KEGG   ENZYME: 3.4.21.94
Entry
EC 3.4.21.94                Enzyme                                 
Name
proprotein convertase 2;
neuroendocrine convertase 2;
PC2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.94 created 1996
Orthology
K01360  proprotein convertase subtilisin/kexin type 2
Genes
HSA5126(PCSK2)
PTR458106(PCSK2)
PPS100995237(PCSK2)
GGO101144581(PCSK2)
PON100171744(PCSK2)
NLE100606456(PCSK2)
HMH116461318(PCSK2)
MCC695730(PCSK2)
MCF102139968(PCSK2)
MTHB126929184
MNI105486861(PCSK2)
CSAB103214696(PCSK2)
CATY105582050(PCSK2)
PANU101018120(PCSK2)
TGE112633217(PCSK2)
MLEU105539280(PCSK2)
RRO104676602(PCSK2)
RBB108544396(PCSK2)
TFN117068427(PCSK2)
PTEH111546421(PCSK2)
CANG105526674(PCSK2)
CJC100410189(PCSK2)
SBQ101032326(PCSK2)
CIMI108292043(PCSK2)
CSYR103256179(PCSK2)
MMUR105868534(PCSK2)
LCAT123622882(PCSK2)
PCOQ105807145(PCSK2)
OGA100944687(PCSK2)
MMU18549(Pcsk2)
MCAL110284423(Pcsk2)
MPAH110317783(Pcsk2)
RNO25121(Pcsk2)
MCOC116091050(Pcsk2)
ANU117704080(Pcsk2)
MUN110548494(Pcsk2)
CGE100771130(Pcsk2)
MAUA106021024(Pcsk2)
PROB127221370(Pcsk2)
PLEU114709434(Pcsk2)
MORG121460161(Pcsk2)
MFOT126512047
AAMP119815398(Pcsk2)
NGI103747731(Pcsk2)
HGL101710029(Pcsk2)
CPOC100727607(Pcsk2)
CCAN109679472(Pcsk2)
DORD105993720(Pcsk2)
DSP122096086(Pcsk2)
PLOP125352316(Pcsk2)
NCAR124970768
MMMA107134363(Pcsk2)
OCU100358339
OPI101517360(PCSK2)
TUP102496906(PCSK2)
GVR103603908(PCSK2)
CFA485757(PCSK2)
CLUD112673545(PCSK2)
VVP112922736(PCSK2)
VLG121477688(PCSK2)
NPO129521699(PCSK2)
AML100484456(PCSK2)
UMR103680513(PCSK2)
UAH113258239(PCSK2)
UAR123797738(PCSK2)
ELK111141692
LLV125108857
MPUF101686940(PCSK2)
MNP132021712(PCSK2)
MLK131808137(PCSK2)
NVS122916283(PCSK2)
ORO101380258(PCSK2)
EJU114216413(PCSK2)
ZCA113938351(PCSK2)
MLX118011215(PCSK2)
NSU110590033(PCSK2)
LWW102736604(PCSK2)
FCA101098130(PCSK2)
PYU121012516(PCSK2)
PCOO112868923(PCSK2)
PBG122496591(PCSK2)
LRUF124504157
PTG102951344(PCSK2)
PPAD109274692(PCSK2)
PUC125936834
AJU106967042
HHV120248232(PCSK2)
BTA281968(PCSK2)
BOM102280836(PCSK2)
BIU109568044(PCSK2)
BBUB102415434(PCSK2)
BBIS105003077(PCSK2)
CHX106503927(PCSK2)
OAS114117473 443027
BTAX128058040 128058509
ODA120868996(PCSK2)
CCAD122448749(PCSK2)
MBEZ129555341(PCSK2)
SSC445533(PCSK2)
CFR102511136(PCSK2)
CBAI105083143(PCSK2)
CDK105094118(PCSK2)
VPC102526288(PCSK2)
BACU103012983(PCSK2)
LVE103076654(PCSK2)
OOR101276250(PCSK2)
DLE111184969 111185078
PCAD102978314(PCSK2)
PSIU116740293(PCSK2)
NASI112405362(PCSK2)
ECB100050755(PCSK2)
EPZ103561885(PCSK2)
EAI106823791(PCSK2)
MYB102239561(PCSK2)
MYD102759435(PCSK2)
MMYO118663794(PCSK2)
MLF102432827(PCSK2)
MNA107536362(PCSK2)
PKL118708055(PCSK2)
EFUS103285692(PCSK2)
HAI109372764(PCSK2)
DRO112304169(PCSK2)
SHON118984882(PCSK2)
AJM119061122(PCSK2)
PDIC114506917(PCSK2)
PHAS123814658(PCSK2)
MMF118619150(PCSK2)
RFQ117016129(PCSK2)
PPAM129070888(PCSK2)
PALE102879445(PCSK2)
PGIG120611881(PCSK2)
PVP105299493(PCSK2)
RAY107520753(PCSK2)
MJV108393766(PCSK2)
TOD119232326(PCSK2) 119242620
SARA101540743(PCSK2)
LAV100659343(PCSK2)
TMU101361430
ETF101640004(PCSK2)
DNM101416376(PCSK2)
MDO100033262(PCSK2)
GAS123234761(PCSK2)
SHR100925659(PCSK2)
AFZ127548466
PCW110208376(PCSK2)
OAA100085012(PCSK2)
GGA395136(PCSK2)
PCOC116235280(PCSK2)
MGP100548840(PCSK2)
CJO107310688(PCSK2)
TPAI128077852(PCSK2)
LMUT125689022(PCSK2)
NMEL110396263(PCSK2)
APLA101791329(PCSK2)
ACYG106048665(PCSK2)
CATA118251151(PCSK2)
AFUL116488002(PCSK2)
TGU100223337(PCSK2)
LSR110484895(PCSK2)
SCAN103822198(PCSK2)
PMOA120506870(PCSK2)
OTC121335864(PCSK2)
PRUF121358756(PCSK2)
GFR102034686(PCSK2)
FAB101808403(PCSK2)
OMA130251508(PCSK2)
PHI102111890(PCSK2)
PMAJ107202341(PCSK2)
CCAE111926118(PCSK2)
CCW104696571(PCSK2)
CBRC103617205(PCSK2)
ETL114058803(PCSK2)
ZAB102063514(PCSK2)
ACHL103809599(PCSK2)
SVG106863229(PCSK2)
MMEA130575246(PCSK2)
HRT120750420(PCSK2)
FPG101924281(PCSK2)
FCH102046561(PCSK2)
CLV102088621(PCSK2)
EGZ104122531(PCSK2)
NNI104022491(PCSK2)
PCRI104027279(PCSK2)
PLET104626782(PCSK2)
EHS104513798(PCSK2)
PCAO104047597(PCSK2)
ACUN113477999(PCSK2)
TALA104358328(PCSK2)
PADL103920513(PCSK2)
AFOR103901650(PCSK2)
ACHC115344536(PCSK2)
HALD104312650
HLE104836443(PCSK2)
AGEN126038426
GCL127014213
CCRI104164777(PCSK2)
MUI104536743(PCSK2)
BREG104632403(PCSK2)
FGA104077143(PCSK2)
GSTE104257903(PCSK2)
LDI104354308(PCSK2)
MNB103780818(PCSK2)
OHA104332924(PCSK2)
NNT104411689(PCSK2)
SHAB115609680(PCSK2)
DPUB104305994(PCSK2)
PGUU104463966(PCSK2)
ACAR104532040(PCSK2)
CPEA104390984(PCSK2)
AVIT104275039(PCSK2)
CVF104283269(PCSK2)
RTD128907412(PCSK2)
CUCA104055448(PCSK2)
BRHI104499218(PCSK2)
AAM106496400(PCSK2)
AROW112961092(PCSK2)
NPD112945085(PCSK2)
TGT104564754(PCSK2)
DNE112989352(PCSK2)
SCAM104143481(PCSK2)
ASN102373017(PCSK2)
AMJ102576051(PCSK2)
CPOO109319520(PCSK2)
GGN109296915(PCSK2)
PSS102463058(PCSK2)
CMY102939591(PCSK2)
CCAY125633454(PCSK2)
DCC119853688(PCSK2)
CPIC101951129(PCSK2)
TST117874087(PCSK2)
CABI116840008(PCSK2)
MRV120401432(PCSK2)
ACS100564235(pcsk2)
ASAO132780445(PCSK2)
PVT110088789(PCSK2)
SUND121919837(PCSK2)
PBI103053916(PCSK2)
PMUR107283169(PCSK2)
CTIG120310661
TSR106542372(PCSK2)
PGUT117674425(PCSK2)
APRI131197647(PCSK2)
PTEX113444230(PCSK2)
NSS113412708(PCSK2)
VKO123035864(PCSK2)
PMUA114593687(PCSK2)
PRAF128409983(PCSK2)
ZVI118082473(PCSK2)
HCG128339967(PCSK2)
GJA107116988(PCSK2)
STOW125438196
EMC129343477(PCSK2)
XLA373675(pcsk2.L) 444586(pcsk2.S)
XTR100036632(pcsk2)
NPR108793310(PCSK2)
RTEM120937785(PCSK2)
BBUF120999305(PCSK2)
BGAR122935639(PCSK2)
MUO115465689(PCSK2)
GSH117358024(PCSK2)
DRE100004460(pcsk2)
SRX107719546(pcsk2) 107727889
SANH107699156 107701967
SGH107561970 107573254
CCAR109065357(pcsk2)
CAUA113057406 113113092
CGIB127969646 128026550
PTET122335481 122335483(pcsk2)
LROH127174793(pcsk2)
OMC131552783(pcsk2)
PPRM120492369(pcsk2)
RKG130103842(pcsk2)
MAMB125277521(pcsk2)
CIDE127525198
MASI127412310 127413928
TROS130559111(pcsk2)
TDW130432213(pcsk2)
MANU129416255(pcsk2)
IPU108262286
IFU128605267(pcsk2)
PHYP113542135(pcsk2)
SMEO124403240(pcsk2)
TFD113655412(pcsk2)
TVC132847004(pcsk2)
AMEX103033370(pcsk2) 103039520
CMAO118810137(pcsk2)
EEE113585930(pcsk2)
CHAR105892728(pcsk2)
TRU101068590(pcsk2) 101070282
TFS130534025(pcsk2)
TNGGSTEN00016397G001
LCO104930725(pcsk2)
NCC104955826(pcsk2)
TBEN117499911(pcsk2)
CGOB115020186(pcsk2)
PGEO117459288(pcsk2)
GACU117560906(pcsk2)
ELY117248386(pcsk2)
EFO125903111(pcsk2)
PLEP121954547(pcsk2)
SLUC116055069(pcsk2)
ECRA117960430(pcsk2)
ESP116705553(pcsk2)
PFLV114572158(pcsk2)
GAT120820648(pcsk2)
PPUG119214010(pcsk2)
AFB129092246(pcsk2)
CLUM117744078(pcsk2)
MSAM119917635(pcsk2)
SCHU122884577(pcsk2)
CUD121510697(pcsk2)
ALAT119033989(pcsk2)
MZE101470601(pcsk2)
ONL100534405(pcsk2)
OAU116333735(pcsk2)
OLA100049241(pcsk2)
OML112161964(pcsk2)
XMA102231965(pcsk2)
XCO114138283(pcsk2)
XHE116713436(pcsk2)
PRET103476807(pcsk2)
PFOR103133516(pcsk2)
PLAI106947443(pcsk2)
PMEI106915462(pcsk2)
GAF122842986(pcsk2)
PPRL129360133(pcsk2)
CVG107089286(pcsk2)
CTUL119790858(pcsk2)
GMU124859577(pcsk2)
NFU107376020(pcsk2)
KMR108245432(pcsk2)
ALIM106513600(pcsk2)
NWH119419217(pcsk2)
AOCE111575540(pcsk2)
MCEP125018824(pcsk2)
CSEM103387697(pcsk2)
POV109629655(pcsk2)
SSEN122781804(pcsk2)
HHIP117775550(pcsk2)
HSP118119407(pcsk2)
LCF108897258
SDU111235221(pcsk2)
SLAL111670048(pcsk2)
XGL120796104(pcsk2)
HCQ109512729(pcsk2)
SSCV125978557
SBIA133510256(pcsk2)
PEE133409613(pcsk2)
PTAO133485983(pcsk2)
BPEC110157135(pcsk2)
MALB109960189(pcsk2)
BSPL114870766(pcsk2)
SJO128373131(pcsk2)
SASA106576998(pcsk2) 106607177(NEC2)
STRU115153213 115193769
OTW112253023(pcsk2) 112254478
OMY110502463 110528870(pcsk2)
OGO124038252 124041260(pcsk2)
ONE115113227 115135108
OKI109889940(pcsk2) 109899106
OKE118369712(pcsk2) 118400241
SALP111952031 111977791
SNH120017928(pcsk2) 120045675
CCLU121553379(pcsk2) 121570819
ELS105010665(pcsk2)
SFM108927161(pcsk2) 108933539
PKI111859393(pcsk2)
AANG118217939 118218362(pcsk2)
LOC102684877(pcsk2)
PSPA121316109 121317233
ARUT117403276 117972516
PSEX120516353(pcsk2)
LCM102352855(PCSK2)
CMK103177907(pcsk2)
RTP109916953
CPLA122553106(pcsk2)
HOC132819532(pcsk2)
LERI129695066(pcsk2)
PMRN116939757(PCSK2)
LRJ133347050(PCSK2)
BFO118418937
BBEL109477140
CIN100181292(cipc2)
SCLV120327027
SPU579017
LPIC129265223
APLC110979638
AJC117105634
SKO100377458(PCSK2)
DMEDmel_CG6438(amon)
DER6555399
DSE6617074
DSIDsimw501_GD18123(Dsim_GD18123)
DYADyak_GE10618
DAN6501342
DSR110186785
DPO4801332
DPE6588537
DMN108157544
DWI6651467
DGR6564437
DMODmoj_GI24730
DAZ108608635
DNV108659743
DHE111595913
DVI6634920
CCAT101451751
BOD106619189
BDR105227005
RZE108354669 108358306
AOQ129235498
TDA119676081
MDE101898851
SCAC106093803
LCQ111674565
LSQ119602282
GFS119641728
ECOE129942097
CLON129611764
HIS119651742
AGA1269379
ACOZ120947236
AARA120894120
AMER121603559
ASTE118504559
AFUN125765923
AMOU128309905
AALI118456826
AAG5564601
CQUCpipJ_CPIJ012757
CPII120425703
CNS116338383
BCOO119069360
AME408835
ACER107994313
ALAB122714812
ADR102671853
AFLR100866084
BIM100742794
BBIF117207586
BVK117230983
BVAN117159273
BTER100643887
BAFF126921960
BPYO122567793
BPAS132912777
FVI122537275
CCAL108627030
OBB114877298
OLG117602708
MGEN117224878
NMEA116432650
CGIG122399076
SOC105203804
MPHA105836432
AEC105147744
ACEP105620261
PBAR105426716
VEM105561866
HST105182032
DQU106746237
CFO105257823
FEX115236096
LHU105674509
PGC109855266
OBO105288202
PCF106786031
PFUC122525919
VPS122633063
VCRB124427840
VVE124952820
NVI100116354
CSOL105364830
TPRE106650164
LHT122498459
LBD127280500
MDL103573332
CGLO123266032
FAS105270270
DAM107036026
AGIF122853164
CINS118067914
VCAN122410143
CCIN107263285
DSM124408242
NPT124217896
NFB124181299
NLO107225795
NVG124303838
AROA105692395
TCA661336
DPA109535104
SOY115880323
AGRG126735256
ATD109594697
CSET123307847
AGB108909206
LDC111511946
NVL108562637
APLN108736387
PPYR116172692
OTU111418869
BMOR101740216
BMAN114246427
MSEX115453010 115455278
BANY112058357
MJU123874843
NIQ126775961
VCD124538251
MCIX123662200
PMAC106719619 106721647
PPOT106110445
PXU106119922
PRAP110994302
PBX123716616
PNAP125059948
ZCE119828501
CCRC123699680
LSIN126966140
HAW110377468
HZE124639980
TNL113498528
SLIU111350287
OFU114362794
PXY105390833
PGW126375128
CFEL113375187
CCRN123292934
API100167562
DNX107161769 107161799
AGS114119692
RMD113555949
ACOO126844167
DVT126900007
BTAB109043545
DCI103511271
CLEC112126413
HHAL106685325
NLU111057277 111062474
HVI124371878
MQU128985528
PHUPhum_PHUM354430
FOC113203115 127749951
TPAL117650796
ZNE110830089
CSEC111865371
SGRE126266626
IEL124167752
FCD110843872
DPXDAPPUDRAFT_193075
DMK116931096
DPZ124327055
PVM113827760
PJA122251134
PCHN125025999
PMOO119576977
HAME121875763
PCLA123765084
CQD128703341
PTRU123518529
ESN126987833
HAZT108671730
EAF111706660
LSM121122294
TCF131884160
PPOI119093727
ISC8034786
DSV119453738 119464287
RSAN119401392
RMP119164045
VDE111247174
VJA111259967
TUT107370069
DPTE113795626
DFR124499025
CSCU111627047
PTEP107452671
UDV129224015
SDM118180923
LPOL106459205
PMEO129584982
CELCELE_C51E3.7(egl-3)
CBRCBG_09536(Cbr-egl-3)
CRQGCK72_017605
NAINECAME_01697 NECAME_12953
BMYBM_BM2886(Bma-egl-3)
LOALOAG_16369
TSPTsp_03058 Tsp_03058a
HROHELRODRAFT_96355
LGILOTGIDRAFT_212426
PCAN112570448
BGT106073932
GAE121370855
HRF124141952
HRJ124287366
CRG105337074 105340113
CVN111125728 111125730 111130394
CANU128157396 128175454 128185202 128186002
OED125649577
MYI110462057
PMAX117323912 117328224
MCAF127698734
MMER123536670 123550436
RPHI132725002 132725003 132731113 132734671 132737329 132745221 132745222 132755075
DPOL127843860 127873116
OBI106876825
OSN115229259
LAK106180256
SMMSmp_077980
SHXMS3_00006538(PCSK2)
OVIT265_05982
EGLEGR_08746
TVATVAG_2v0221310 TVAG_2v0621030 TVAG_2v0621280 TVAG_2v0931330
LMIRNCTC12852_01159(prcA_4)
LBILEPBI_I3281
LBFLBF_3168
 » show all
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415
  Sequence
[mmu:18549]
Reference
2  [PMID:2154467]
  Authors
Smeekens SP, Steiner DF.
  Title
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
  Journal
J Biol Chem 265:2997-3000 (1990)
  Sequence
[hsa:5126]
Reference
3  [PMID:8159732]
  Authors
Rouille Y, Westermark G, Martin SK, Steiner DF.
  Title
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
  Journal
Proc Natl Acad Sci U S A 91:3242-6 (1994)
DOI:10.1073/pnas.91.8.3242
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.94
IUBMB Enzyme Nomenclature: 3.4.21.94
ExPASy - ENZYME nomenclature database: 3.4.21.94
BRENDA, the Enzyme Database: 3.4.21.94
CAS: 388092-42-0

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