KEGG   ENZYME: 3.4.21.96
Entry
EC 3.4.21.96                Enzyme                                 
Name
lactocepin;
CEP;
extracellular lactococcal proteinase;
lactococcal cell wall-associated proteinase;
lactococcal cell envelope-associated proteinase;
lactococcal proteinase;
PrtP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Endopeptidase activity with very broad specificity, although some subsite preferences have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position [1,2]. Best known for its action on caseins, although it has been shown to hydrolyse hemoglobin and oxidized insulin B chain
Comment
Associated with the cell envelope of Lactococcus lactis and attached via a C-terminal membrane anchor sequence. Responsible for the hydrolysis of casein in milk and the provision of peptides essential to cell growth. Important in cheese making and the production of lactic casein, being required for rapid growth to high cell densities with concomitant production of adequate levels of lactic acid. Specificity differences between lactocepins from different starter strains may be partly responsible for imparting different flavour qualities to cheese [4]. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.96 created 1997
Orthology
K01361  lactocepin
Genes
BIFN288_23445 N288_23500
BACAFAY30_20820 FAY30_20825 FAY30_24965
BCAOLC087_11965
BHKB4U37_19395 B4U37_19815
BCIRC2I06_16645
NTXNQZ71_03590
PKSIE339_15500
BONA361_04255 A361_13995
BKOCKF48_12445
CGOTJ1899_20130
CFIRNAF01_12890 NAF01_22690
CPSSM5V91_07290
BDAFSZ17_04550 FSZ17_12620 FSZ17_20470 FSZ17_20475
OIHOB2932
OCNCUC15_17260
GLIGLN3_08555
ASEDIRT44_11010
LYGC1N55_05940
HHDHBHAL_4441(prtB)
HMNHM131_05000
HLIHLI_15100
VIRX953_17025
VHLBME96_16515
VIGBKP57_08010
VILCFK37_08165 CFK37_18495
VNECFK40_03415
VPNA21D_00884(prtP)
VPTKBP50_19555
BSJUP17_23975
BMURABE28_022660
PBUTDTO10_10495
PPSRI6J18_15810 I6J18_15875
PSYHD0S48_10095
PSYOPB01_04215
PRDF7984_05485
NMKCHR53_27575
NNVQNH39_23045 QNH39_26995
MDGK8L98_14920
BAGBcoa_0671
BVJI5776_03425 I5776_04360 I5776_11660
BOUI5818_03340
BSEBsel_0952
GAJMY490_01800 MY490_16435 MY490_16635 MY490_19985 MY490_21860
PSUAFLK61_38100
ESIExig_2784
EATEAT1b_0612
EANEab7_2593
EXMU719_15145
EXUESP131_00790
EAPKB235_07375
EACEKKI46_15030
EAURNMQ00_06095
EMMPTI97_08780
EPFOE059_05795
GMONCTC11323_01630(scpA_2)
GSAFOC50_04735
GHANCTC10459_00978(scpA_2)
BBEBBR47_16870
BLRBRLA_c011750
BFMBP422_03620
BAGRBA6348_20420
BRWGOP56_21745
BCHSJNE38_09300
BCOPJD108_15990
BPABPSE45_08435
BAYDBSPP4475_14510
BBORRFB14_18250
PTAHPL003_05920
PKBB4V02_00795
PALBEJC50_25430
PLNPlano_2351 Plano_2352
PKUAUO94_03885 AUO94_03935
PRTAUC31_14350
PLLI858_011040 I858_011050
PANABBH88_07155 BBH88_07160
PDGBCM40_03435 BCM40_03440
PHCBBI08_08995 BBI08_09010
PPLABBI15_07970
PFAEAJGP001_13610 AJGP001_13655
PMATBBI11_13605
PDECH1Q58_12895
PGQFK545_02935
JEOJMA_29650
RSTATY39_00450
PANCE2636_11650
PLAYDNR44_007905
VIJJNUCC6_17910
LLDP620_14670
LLCLACR_C42
LLIuc509_p6025(prtP)
SPYSPy_0416(prtS)
SPZM5005_Spy0341
SPYMM1GAS476_0408
SPYAA20_0393(prtS)
SPMspyM18_0464
SPGSpyM3_0298(prtS)
SPSSPs1559
SPHMGAS10270_Spy0340(spyCEP)
SPIMGAS10750_Spy0339
SPJMGAS2096_Spy0361(spyCEP)
SPKMGAS9429_Spy0344(spyCEP)
SPFSpyM51518(prtS)
SPAM6_Spy0367
SPBM28_Spy0329(prtS)
STGMGAS15252_0367(scpC)
STXMGAS1882_0367(scpC)
SOZSpy49_0336(prtS)
STZSPYALAB49_000373
SPYHL897_01865
SPYOSTAB901_01945
SAGSAG0676 SAG2053
SANgbs2008
SAKSAK_1991(cspA)
SGCA964_0672
SAGMBSA_20410 BSA_7630
SAGIMSA_21100
SAGRSAIL_20570 SAIL_8230
SAGTGBSCOH1_0599 GBSCOH1_1324 GBSCOH1_1853
SAGEEN72_04115 EN72_10755
SAGGEN73_03815 EN73_07215 EN73_09815
SAGNW903_1958
SAGJID870_10430
STESTER_0846
STUSTH8232_0989(prtS)
STWY1U_C1057
STHET303_05205
SSASSA_1882(prtS)
SSBSSUBM407_1843
SSUSSU05_0812 SSU05_1982
SSVSSU98_0812 SSU98_1986
SSISSU0757(prtS) SSU1773
SSSSSUSC84_1795
SSFSSUA7_1803
SSWSSGZ1_0794 SSGZ1_1797
SUPYYK_03620 YYK_08535
SSUSNJAUSS_0853 NJAUSS_1827
SSTSSUST3_0948(prtS) SSUST3_1819
SSUYYB51_4690 YB51_8995
SSKSSUD12_0974(prtS) SSUD12_1949
SSQSSUD9_2003
SUISSUJS14_0893(prtS) SSUJS14_1942
SUOSSU12_0755(prtS) SSU12_1919
SRPSSUST1_1876
SSUTTL13_1002(scpC) TL13_1785
SSUIT15_1146 T15_2054
SGOSGO_0316 SGO_0317 SGO_0566(sgc)
SEZSez_0511(scpC)
SEQSZO_14810(scpC)
SEZOSeseC_00614
SEQUQ426_06735
SEUSEQ_0563(scpC)
SUBSUB0826
SGAGALLO_0748
SGGSGGBAA2069_c07210(prtS)
SGTSGGB_0730
SMBsmi_1398
SORSOR_1341
SCPHMPREF0833_11142 HMPREF0833_11143 HMPREF0833_11982
SCFSpaf_0194 Spaf_1710 Spaf_1711
STDSPPN_04145
SIFSinf_0588
SIESCIM_0310(prtS)
SIBSIR_1402
SIKK710_1518
SIQDQ08_07065
SIODW64_07050
SIZSI82_07175
SIGN596_09505
SIPN597_01470
STVV470_06485
STRAATM98_08980
SRQSR187_3390 SR187_5315
SKID7D50_00685 D7D50_05105 D7D50_05110
SMENSAMEA4412692_0667(prtS)
SCAINCTC12191_00010(scpA_1) NCTC12191_00094(scpA_2)
SPSUNCTC13786_01763(scpA_3)
SPOCNCTC10925_01391(scpA_2)
SLATJ4854_02480
SAUPNCTC3168_00288(sgc) NCTC3168_01115(scpA_1) NCTC3168_01116(scpA_2)
SVFNCTC3166_00485(sgc) NCTC3166_01632(scpA_2) NCTC3166_01633(scpA_3)
SOSINT76_05155
SRUMGPZ88_07555
SMIENCTC11169_00304(scpA_1)
SRUNLPB404_03015
FPENKIW23_06090
LJOLJ_1840
LACLBA1512
LADLA14_1506
LAFSD55_1486
LDBLdb1189(prtB)
LBULBUL_1105
LDELDBND_1068(prtB)
LDLLBU_1015
LHLLBHH_1000
LHRR0052_02335
LHVlhe_1057 lhe_1521(prtH3) lhe_1677 lhe_1828
LHHLBH_1366
LHDHUO_03050 HUO_05935
LAMLA2_02705
LAILAC30SC_02045 LAC30SC_02600
LKEWANG_0583 WANG_p1075(prtP)
LGLAO203_08340
LTAH1A07_09155
LUUH4B44_07395
LIQKBW87_08600
LCALSEI_2270
LCZLCAZH_2241
LCSLCBD_2450
LCELC2W_2433
LCWBN194_24060(prtP)
LCLLOCK919_2451
LPQAF91_10945
LPILBPG_02189
LPAPLBPC_2201
LCBLCABL_24520(prtP)
LCXLCA12A_2709
LRHLGG_02274(prtP)
LRGLRHM_2185
LRLLC705_02265(prtP)
LRALRHK_2273(prtP)
LROLOCK900_2235
LRCLOCK908_2331
LZEKG087_10625 KG087_13675
LHNLHUE1_000374
LBHLbuc_2133
LBNLBUCD034_2232(prtR)
LSJLSJ_2067
LANIFAX13_01715
LMURCPS94_07230
LPSEFGL85_04465 FGL85_07025
WDIH9L19_04105
WEIEQG49_07275
XAKKIMC2_02540 KIMC2_03440
XAPXA3_17410
VTEBHY08_02880
VPIBW732_10825
VLCG314FT_10810(prtP)
CMLBN424_3077(prtB)
CDJBFC22_11330
DPMFNV33_03190
CPFCPF_1123
CPRCPR_0968(prtP)
CNONT01CX_0021
CBNCbC4_1800
CLTCM240_2101
CARGRSJ17_18790
CSEPCP523_06310
CGASJ1C67_10905
CCAAKQH81_02385 KQH81_13145
CMAHC1I91_26075 C1I91_26085
HHWNCTC503_00485(prtP_1) NCTC503_00569(prtP_2)
CALEFDN13_06835
CLOHMPREF0868_1390
RALRumal_1455
VCOPMM50RIKEN_03730 MM50RIKEN_04140
FMSM1R53_00320 M1R53_01900
BPBbpr_I2629
BFICIY_15260
PXVFXF36_14270
ACELacsn021_09830
ACHTbsdcttw_09010
PBQC3V37_03115 C3V37_05360 C3V37_05370
TTETTE2615(AprE3)
TEXTeth514_2308
THXThet_2357
TPDTeth39_0143
TBOThebr_0149
TWIThewi_2603
TKITKV_c23360(amyB)
FMAFMG_0035
PMICNW74_00080
AMEILV469_04180
SPOAEQM13_03095 EQM13_05570
CAZOG3A45_10660
SEDZJYG23_02360 JYG23_11375
ECOUM1R54_03910 M1R54_06075
ERHERH_0260
ERSK210_08505
ERDG7062_00440
DDTAAY81_08710
CBACJI75_01655
ACITHPK19_14580 HPK19_19915 HPK19_21360 HPK19_22295 HPK19_25000
BFABfae_23940
DVADAD186_00060 DAD186_20190
DJJCOP05_00345 COP05_00880
PRAPALO_11170
AHEArch_1015
ARCAHC352_04935
APHOJTE88_05205
TPYCQ11_03835
TPYOX956_03895
TPECHLG82_03160
TBERQPC17_05880
ATIMCYJ17_0003575
SOOFBF35_07220
ACTPB6G06_00300
ACTCCHIBA101_0103
AMAMHPC72_00330
AVUBK816_01255
GVGHMPREF0421_20481
GVAHMPREF0424_0423
GVHHMPREF9231_1074
SIJSCIP_0787
PDOPSDT_1426
CPOCOPRO5265_0081
CEXCSE_15380
 » show all
Reference
1  [PMID:1367552]
  Authors
Visser S, Robben AJ, Slangen CJ.
  Title
Specificity of a cell-envelope-located proteinase (PIII-type) from Lactococcus lactis subsp. cremoris AM1 in its action on bovine beta-casein.
  Journal
Appl Microbiol Biotechnol 35:477-83 (1991)
DOI:10.1007/bf00169753
Reference
2  [PMID:1592148]
  Authors
Monnet V, Ley JP, Gonzalez S.
  Title
Substrate specificity of the cell envelope-located proteinase of Lactococcus lactis subsp. lactis NCDO 763.
  Journal
Int J Biochem 24:707-18 (1992)
DOI:10.1016/0020-711x(92)90004-k
Reference
3  [PMID:8285671]
  Authors
Exterkate FA, Alting AC, Bruinenberg PG.
  Title
Diversity of cell envelope proteinase specificity among strains of Lactococcus lactis and its relationship to charge characteristics of the substrate-binding region.
  Journal
Appl Environ Microbiol 59:3640-7 (1993)
DOI:10.1128/AEM.59.11.3640-3647.1993
Reference
4  [PMID:8398214]
  Authors
Pritchard GG, Coolbear T.
  Title
The physiology and biochemistry of the proteolytic system in lactic acid bacteria.
  Journal
FEMS Microbiol Rev 12:179-206 (1993)
DOI:10.1111/j.1574-6976.1993.tb00018.x
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.96
IUBMB Enzyme Nomenclature: 3.4.21.96
ExPASy - ENZYME nomenclature database: 3.4.21.96
BRENDA, the Enzyme Database: 3.4.21.96
CAS: 205510-58-3

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