Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala14!Leu, Tyr16!Leu, and Phe24!Phe
Comment
From the basidiomycete Pycnoporus sanguineus, formerly known as P. coccineus and Trametes sanguinea. Formerly included in EC 3.4.23.6
History
EC 3.4.23.30 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Reference
1
Authors
Tomoda, K. and Shimazono, H.
Title
Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme.
Journal
Agric Biol Chem 28:770-773 (1964)
Reference
2
Authors
Tsuru, D., Hattori, A., Tsuji, H., Yamamoto, T. and Fukumoto, J.
Title
Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis.
Journal
Agric Biol Chem 33:1419-1426 (1969)
Reference
3
Authors
Ichishima, E., Kumagai, H. and Tomoda, K.
Title
Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus.
