KEGG   ENZYME: 3.4.22.28
Entry
EC 3.4.22.28                Enzyme                                 
Name
picornain 3C;
picornavirus endopeptidase 3C;
poliovirus protease 3C;
rhinovirus protease 3C;
foot-and-mouth protease 3C;
poliovirus proteinase 3C;
rhinovirus proteinase 3C;
coxsackievirus 3C proteinase;
foot-and-mouth-disease virus proteinase 3C;
3C protease;
3C proteinase;
cysteine proteinase 3C;
hepatitis A virus 3C proteinase;
protease 3C;
tomato ringspot nepovirus 3C-related protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Selective cleavage of Gln!Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Comment
From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3
History
EC 3.4.22.28 created 1992
Orthology
K25299  Enterovirus protease 3C
K25922  Hepatitis A virus protease 3C
Reference
1  [PMID:3016701]
  Authors
Ivanoff LA, Towatari T, Ray J, Korant BD, Petteway SR Jr.
  Title
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 83:5392-6 (1986)
DOI:10.1073/pnas.83.15.5392
Reference
2  [PMID:3186696]
  Authors
Bazan JF, Fletterick RJ.
  Title
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
  Journal
Proc Natl Acad Sci U S A 85:7872-6 (1988)
DOI:10.1073/pnas.85.21.7872
Reference
3  [PMID:3052288]
  Authors
Krausslich HG, Wimmer E.
  Title
Viral proteinases.
  Journal
Annu Rev Biochem 57:701-54 (1988)
DOI:10.1146/annurev.bi.57.070188.003413
Reference
4  [PMID:2846872]
  Authors
Nicklin MJ, Harris KS, Pallai PV, Wimmer E.
  Title
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.
  Journal
J Virol 62:4586-93 (1988)
DOI:10.1128/JVI.62.12.4586-4593.1988
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.28
IUBMB Enzyme Nomenclature: 3.4.22.28
ExPASy - ENZYME nomenclature database: 3.4.22.28
BRENDA, the Enzyme Database: 3.4.22.28
CAS: 97162-88-4

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Gene (8)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (6)   
Protein sequence (6886)   
   UniProt (6477)   
   SWISS-PROT (86)   
   RefSeq(pep) (2)   
   PDBSTR (310)   
   PMD (11)   
DNA sequence (11)   
   RefSeq(nuc) (4)   
   GenBank (5)   
   EMBL (2)   
3D Structure (162)   
   PDB (162)   
Protein domain (34)   
   InterPro (34)   
All databases (7101)   

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