Entry
Name
V-cath endopeptidase;
AcNPV protease;
BmNPV protease;
NPV protease;
baculovirus cathepsin;
nucleopolyhedrosis virus protease;
viral cathepsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase of broad specificity, hydrolysing substrates of both cathepsin L and cathepsin B
Comment
In peptidase family C1. Contributes to the liquefaction of the tissues of the insect host in the late stages of infection by the baculovirus.
History
EC 3.4.22.50 created 2003
Orthology
K20741 Baculoviridae V-cath endopeptidase
Reference
Authors
Slack JM, Kuzio J, Faulkner P
Title
Characterization of v-cath, a cathepsin L-like proteinase expressed by the baculovirus Autographa californica multiple nuclear polyhedrosis virus.
Journal
Sequence
Reference
Authors
Hawtin RE, Zarkowska T, Arnold K, Thomas CJ, Gooday GW, King LA, Kuzio JA, Possee RD.
Title
Liquefaction of Autographa californica nucleopolyhedrovirus-infected insects is dependent on the integrity of virus-encoded chitinase and cathepsin genes.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.22.50