KEGG   ENZYME: 3.4.22.53
Entry
EC 3.4.22.53                Enzyme                                 
Name
calpain-2;
calcium-activated neutral protease II;
m-calpain;
milli-calpain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.
History
EC 3.4.22.53 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.53
Orthology
K03853  calpain-2
Genes
HSA824(CAPN2)
PTR457765(CAPN2)
PPS100988890(CAPN2)
GGO101149206(CAPN2)
PON100445754(CAPN2)
NLE100589114(CAPN2)
HMH116457885(CAPN2)
MCC703047(CAPN2)
MCF102122692(CAPN2)
MTHB126937478
MNI105478205(CAPN2)
CSAB103230023(CAPN2)
CATY105576962(CAPN2)
PANU101022030(CAPN2)
TGE112619114(CAPN2)
MLEU105554489(CAPN2)
RRO104677285(CAPN2)
RBB108528248(CAPN2)
TFN117075199(CAPN2)
PTEH111537094(CAPN2)
CANG105502824(CAPN2)
CJC100405215(CAPN2)
SBQ101035587(CAPN2)
CIMI108302703(CAPN2)
CSYR103272581(CAPN2)
MMUR105863767
LCAT123627504(CAPN2)
PCOQ105810138(CAPN2)
OGA100946093(CAPN2)
MMU12334(Capn2)
MCAL110296563(Capn2)
MPAH110321506(Capn2)
RNO29154(Capn2)
MCOC116068107(Capn2)
ANU117721391(Capn2)
MUN110546658(Capn2)
CGE100771239(Capn2)
MAUA101833693(Capn2)
PROB127223719(Capn2)
PLEU114684418(Capn2)
MORG121435859(Capn2)
MFOT126502085
AAMP119799550(Capn2)
NGI103726266(Capn2)
HGL101720177(Capn2)
CPOC100725761(Capn2)
CCAN109677038(Capn2)
DORD105984946(Capn2)
DSP122109365(Capn2)
PLOP125360104(Capn2)
NCAR124961543
MMMA107140516(Capn2)
OCU100009092(CAPN2)
OPI101532667(CAPN2)
TUP102481316(CAPN2)
GVR103607537(CAPN2)
CFA480118(CAPN2)
CLUD112648848(CAPN2)
VVP112923580(CAPN2)
VLG121485762(CAPN2)
NPO129509084(CAPN2)
AML100476150(CAPN2)
UMR103669131(CAPN2)
UAH113262899(CAPN2)
UAR123791973(CAPN2)
ELK111150685
LLV125085781
MPUF101675244(CAPN2)
MNP132025535(CAPN2)
MLK131814739(CAPN2)
NVS122918704(CAPN2)
ORO101364547(CAPN2)
EJU114215532(CAPN2)
ZCA113932475(CAPN2)
MLX118012992(CAPN2)
NSU110571384(CAPN2)
LWW102747421(CAPN2)
FCA101083231(CAPN2)
PYU121015188(CAPN2)
PBG122475955(CAPN2)
LRUF124510321
PPAD109258888(CAPN2)
PUC125925062
AJU106983173
HHV120234148(CAPN2)
BTA281662(CAPN2)
BOM102276298(CAPN2)
BIU109570370(CAPN2)
BBUB102415122(CAPN2)
BBIS104997873
CHX102181227(CAPN2)
OAS100127211(CAPN2)
BTAX128061180(CAPN2)
ODA120880362(CAPN2)
CCAD122452395(CAPN2)
MBEZ129551654(CAPN2)
SSC397393(CAPN2)
CFR102512386(CAPN2)
CBAI105083948(CAPN2)
CDK105099835(CAPN2)
VPC102524736(CAPN2)
BACU103007207(CAPN2) 103019749
LVE103080579(CAPN2)
OOR101270285(CAPN2)
DLE111177507(CAPN2)
PCAD102976041(CAPN2)
PSIU116740338(CAPN2)
NASI112403123(CAPN2)
ECB100055184(CAPN2)
EPZ103563904(CAPN2)
EAI106829535(CAPN2)
MYB102240228(CAPN2)
MYD102769788(CAPN2)
MMYO118678942(CAPN2)
MLF102438585
MNA107543584(CAPN2)
PKL118727621(CAPN2)
EFUS103293526(CAPN2)
HAI109381194(CAPN2)
DRO112318759
SHON119003139
AJM119036522(CAPN2)
PDIC114512462
PHAS123832759(CAPN2)
MMF118640556(CAPN2)
RFQ117018599(CAPN2)
PPAM129072993(CAPN2)
PALE102897695(CAPN2)
PGIG120619310(CAPN2)
PVP105292618(CAPN2)
RAY107498969
MJV108400832(CAPN2)
TOD119244503(CAPN2)
SARA101557601(CAPN2)
LAV100663804(CAPN2)
TMU101341399
ETF101648937(CAPN2)
DNM101424691(CAPN2)
MDO100018672(CAPN2)
GAS123244336(CAPN2)
SHR100922649(CAPN2)
AFZ127559523
PCW110205536(CAPN2)
OAA100081577(CAPN2)
GGA395963(CAPN2)
PCOC116230900(CAPN2)
MGP100546180(CAPN2)
CJO107311033(CAPN2)
TPAI128076189(CAPN2)
LMUT125690047(CAPN2)
NMEL110395702
APLA101799042(CAPN2)
ACYG106031621(CAPN2)
CATA118252991
AFUL116487638
TGU100225408
LSR110483833
SCAN103819275(CAPN2)
PMOA120505963(CAPN2)
OTC121346915(CAPN2)
PRUF121357014(CAPN2)
GFR102045030(CAPN2)
FAB101809391(CAPN2)
OMA130250773(CAPN2)
PHI102111446(CAPN2)
PMAJ107202529(CAPN2)
CCAE111926249(CAPN2)
CCW104685555(CAPN2)
CBRC103612864(CAPN2)
ETL114073709(CAPN2)
ZAB102073190(CAPN2)
ACHL103797775
SVG106853912(CAPN2)
MMEA130583044(CAPN2)
HRT120750694(CAPN2)
FPG101919959(CAPN2)
FCH102048431(CAPN2)
CLV102084552
EGZ104124542(CAPN2)
NNI104019299(CAPN2)
PCRI104030145
PLET104620768
EHS104514071(CAPN2)
PCAO104045095
ACUN113477955(CAPN2)
TALA104365796
PADL103925056(CAPN2)
AFOR103894459(CAPN2)
ACHC115349962(CAPN2)
HALD104317978(CAPN2)
HLE104838213(CAPN2)
AGEN126052620
GCL127015289
CCRI104159172(CAPN2)
CSTI104550979(CAPN2)
CMAC104483676(CAPN2)
MUI104544144
BREG104630494(CAPN2)
FGA104081233(CAPN2)
GSTE104255472(CAPN2)
LDI104350930
MNB103769082(CAPN2)
OHA104332003(CAPN2)
NNT104408713
SHAB115613876
DPUB104300913(CAPN2)
PGUU104471956
ACAR104526948
CPEA104386198(CAPN2)
AVIT104268653
CVF104294692(CAPN2)
RTD128906890(CAPN2)
CUCA104067050(CAPN2)
TEO104376259
BRHI104489251(CAPN2)
AAM106482724(CAPN2)
AROW112963405
NPD112954803(CAPN2)
TGT104570282(CAPN2)
DNE112980095(CAPN2)
SCAM104151845(CAPN2)
ASN102373508(CAPN2)
AMJ102560432(CAPN2)
CPOO109319765(CAPN2)
GGN109296890(CAPN2)
PSS102458713(CAPN2)
CMY102937008(CAPN2)
CCAY125633672
DCC119852740(CAPN2)
CPIC101940996(CAPN2)
TST117874491(CAPN2) 117888892
CABI116825598(CAPN2)
MRV120388744(CAPN12) 120400953(CAPN2)
ACS100561808(capn2)
ASAO132761385(CAPN2)
PVT110075406(CAPN2)
SUND121919237(CAPN2)
PBI103056946
PMUR107288074(CAPN2)
CTIG120307212(CAPN2)
TSR106549641(CAPN2)
PGUT117671750
APRI131189346
PTEX113433240(CAPN2)
NSS113421716(CAPN2)
VKO123024724
PMUA114594632(CAPN2)
PRAF128411079 128418951(CAPN12)
ZVI118083208(CAPN2)
HCG128332565(CAPN12) 128350261
GJA107121636(CAPN2)
STOW125436868
EMC129330026(CAPN2) 129342991 129343726
XLA100127267(XB5844015.L) 108716477(capn8.5.L) 108717697(capn2.S) 399075(capn2.L)
XTR100379861(capn8.5) 100494922 100495980 448035(capn2)
NPR108786661 108787073(CAPN2)
RTEM120913392 120937867
BBUF120977198 120999612(CAPN2)
BGAR122934009(CAPN2)
MUO115465480(CAPN2) 115481010
GSH117356530
DRE337730(capn8) 445091(capn2l) 541374(capn2a) 563053(capn2b)
SRX107722658 107722663 107722669 107724584 107734257 107755343 107755344 107755345 107755925
SANH107655329 107655374 107655376 107655378 107659324 107659328 107676365 107679193
SGH107549147 107565171 107565172 107565180 107566058 107569122 107571859 107577564 107586086
CCAR109046872 109046967 109046972 109047015 109070306 109076939 109081032 109100541 109106274
CAUA113039948 113039949 113039950 113039951 113065066 113065067 113065139 113065999 113092354 113112426
CGIB127942702 127943373 127943374 127956591 127970457 127988414 127988415 127988417 128025938
PTET122327143 122327282(capn2b) 122327288 122327868 122327869 122328220(capn2l) 122356702(capn2a)
LROH127153354(capn2b) 127159477(capn2l) 127159478 127159480 127175321(capn2a)
OMC131530830(capn8) 131531102(capn2l) 131531156 131551993(capn2a)
PPRM120479402(capn2a) 120495254(capn8) 120495255(capn2b) 120495447(capn2l)
RKG130083184(capn2a) 130103527(capn2l) 130103528(capn8)
MAMB125263723(capn2l) 125263724(capn8) 125263725 125263726 125263728 125263731(capn2b) 125276707(capn2a)
CIDE127520139 127520684 127521576 127521577 127524777
MASI127412206 127413959 127438536 127438537 127438758 127438759
TROS130548323(capn2b) 130548655 130548689 130548690(capn2l) 130550965
TDW130429403(capn2b) 130429719 130429728 130430172(capn2l) 130431461(capn2a)
MANU129415666(capn2a) 129452865(capn2b) 129453082 129453423 129453424 129453425 129453426 129453427 129453428 129453429 129453430 129453432 129453433 129453436 129453438
IPU108259404 108259406 108259420
IFU128602567 128602877 128602878
PHYP113547581
SMEO124379814 124380107(capn8)
TFD113656951 113657035 113657038 113657047 113657081 113657082
TVC132838552 132839063(capn8)
AMEX103024279 103026146 107197131
CMAO118804562 118804578 118804588 118804589 118804595 118804599 118804628 118810905(capn2a)
EEE113577726 113581471 113581475
CHAR105896912 105910532 116219353 122129548 122129552 122129555 122132274
TRU101064754 101076184 101076595
TFS130527429 130533559 130533560
TNGGSTEN00008927G001 GSTEN00030802G001 GSTEN00030804G001
LCO104918327 104918337 104934896 104934897 104934898
NCC104963449 104963450
TBEN117499311 117499313 117499673(capn8) 117499674
PGEO117441997 117459873 117459874
GACU117535626 117553009 117553016
ELY117248470 117248471 117255565 117255600 117255876
EFO125885996(capn8) 125885997 125885998 125903649 125903650
PLEP121942132
SLUC116034148 116049140 116049141 116049166 116049190 116051494 116058023 116058030 116058374 116058375 116058502 118496042
ECRA117960009
ESP116704839
PFLV114556645 114556646 114556744 114557816 114557817 114557979 114557980 114563664 114563675 114566584 114572526
GAT120824594 120824596
PPUG119214540 119214541 119217599 119217601 119217602
AFB129092103 129092104 129095536 129095538 129095695
CLUM117729021 117743953 117743954
MSAM119899880(capn2l) 119899881(capn8) 119899882 119917657
SCHU122872848(capn8) 122872850 122884013
CUD121508149 121508172 121510754 121510929
ALAT119019705(capn2l) 119019734(capn8) 119019742(capn2b) 119033589 119034167
MZE101466554 101468385
ONL100706186 100709493 102083160
OAU116317696 116317707(capn8) 116317874(capn2l) 116318507
OLA101162579 101164919 101165172
OML112143530 112162134 112162135
XMA102227133 102234145
XCO114138434 114138435 114144102
XHE116713621 116713624 116720104
PRET103473154 103477212 103477213
PFOR103130124 103134145 103134146
PLAI106959257 106959267 106961194
PMEI106929428 106929429 106931777
GAF122829988 122842935 122842936
PPRL129356041 129359660(capn8) 129359661
CVG107082647 107082675 107102256 107102257
CTUL119785494 119785503 119797741 119797749
GMU124858622 124868214
NFU107375570 107393875
KMR108234077 108234124 108251143 108251144(capn2b)
ALIM106515918(capn11) 106536239
NWH119411348 119411359 119422313
AOCE111568891 111568893 111568895 111585239
MCEP125004579(capn8) 125004580(capn2l) 125004581(capn2b) 125019146 125019147
CSEM103383278 103383281 103387544 103387545
POV109630641 109632323 109647469 109647544
SSEN122762072 122771004 122781965 122781966
HHIP117763891(capn2l) 117763907(capn8) 117763923 117775632 117776037 117776080
HSP118119322 118119434 118119503 118119505 118120876
LCF108877132 108877133(capn8) 108882289
SDU111220638 111220639 111237555 111237556 111237557
SLAL111649592 111658604 111669521 111669522
XGL120796274 120796275 120800453(capn2l) 120800454(capn8) 120800455(capn2b)
HCQ109516162 109527604
SSCV125968492 125978751
SBIA133505698 133509944
PEE133403937 133410220 133410221
PTAO133476952 133485740 133485741
BPEC110156974 110156975 110166012
MALB109960723 109971792 109971799 109971826
BSPL114857498 114857509(capn2b) 114870532 114870586 114870587
SJO128357669 128373143 128373144 128375865 128378195
SASA106565007 106565009 106578800 106578801 106584767 106589959 106589985
STRU115155631 115155640 115201755 115201756 115208449 115208455
OTW112223208 112223950 112236240 112266430(capn8) 112266436
OMY100135837 100136224(capn2) 110491224 110491235 110493820(capn8)
OGO124002438 124003579(capn8) 124039071 124048054 124048056
ONE115107157 115122462 115126231 115142697 115142699
OKI109879240 109880977 109890699 109890707 116355398
OKE118376416 118379311 118379869 118389064 118389067(capn8)
SALP111960924 111960936
SNH120022367(capn8) 120029335 120045314 120045401 120064858
CCLU121555339 121572329 121572330(capn8) 121580572 121580650 123484545
ELS105028009 105028010 105031125
SFM108927097 108927098 108927128 108933713 108933714
PKI111835677 111841738 111852308 111852340 111852381 111852382
AANG118212877 118212878 118217793(capn2a) 118218445 118218446(capn8) 118220682 118220959
LOC102683469 102686084 102686287
PSPA121315710 121315712 121316792 121316797 121316798
ARUT117402852 117403231 117403377 117410845 117410846 117411201
PSEX120516279(capn8) 120516295(capn2l) 120516636 120516907
LCM102347065(CAPN2)
CMK103177931
RTP109927474
HOC132819701 132830514
LERI129699624
PMRN116943157
AGIF122847603 122849323
FOC113203230
TPAL117639677
PVUL126817811
GAE121379756 121386152 121386313
HRF124115873 124136697 124145344
HRJ124274220 124291720
CVN111110708 111127234
OED125666590
MMER123566327
RPHI132718623 132745282
DPOL127877971
OSN115209388
 » show all
Reference
1  [PMID:10639123]
  Authors
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.
  Title
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
  Journal
Proc Natl Acad Sci U S A 97:588-92 (2000)
DOI:10.1073/pnas.97.2.588
  Sequence
[hsa:824]
Reference
2  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.53
IUBMB Enzyme Nomenclature: 3.4.22.53
ExPASy - ENZYME nomenclature database: 3.4.22.53
BRENDA, the Enzyme Database: 3.4.22.53
CAS: 702693-80-9

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