Entry |
|
Name |
myeloblastin;
leukocyte proteinase 3;
leukocyte proteinase 4;
Wegener's granulomatosis autoantigen;
proteinase PR-3;
proteinase-3;
PMNL proteinase
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
|
Reaction(IUBMB) |
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val!
|
Comment |
From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor
|
History |
EC 3.4.21.76 created 1993
|
Orthology |
|
Genes |
GVR: | 103607670(PRTN3) 103609792 |
XLA: | 495841(prtn3.S) 496090(prtn3.L) |
AALB: | 109414701 115255728 |
CCRN: | 123290441 123290509 |
» show all
|
Reference |
|
Authors |
Labbaye C, Musette P, Cayre YE. |
Title |
Wegener autoantigen and myeloblastin are encoded by a single mRNA. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR. |
Title |
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. |
Journal |
J Biol Chem 266:9540-8 (1991) |
Sequence |
|
Reference |
|
Authors |
Brubaker MJ, Groutas WC, Hoidal JR, Rao NV. |
Title |
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters. |
Journal |
|
Reference |
|
Authors |
Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC. |
Title |
Substrate and inhibitor studies on proteinase 3. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.21.76 |
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