chymosin;
rennin (but this should be avoided since it leads to confusion with renin)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105!Met-Ala bond in kappa-chain of casein
Comment
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)
History
EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986
Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.