA0905
NMWNMAA_0168(app) NMAA_0537(iga)
NMXNMA510612_0497(iga2) NMA510612_1014(iga)
NMCNMC0651(iga) NMC1959(iga2)
NMNNMCC_0223(app) NMCC_0659(iga)
NMTNMV_1699(iga) NMV_2184(app)
NMINMO_0169 NMO_0193(iga2) NMO_0592(iga1)
NGONGO_0275 NGO_2105
NGKNGK_0419 NGK_2574
NLANLA_19200(iga2)
NCZNCTC10294_01456(iga)
AFFH3L97_06990 H3L97_10965 H3L97_10970
ACRSLVJ80_11360 LVJ80_14430
CSTEH3L98_05600
PTESJQU52_13535
OTTOTT_1741(sca2)
LLMllmg_0877
LLCLACR_1726
LLRllh_4410
LLNLLNZ_04515
LLIuc509_1563
LLWkw2_1577
SMFSmon_1065
 » show all
Reference
1  [PMID:6416146]
  Authors
Plaut AG.
  Title
The IgA1 proteases of pathogenic bacteria.
  Journal
Annu Rev Microbiol 37:603-22 (1983)
DOI:10.1146/annurev.mi.37.100183.003131
Reference
2  [PMID:2105953]
  Authors
Bachovchin WW, Plaut AG, Flentke GR, Lynch M, Kettner CA
  Title
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
  Journal
J Biol Chem 265:3738-43 (1990)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.72
IUBMB Enzyme Nomenclature: 3.4.21.72
ExPASy - ENZYME nomenclature database: 3.4.21.72
BRENDA, the Enzyme Database: 3.4.21.72
CAS: 55127-02-1

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