Entry
Name
IgA-specific serine endopeptidase;
IgA protease;
IgA proteinase;
IgA-specific proteinase;
immunoglobulin A protease;
immunoglobulin A proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of immunoglobulin A molecules at certain Pro! bonds in the hinge region. No small molecule substrates are known
Comment
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC
3.4.24.13 , IgA-specific metalloendopeptidase)
History
EC 3.4.21.72 created 1992
Orthology
K01347 IgA-specific serine endopeptidase
Genes
HIT : NTHI0354(hap) NTHI1164(iga1)
HIU : HIB_03070 HIB_11300(iga)
HIE : R2846_0355(hap1) R2846_1321(iga)
HIZ : R2866_0337(hap1) R2866_1393(iga)
HIK : HifGL_000025(hap) HifGL_000617(iga)
HIH : NF38_00020 NF38_04165
HIW : NTHI477_00719(iga) NTHI477_01286(hap)
HIC : NTHIC486_00746(hap) NTHIC486_00849(iga_1) NTHIC486_01777(iga_2)
HIX : NTHI723_00624(iga) NTHI723_01451(hap)
HPIT : NCTC13334_00036(hap1) NCTC13334_00680(recF_2)
HHZ : NCTC10839_00105(iga_1)
HAEG : NCTC8502_00004(iga)
HPAA : E5Q53_00140 E5Q53_06860
MHT : D648_4030 D648_5830 D648_8850
MHQ : D650_18750 D650_21750 D650_22290 D650_24120
MHAT : B824_13110 B824_20940 B824_22710
MHX : MHH_c09480(hap1) MHH_c11330(iga1) MHH_c11860(iga2) MHH_c14860
MHAE : F382_09880 F382_10785 F382_11060 F382_12470
MHAM : J450_00010 J450_09705
MHAO : J451_10100 J451_11170
MHAL : N220_01980 N220_02895 N220_03165 N220_04620
MHAQ : WC39_09280 WC39_10700 WC39_10950 WC39_11875
MHAY : VK67_09280 VK67_10700 VK67_10955 VK67_11880
MPEG : HV560_03595 HV560_03695
MANN : GM695_03455 GM695_03555
ASEG : NCTC10977_00521(hap) NCTC10977_00926(iga)
AGJ : J5A60_00290 J5A60_02205
MNC : LU297_03810 LU297_03815 LU297_04695
NME : NMB0700(iga) NMB1985(hap) NMB1998
NMP : NMBB_0786 NMBB_2277(app) NMBB_2295
NMH : NMBH4476_1488 NMBH4476_1923 NMBH4476_1935
NMD : NMBG2136_0648 NMBG2136_1876
NMM : NMBM01240149_0189 NMBM01240149_0201 NMBM01240149_1392
NMS : NMBM01240355_0699 NMBM01240355_1914 NMBM01240355_1927
NMQ : NMBM04240196_1466(iga) NMBM04240196_1922 NMBM04240196_1934
NMZ : NMBNZ0533_0325 NMBNZ0533_0338(hap)
NMW : NMAA_0168(app) NMAA_0537(iga)
NMX : NMA510612_0497(iga2) NMA510612_1014(iga)
NMC : NMC0651(iga) NMC1959(iga2)
NMN : NMCC_0223(app) NMCC_0659(iga)
NMT : NMV_1699(iga) NMV_2184(app)
NMI : NMO_0169 NMO_0193(iga2) NMO_0592(iga1)
NCZ : NCTC10294_01456(iga)
AFF : H3L97_06990 H3L97_10965 H3L97_10970
ACRS : LVJ80_11360 LVJ80_14430
» show all
Taxonomy
Reference
Authors
Plaut AG.
Title
The IgA1 proteases of pathogenic bacteria.
Journal
Reference
Authors
Bachovchin WW, Plaut AG, Flentke GR, Lynch M, Kettner CA
Title
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
Journal
J Biol Chem 265:3738-43 (1990)
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.21.72