KEGG ENZYME: 3.4.23.3

ENZYME: 3.4.23.3

Entry

EC 3.4.23.3                 Enzyme

Name

gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin

Comment

Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).

History

EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986

Orthology

K01377

gastricsin

Genes

HSA:

5225(PGC)

PTR:	107975138(PGC) 469410

PPS:	100974556(PGC)

GGO:	101129549(PGC)

PON:	100271706(PGC)

NLE:	100583614(PGC)

HMH:	116460032(PGC)

MCC:	695713(PGC)

MCF:	102124827(PGC)

MTHB:

126953797

MNI:	105489618(PGC)

CSAB:

103221511(PGC)

CATY:

105591935(PGC)

PANU:

100137209(PGC)

TGE:	112623421(PGC)

MLEU:

105544289(PGC) 105554396

RRO:	104667302(PGC)

RBB:	108533509(PGC)

TFN:	117087201(PGC)

PTEH:

111543032(PGC)

CANG:

105513060(PGC)

CJC:	100404738(PGC)

SBQ:	101046472(PGC)

CIMI:

108283170 108317076(PGC)

CSYR:

103264883(PGC) 103271458

MMUR:

105864060 105875872(PGC)

LCAT:

123631860(PGC) 123634591

PCOQ:

105807424(PGC) 105822082

OGA:	100954923(PGC) 100961595

MMU:	109820(Pgc)

MCAL:

110284112(Pgc)

MPAH:

110335889(Pgc)

RNO:	24864(Pgc)

MCOC:

116074734(Pgc)

ANU:	117722594(Pgc)

MUN:	110550245(Pgc)

CGE:	100770180(Pgc)

MAUA:

101831401(Pgc)

PROB:

127236790(Pgc)

PLEU:

114705363(Pgc)

MORG:

121451030(Pgc)

MFOT:

126488949

AAMP:

119823537(Pgc)

NGI:	103725818(Pgc)

HGL:	101713573(Pgc)

CPOC:

100135598(Pgc)

CCAN:

109682091(Pgc) 109690302

DORD:

105987777(Pgc)

DSP:	122101501(Pgc)

PLOP:

125352599(Pgc)

NCAR:

124988730 124988731 124988979

MMMA:

107143633 107143634 107144073(Pgc)

OCU:	100009323(PGC)

OPI:	101533754(PGC)

TUP:	102468155(PGC) 102471668

GVR:	103583291 103587470(PGC)

CFA:	403552(PGB1) 609052(PGC)

CLUD:

112640662 112640663(PGB1) 112641854(PGC) 125755195

VVP:	112907206 112907886 112914212(PGC)

VLG:	121472163(PGC) 121486385 121487121

NPO:	129513060(PGC) 129520240 129520266

AML:	100465306(PGC) 100474233(PGB2)

UMR:	103664167(PGC) 103675035(PGB1) 103675037

UAH:	113261042(PGC)

UAR:	123779176(PGC) 123794940 123794941

ELK:	111142948 111142951 111147505

LLV:	125098440 125098442 125101959

MPUF:

101689476 101693498(PGC) 101693781

MNP:	132000639 132000643 132017293(PGC)

MLK:	131809975 131809976 131833188(PGC)

NVS:	122898797 122898799 122899503(PGC)

ORO:	101370826(PGC) 101377876

EJU:	114204670(PGC) 114208059

ZCA:	113927222(PGC)

MLX:	118000901(PGC) 118018937

NSU:	110580468(PGB1) 110582128(PGC)

LWW:	102741065 102742953 102743266

FCA:	101100053(PGC) 111556254(PGB1)

PYU:	121026647 121026649 121029436(PGC)

PCOO:

112862812(PGC)

PBG:	122479442 122479635 122489504(PGC)

PVIV:

125166171(PGC) 125173923

LRUF:

124514459 124516552 124529325

PTG:	102948554(PGC) 102964203 102965559

PPAD:

109271603(PGC) 109272037 109272192

PUC:	125917651 125938252

AJU:	106969657 106974058 128313953

HHV:	120223472 120223490 120238740(PGC)

BTA:	514502(PGC)

BOM:	102288190(PGC)

BIU:	109577457(PGC)

BBUB:

102407704(PGC)

BBIS:

105005252(PGC)

CHX:	102189914(PGC)

OAS:	101106633(PGC)

BTAX:

128056639(PGC)

ODA:	120870136(PGC)

CCAD:

122429554(PGC)

MBEZ:

129543579(PGC)

SSC:	100521201(PGC) 100620249

CFR:	102523783(PGC)

CBAI:

105083768(PGC)

CDK:	105086751(PGC)

VPC:	102528234(PGC)

BACU:

103010186(PGC)

BMUS:

118903802(PGC)

LVE:	103070634(PGC)

OOR:	101276675(PGC)

DLE:	111178617(PGC)

PCAD:

102984618(PGC)

PSIU:

116761991(PGC)

NASI:

112413972(PGC)

ECB:	100066460(PGC)

EPZ:	103563497(PGC)

EAI:	106824587(PGC)

MYB:	102255177(PGC) 102261843

MYD:	102755151(PGC) 102772869

MMYO:

118660362(PGC) 118673372

MLF:

102420032

PKL:	118705507(PGC) 118727498

EFUS:

103291178(PGB) 103301925(PGC)

MNA:	107536852(PGC) 107545243

DRO:	112302163(PGC)

SHON:

118993918(PGC)

AJM:	119055617(PGC)

PDIC:

114489240(PGB) 114495354(PGC)

PHAS:

123804647 123821575(PGC)

MMF:	118621577(PGC) 118637873

PPAM:

129063669 129067034(PGC)

HAI:	109373549 109382920(PGC)

RFQ:	117014974 117020439(PGC)

PALE:

102877967(PGC) 102881919

PGIG:

120584944 120596277(PGC)

PVP:	105288561(PGC)

RAY:	107501928(PGC)

MJV:	108389215 108395077(PGC)

TOD:	119235236 119252449(PGC)

SARA:

101540464(PGC) 101553208

LAV:	100665648(PGC) 100675371

TMU:	101349705 101353827

ETF:	101638499(PGC) 101653423

DNM:	101412500(PGC) 101429457

MDO:	100027327 100027345 100027368 100027389 554184(PGC)

GAS:	123245311(PGC) 123247164 123256217

SHR:	100917515 100919336 116423409

AFZ:	127559334 127561731 127561732

PCW:	110204032 110204033 110216792

GGA:	395690(PGC) 428272(GASTL)

PCOC:

116236958 116237053

MGP:	100546064 100546220

CJO:	107324900 107324901

TPAI:

128087963 128088146

LMUT:

125684124 125684131(PGC)

NMEL:

110388247 110388248

APLA:

101792780 101794692(PGC)

ACYG:

106045837 106045861

CATA:

118255277 118255439(PGC)

AFUL:

116498674 116498817

TGU:	105758893(PGC)

LSR:	110477157(PGC)

SCAN:

103823313(PGC)

PMOA:

120495962(PGC)

OTC:	121348014(PGC)

PRUF:

121354004(PGC)

GFR:	102041764(PGC)

FAB:	101807666(PGC)

OMA:	130263706(PGC)

PHI:	102107379 102107560

PMAJ:

107214993 107214994

CCW:	104692528 120411261(PGC)

CBRC:

103625310 103625369

ETL:	114070527 114070528

ACHL:

103808854 103811646(PGC)

SVG:	106851087(PGC)

MMEA:

130586659(PGC)

HRT:	120762793 120762794

FPG:	101912673 101912850

FCH:	102048513 106630797

CLV:	102091578(PGC)

EGZ:	104125729 104125730

NNI:	104013154 104013155(PGC)

PCRI:

104029729 104029805(PGC)

PLET:

104619296 104619297

EHS:	104509363(PGC) 104509365

PCAO:

104042869 104042877

ACUN:

113488821 113488823

TALA:

104364659 104364660

PADL:

103919814(PGC) 103919816

AFOR:

103893624 103893708

ACHC:

115335172 115335173

HALD:

104317391(PGC) 104323486

HLE:	104842395 104842396

AGEN:

126052061 126052062

GCL:	127026322 127026323

CCRI:

104158199(PGC) 104161049

CSTI:

104555981(PGC)

CMAC:

104477990 104485872

MUI:	104546130(PGC) 104546131

BREG:

104642632(PGC) 104642633

FGA:	104081102 104081103

GSTE:

104263264 104263265

LDI:	104343889 104353864(PGC)

MNB:

103779971

NNT:	104408214 104408215

SHAB:

115602323 115602335

DPUB:

104305349 104305392(PGC)

PGUU:

104465675 104465676

ACAR:

104524375 104524376

CPEA:

104397136(PGC) 104397137

AVIT:

104278644 104278645

CVF:	104289315(PGC) 104289316

RTD:	128900443 128900444

CUCA:

104067080(PGC) 104067081

TEO:	104374707 104374708

BRHI:

104498625 104498628

AAM:	106494351 106494352 106494353(PGC)

AROW:

112961416 112961418 112961419

NPD:	112959192(PGC) 112959193 112959194

TGT:	104573317 104573319

DNE:	112990287 112990305

SCAM:

104146457 104146458 104146467

ASN:	102368438 102368697 102368950 102380415

AMJ:	102562220 102562457 102564094 106736665(PGC)

CPOO:

109317680 109317781(PGC)

GGN:	109295112 109295383 109295384 109295385(PGC)

PSS:	102443428 102443684 102463493 102463918

CMY:	102941343 102941576 119564418

CCAY:

125625050

DCC:	119846239 119846530

CPIC:

101944245 101944509 101944783 101945053

TST:	117875842 117875843 117875844 117875845

CABI:

116817833 116818103 116818123 116818131

MRV:	120404383 120404384 120404490 120404577

ACS:	100566938 100567135 100567523

ASAO:

132773676 132773677 132773678 132773679

PVT:	110081367 110081374(PGC)

SUND:

121928825 121929503 121929504 121929505

PBI:	103055509 103056934 103066093

PMUR:

107291548 107299949 107299950 107300480

CTIG:

120306532 120306537 120306542

TSR:	106540681(PGC)

PGUT:

117658762

APRI:

131195057

PTEX:

113446110(PGC)

NSS:	113428458(PGC) 113430517

VKO:	123034113 123034120 123034127 123034134 123034138 123034147

PMUA:

114598354 114598355 114598356 114598357

PRAF:

128416053 128416054 128416055 128416057

ZVI:	118088671 118089240 118089241 118089242

HCG:	128323670 128323671 128323672 128323673

GJA:	107107325 107107326 107107327 107107328

STOW:

125432542 125432543(PGC) 125433372

EMC:	129330151 129330152 129330749 129330831

XLA:	108704545 108704546 108709103 108709104(pgc.S) 373563(XB964428.S)

XTR:	100489782 496913 548353(pgc) 594991(pgc) 613072

NPR:	108804878 108804879 108804887 108804890 108804897 108804900

RTEM:

120927176 120927177 120927179 120927180 120927181 120927182

BBUF:

120993348 120993349 120993350 120993351 120993352 120993353 120993728 120993729

BGAR:

122922647 122922648 122922649 122932317 122932459 122932529

MUO:	115482011 115482012 115482013 115482014

GSH:	117347522(PGC) 117347675

IPU:	108264667 108264670 108266400 108266401 124628081

IFU:	128606954 128606955 128609060 128609062

PHYP:

113524721 113526108 113534331

SMEO:

124395392 124395393

TFD:	113645383 113652781

TVC:	132850360 132850361 132851392

AMEX:

103027414(pgc) 103031313 103038890

CMAO:

118807588 118817956

EEE:	113577941 113577942 113577957 113580521(pgc)

CHAR:

105907900 116219991 116219992

LCO:

104940478

TBEN:

117478741

CGOB:

115009416

PGEO:

117456402 117456453

GACU:

117542921

EMAC:

134881177

ELY:

117262167

EFO:

125886728

PLEP:

121949848

SLUC:

116045622

ECRA:

117949579

ESP:

116694704

PFLV:

114559916

GAT:

120808852

PPUG:

119195564

AFB:

129108132

CLUM:

117732419

PSWI:

130195136

MSAM:

119893771

SCHU:

122874689

ALAT:

119024692

AOCE:

111583223 111583917

MCEP:

125014538

POV:	109624424(pgc)

HHIP:

117763167

HSP:

118109700

SMAU:

118315096

LCF:

108875170

SDU:	111228596(pgc)

SLAL:

111671242

XGL:

120792717

MALB:

109967483

BSPL:

114857009

SJO:

128358429

SASA:

106561235 106561236

STRU:

115197262 115197264 115197265

OTW:	112218646 121838767 121840072 121840073

OMY:	110496598 110496606 110496614

OGO:	124019375 124035892

ONE:	115134187 115134188 115134189

OKI:	109867233 109867235 116356277

OKE:	118395713 118395714

SALP:

112068576 112077499 112078742

SNH:	120025049 120025060 120025071

CCLU:

121531982 121531983

ELS:	105022187 105022190

SFM:	108924268 108936564 108936565 108936566 108936567

PKI:	111842453(pgc) 111858572 111859331

AANG:

118219157

LOC:	102686226 102693407(pgc)

PSPA:

121299561 121299841 121299845 121299847 121300146 121322055 121323511

ARUT:

117396739 117396750 117396758 117407111 117426727 117426791 117432862 117964470

PSEX:

120531206 120536167 120536168 120536438

LCM:	102354616(PGC)

RTP:

109913610

CPLA:

122563100 122563102

HOC:	132828352 132828356

LERI:

129708908

MQU:

128989067

RSAN:

119373383

BMY:	BM_BM3492(Bma-hrg-7)

LOA:	LOAG_08037

OVI:	T265_12844

CAUR:

CJI96_0002104

FVN:	FVRRES_13775

CCAC:

CcaHIS019_0300080(CcaverHIS019_0300080)

RSX:	RhiXN_07392 RhiXN_10332 RhiXN_11717

E1B28_002550 E1B28_013168

» show all

Reference

Authors

Ryle, A.P.

Title

The porcine pepsins and pepsinogens.

Journal

Methods Enzymol 19:316-336 (1970)

Reference

Authors

Tang, J.

Title

Gastricsin and pepsin.

Journal

Methods Enzymol 19:406-421 (1970)

Reference

3 [PMID:6795036]

Authors

Foltmann B.

Title

Gastric proteinases--structure, function, evolution and mechanism of action.

Journal

Essays Biochem 17:52-84 (1981)

Reference

4 [PMID:6816595]

Authors

Foltmann B, Jensen AL.

Title

Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.

Journal

Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x

Sequence

[hsa:5225]

Reference

5 [PMID:6800788]

Authors

Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.

Title

Purification and characterization of bovine gastricsin.

Journal

Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x

Reference

6 [PMID:6432332]

Authors

Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.

Title

Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

Journal

Cell Tissue Res 236:597-600 (1984)
DOI:10.1007/bf00217228

Reference

7 [PMID:3335549]

Authors

Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.

Title

Primary structure of human pepsinogen C gene.

Journal

J Biol Chem 263:1382-5 (1988)

Sequence

[hsa:5225]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.23.3

IUBMB Enzyme Nomenclature:

3.4.23.3

ExPASy - ENZYME nomenclature database:

3.4.23.3

BRENDA, the Enzyme Database:

3.4.23.3

CAS:

9012-71-9

DBGET integrated database retrieval system