Entry
Name
caspase-1;
interleukin 1beta-converting enzyme;
protease VII;
protease A;
interleukin 1beta precursor proteinase;
interleukin 1 converting enzyme;
interleukin 1beta-converting endopeptidase;
interleukin-1beta convertase;
interleukin-1beta converting enzyme;
interleukin-1beta precursor proteinase;
prointerleukin 1beta protease;
precursor interleukin-1beta converting enzyme;
pro-interleukin 1beta proteinase;
ICE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp!
Comment
From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC
3.4.22.57 ) and caspase-5 (EC
3.4.22.58 ) in humans and caspase-11 (EC
3.4.22.64 ), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.
History
EC 3.4.22.36 created 1993, modified 1997, modified 2007
Orthology
Genes
PPS : 100985633 100986637(CASP1)
PON : 100437679(CASP1) 100442809
MTHB : 126936244 126936247 126936524
CSAB : 103248363 103248365(CASP1) 103248933
CATY : 105588753 105588757
PANU : 101006831(CASP1) 101008696 101009375
TGE : 112605777(CASP1) 112605780 112605953 112605954
MLEU : 105534146 105534147(CASP1) 105534152
RRO : 104665271(CASP1) 104665273 104665280
RBB : 108513176 108513177 108513179(CASP1)
TFN : 117080358(CASP1) 117080362
PTEH : 111540082(CASP1) 113222446(CARD16)
CANG : 105500956(CASP5) 105500957 105501187
CPOC : 100725217 100730749
MYB : 102247565 102258149(CASP1)
MDO : 100032592 100032596 100032610
NMEL : 110407545 110407549(CARD16)
PGUT : 117667558 117667559
XLA : 378669(casp1.S) 397719(casp1.L)
DRE : 566185(caspbl) 57933(caspa)
SRX : 107713782 107719146 107723996 107737821 107738044 107748007
SANH : 107659780 107666787 107679276 107683527 107685936
SGH : 107558420 107570904 107571421 107571890 107573577 107574341 107592160 107600521
CCAR : 109055187 109059688 109062412 109079016 109089143 109093960 109094019
CAUA : 113052249 113059546 113074243 113082415 113105593 113115174 113115897
CGIB : 127975488 128029032 128030415
PTET : 122360331(caspa) 122360767
OMC : 131522386(caspa) 131537445 131537504 131537508 131547693 131547742
MAMB : 125242858(caspa) 125271030 125271512
CIDE : 127496856 127508390 127511353
MASI : 127453477 127454625
TDW : 130433600(caspa) 130433602
AMEX : 103021832 103039157 103043169 111188785
CMAO : 118798716 118799123
CHAR : 105908639 122133338(caspa)
TFS : 130534928 130535589 130535590
TBEN : 117470464(caspa) 117482809
PGEO : 117455465 117457271(caspa)
PFLV : 114552537 114552861
GAT : 120814011 120814012 120824590(caspa)
PPUG : 119217527 119217533
PSWI : 130210600 130210609
MSAM : 119883616 119883617 119891577
ALAT : 119031242 119031258
MZE : 101463887 101464464 101468196 101481357 112429920 112431722 112432409
ONL : 100702756 100708116 100708386 102079862 102081456(card16) 102082075 106097268 112846027
OAU : 116310644 116323593 116323605 116323606 116328039 120434310 120439261
CSAI : 133441804 133441807 133442377
XMA : 102220363 102220624 102229031 111605766
XCO : 114133584 114133591 114133592 114142065
XHE : 116708295 116717316 116737431
PRET : 103474681 103477732
PFOR : 103136355 103148109 103154678 107833734
PLAI : 106939894 106950220 106952931 106952932 106952936
PMEI : 106908161 106917731 106917742 106920431
GAF : 122832182 122832183 122833093
PPRL : 129369807 129369976 129370003
CVG : 107081895 107081897 107081901
CTUL : 119797303 119797316
GMU : 124884212 124884250 124884286
ALIM : 106519401 106533471
MCEP : 125013084 125013085
SSCV : 125972695 125972696
SJO : 128353177 128353178 128354004 128359924 128360330 128360332 128360388 128366902
SALP : 111959666 111982518
SNH : 120018779 120029080 120036891 120037031 120042531 120051700
CCLU : 121567657 121567662
LOC : 102688855 102696999(casp1)
ARUT : 117414382 117429871 117430514
» show all
Taxonomy
Reference
Authors
Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DD, Mumford RA, et al.
Title
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
Journal
J Immunol 147:2964-9 (1991)
Reference
Authors
Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, et al.
Title
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Journal
Sequence
Reference
Authors
Thornberry NA.
Title
Interleukin-1 beta converting enzyme.
Journal
Reference
Authors
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.
Title
Human ICE/CED-3 protease nomenclature.
Journal
Reference
Authors
Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ.
Title
Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.
Journal
Reference
Authors
Martinon F, Tschopp J
Title
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Journal
Reference
Authors
Chang HY, Yang X.
Title
Proteases for cell suicide: functions and regulation of caspases.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.22.36