| Entry |
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| Name |
streptopain;
Streptococcus peptidase A;
streptococcal cysteine proteinase;
Streptococcus protease
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
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| Reaction(IUBMB) |
Preferential cleavage with hydrophobic residues at P2, P1 and P1'
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| Comment |
From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10.
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| History |
EC 3.4.22.10 created 1961 as EC 3.4.4.18, transferred 1972 to EC 3.4.22.10
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| Orthology |
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| Genes |
| SPYM: | M1GAS476_1785(speB) |
| SPH: | MGAS10270_Spy1803(speB) |
| SPI: | MGAS10750_Spy1828(speB) |
| SPJ: | MGAS2096_Spy1767(speB) |
| SPK: | MGAS9429_Spy1743(speB) |
| STG: | MGAS15252_1579(speB) |
| SPSU: | NCTC13786_00963(speB_1) |
| SPOC: | NCTC10925_00258(speB_2) |
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| Reference |
1 |
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| Authors |
Elliott, S.D. and Liu, T.-Y. |
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| Title |
Streptococcal proteinase. |
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| Journal |
Methods Enzymol 19:252-261 (1970) |
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| Reference |
2 |
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| Authors |
Liu, T.-Y. and Elliott, S.D. |
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| Title |
Streptococcal proteinase. |
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| Journal |
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., Academic Press, New York, 1971, p. 609-647. |
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| Reference |
|
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| Authors |
Tai JY, Kortt AA, Liu TY, Elliott SD. |
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| Title |
Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain. |
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| Journal |
J Biol Chem 251:1955-9 (1976) |
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| Sequence |
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| Reference |
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| Authors |
Lo SS, Fraser BA, Liu TY. |
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| Title |
The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis. |
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| Journal |
J Biol Chem 259:11041-5 (1984) |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.22.10 |
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