HIV-1 retropepsin;
human immunodeficiency virus type 1 protease;
gag protease;
HIV aspartyl protease;
HIV proteinase;
retroproteinase;
HIV-1 protease;
HIV-2 protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
Comment
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2