KEGG   ENZYME: 3.4.21.86
Entry
EC 3.4.21.86                Enzyme                                 
Name
limulus clotting enzyme;
clotting enzyme
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of -Arg18! and -Arg47! bonds in coagulogen to form coagulin and fragments
Comment
From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)
History
EC 3.4.21.86 created 1993
Orthology
K20753  limulus clotting enzyme
Genes
LPOL: 106467688
Reference
1  [PMID:2266134]
  Authors
Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S
  Title
Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization.
  Journal
J Biol Chem 265:22426-33 (1990)
  Sequence
[ag:AAA30094]
Reference
2  [PMID:2016264]
  Authors
Tokunaga F, Nakajima H, Iwanaga S.
  Title
Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin.
  Journal
J Biochem (Tokyo) 109:150-7 (1991)
DOI:10.1093/oxfordjournals.jbchem.a123337
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.86
IUBMB Enzyme Nomenclature: 3.4.21.86
ExPASy - ENZYME nomenclature database: 3.4.21.86
BRENDA, the Enzyme Database: 3.4.21.86

  All links  
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (12)   
   UniProt (8)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (16)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (1)   
Protein domain (8)   
   InterPro (8)   
All databases (39)   

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