KEGG ENZYME: 3.4.23.40

ENZYME: 3.4.23.40

Entry

EC 3.4.23.40                Enzyme

Name

phytepsin

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe!Asp- and -Asp!Asp- bonds in 2S albumin from plant seeds

Comment

Known particularly from barley grain, but present in other plants also. In peptidase family A1 (pepsin A family), but structurally distinct in containing an internal region of about 100 amino acids not generally present in the family

History

EC 3.4.23.40 created 1997

Orthology

K08245

phytepsin

Genes

AEC:

105146985

CFO:	105255115 105255863 112639472

LDC:

111511468

ATH:	AT1G11910(APA1) AT1G62290 AT4G04460

ALY:	9308762 9322547 9325967 9330736

CRB:	17881324 17895239 17896448 17898275 17900186

CSAT:

104701092 104701093 104703829 104714562 104716987 104737288 104739839 104752884 104755449 104759012 104759013 104770715 104773448 104787437 104787438

EUS:	EUTSA_v10007418mg EUTSA_v10023414mg EUTSA_v10028587mg

BRP:	103836199 103838666 103839838 103843214 103848160 103858657

BNA:	106362176 106366922 106368609 106376996 106396368 106415098 106415178 106434262 106435833 106438757 106442725 106442742 111204471

BOE:	106311623 106311961 106312989 106319225 106329520 106337618

RSZ:	108820622 108822743 108823281 108824165 108834183 108843647 108844870 108846785 130504716 130509242

THJ:	104806312 104813344 104818674 104820456 104823533

CPAP:

110808041 110811561 110815336 110818242 110818868

CIT:	102608561 102620813 102622108 102625358 102628488

CIC:	CICLE_v10004801mg CICLE_v10008027mg CICLE_v10011525mg CICLE_v10014941mg CICLE_v10017754mg

PVY:	116106316 116133382 116143206 116143260 116144485

MINC:

123196311 123200696 123205002 123207507 123219614 123220234 123220533

TCC:	18593467(ap1) 18597190(ap2) 18600638 18603785 18603786 18612296

GRA:	105773350 105776997 105780938 105790234 105792454 105796982 105796983

GHI:	107893740 107910509 107917808 107920178 107922162 107925242 107926283 107933813 107935407 107951558 107951559 107962007 121230711

GAB:	108464467 108469854 108474886 108475469 108483309 108486737 108489462

HSYR:

120119707 120147159 120155852 120160460 120163634 120170705 120172482 120174805 120189322 120189950 120191325 120198421 120202430 120204216 120206097 120218505

DZI:	111275213 111275658 111278282 111283372 111301588 111305631 111307547 111307548

EGR:	104415305 104424752 104426616 104431494 104435229 104441421 104448211

GMX:	100500551 100776327 100779619 100782139 100785602 100793160 100796053 100801598 547478(SOYAP1) 547943 547993 548009(SOYAP2)

GSJ:	114368043 114371145 114381405 114386494 114386526 114393674 114393916 114400074 114403291 114407514 114420190 114425603

PVU:	PHAVU_001G222100g PHAVU_003G0808001 PHAVU_003G125000g PHAVU_006G147900g PHAVU_007G205100g PHAVU_009G220600g

VRA:	106757806 106760823 106767738 106768520 106772254 106776241 106778333

VAR:	108318710 108319443 108329584 108333032 108340923 108347131

VUN:	114177435 114178140 114183978 114186131 114189151 114191563 114196007

VUM:	124824957 124831243 124833639 124838514 124838554 124838564 124845594

CCAJ:

109788087 109788311 109797728 109804488 109807921 109808275 109817402

APRC:

113845838 113846362 113863847 113868593 113873403 113873521

MTR:	11422330 11427124 11432055 25485793 25486204 25494147

TPRA:

123882860 123885812 123891007 123896371 123899104 123907177 123907321

CAM:	101494623 101499205 101499470 101500643 101503657 101507435(AP2)

PSAT:

127077664 127091463 127125886 127132495 127138347 127138752 127138782

VVO:	131594684 131599843 131599890 131602058 131610504 131636775 131642081 131644014

LJA:

Lj0g3v0077119.1(Lj0g3v0077119.1) Lj0g3v0080919.1(Lj0g3v0080919.1) Lj0g3v0080919.2(Lj0g3v0080919.2) Lj0g3v0254609.1(Lj0g3v0254609.1) Lj0g3v0282749.3(Lj0g3v0282749.3) Lj1g3v4807400.1(Lj1g3v4807400.1) Lj3g3v1312770.1(Lj3g3v1312770.1) Lj4g3v0135640.1(Lj4g3v0135640.1) Lj4g3v0135640.2(Lj4g3v0135640.2) Lj4g3v0135640.3(Lj4g3v0135640.3)

ADU:	107465116 107466524 107470354 107478939 107482981 107492241

AIP:	107617753 107630571 107635625 107636348 107638639 107645987

AHF:	112695623 112705938 112707187 112710678 112722713 112722879 112741236 112757981 112775230 112777011 112790633 112795934

LANG:

109327115 109329853 109334777 109336349 109337407 109341462 109343296 109345851 109354330

PCIN:

129285880 129292647 129298784 129298785 129303696 129311273 129311283 129313061 129319812 129321173

QSA:	O6P43_003754 O6P43_007375 O6P43_010978 O6P43_011943 O6P43_021194 O6P43_028661 O6P43_031266

FVE:	101291158 101296033 101300124 101304861 101312909

RCN:	112165512 112165703 112188085 112192552 112197383

PPER:

18772585 18780194 18780680 18783631 18788287

PMUM:

103323394 103324422 103326423 103329303 103344509

PAVI:

110752815 110763092 110763913 110764268 110770575

PDUL:

117616074 117621279 117624068 117624565 117629615

MDM:	103404836 103412547 103421679 103430083 103433833 103434487 103441522 103443260 103452605

MSYL:

126583359 126587481 126589305 126596386 126607556 126612292 126615867 126619112 126621599

PXB:	103938812 103944551 103944705 103948200 103949341 103951388 103955847

ZJU:	107411703 107414182 107419565 107432728 107433313

MNT:	21391452 21397331 21405462 21408796

CSAV:

115694810 115699630 115707726 115719321 115723413

CSV:	101216329 101221973 101222990

CMO:	103484625 103485179 103491074

BHJ:	120072640 120083183 120091893

MCHA:

111010734 111012426 111019253

CMAX:

111477945 111490008 111495439 111500293

CMOS:

111431547 111438595 111453266 111456960

CPEP:

111783063 111802486 111803902 111810790

RCU:	8261920 8266253 8274963 8277993 8285897

JCU:	105632987 105643646 105646364 105647372 105649310

HBR:	110633350 110641937 110653716 110655995 110659453 110664583 110664584 110669099 110670645 110673427

MESC:

110601409 110604154 110611986 110612143 110623105 110626623 110629795

POP:	18097350 18111207 7458299 7477206 7478710 7478872 7479135

PEU:	105107190 105108382 105112452 105113518 105125212 105135716 105141253 105141437

PALZ:

118034940 118042686 118050908 118056834 118057346 118060872 118061371

JRE:	108982507 108984384 108984647 108985443 108987896 109005662 109011629 109012563 109021769

CILL:

122276551 122279752 122281420 122300301 122303794 122307517 122316663 122316814 122317825 122317979

CAVE:

132168937 132173090 132173739 132174863 132174875 132180597

QSU:	111987721 111996592 111996649 112000226 112003722 112013027 112033138 112036536 112039712

QLO:	115950858 115950859 115954898 115955495 115955497 115955498 115979130 115991861

TWL:	119985329 119990021 119991727 119999945 120005410 120007996 120013729

VVI:	100233021 100251117 100261280 100266485 100267436

VRI:	117909542 117914024 117923617 117929637 117929638 117933153

SLY:	101248260 101257143 101258304 101258506 101258673 543969

SPEN:

107002743 107009084 107011492 107012412 107025955 107031509

SOT:	102577765 102582495 102587740 102595736 102604732 102606096

SSTN:

125847609 125848115 125851833 125858617 125868259 125875752

SDUL:

129873278 129873927 129883050 129886019 129891805 129896661

CANN:

107839752 107853537 107857549 107859606 107864683 107868479

LBB:	132598517 132606317 132610703 132610756 132616579 132618648 132621777

NTA:	107763186 107766898 107774817 107787118 107787679 107800406 107808002 107809122 107818093 107818598 107828978 107830673 107832672 107832722

NSY:	104216042 104220638 104221891 104227784 104239553 104244166 104247607

NTO:	104084805 104096002 104102620 104108700 104111394 104119605 104121505

NAU:	109214842 109214959 109219784 109228870 109230803 109232191 109236423

INI:	109165652 109165703 109167232 109175274 109182037 109187318

ITR:	116001531 116007011 116007443 116030261 116031712 116032088

SIND:

105167997 105169005 105175325 105178490

OEU:	111382190 111386994 111389388 111410787

EGT:	105961746 105962226 105968764 105978161

SSPL:

121746210 121755465 121755559 121758727 121759605 121775448 121783545 121787692 121811135

SMIL:

130985816 131009393 131011219 131022083

SHIS:

125189006 125195549 125201082 125210599 125222562

APAN:

127247854 127249761 127254477 127262130 127266012

HAN:	110903666 110915583 110917750 110924656 110929455 110930673 110934485 110936437 110938157

ECAD:

122582182 122592365 122594414 122595517 122595518 122595771 122599176

LSV:	111896329 111905658 111907863 111907864 111907867 111915340 111919101

CCAV:

112500141 112500489 112500491 112500591 112500683 112501419 112503569 112507681 112522622

DCR:	108197384 108204766 108204854 108204900 108206190 108210118 108223471

CSIN:

114265088 114265089 114267284 114270214 114275228 114286351 114307551 114319383

RVL:	131308736 131308737 131315262 131322414 131327427 131330667

AEW:	130752863 130758809 130760831 130764500 130780131 130783495 130784452 130786896 130789963 130794172

BVG:	104884538 104890627 104890648 104900968 104906932

SOE:	110792417 110792677 110794932 110797237 110797239

CQI:	110687394 110701243 110701245 110710924 110717692 110731311 110734052 110736571 110736574 110738610

ATRI:

130804692 130805301 130815366 130817816 130817819 130824049 130828432

MOF:	131149711 131151119 131153992 131154419

NNU:	104586038 104586039 104588302 104594044 104607174 104607178

MING:

122059549 122063721 122093817 122093845

TSS:	122639723 122642406 122658950

PSOM:

113287988 113303177 113316990 113333120 113347049 113348560

OSA:	4325154 4326588 4327861 4337744 4339639

DOSA:

Os01t0290000-01(Os01g0290000) Os01t0631900-00(Os01g0631900) Os01t0663400-01(Os01g0663400) Os05t0137400-01(Os05g0137400) Os05t0567100-01(Os05g0567100)

OBR:	102701267 102710204 102717940 102720467

OGL:	127763015 127768995 127771803 127773282 127773648

BDI:	100821194 100839392 100839510 100842338 100844468

ATS:	109739751 109742347 109748912 109749282 109761984 109771027

TDC:	119268455 119268570 119276344 119292423 119318402 119323847 119327515 119336793 119349609 119364203

TAES:

123061554 123061659 123070187 123078630 123078729 123110880 123128863 123139369 123146008 123146520 123148185 123159760 123165155 123180355 123183165 778397 778398

TUA:	125515248 125518552 125544207 125544298 125547693

LPER:

127307404 127310350 127327658 127338517 127341239 127343052 127343212 127343213 127346803

LRD:	124660243 124660359 124661528 124661789 124661838 124663401 124663406 124663503 124687077 124690017 124690019 124690020 124690303 124702326 124706495 124707095 124708666

SBI:	110430129 110430277 110433911 110434033 8058198

ZMA:	100280169 100282399 100284362 100286141 100383486 103628171 103630292 103631003 103633299 103639786 103643478

SITA:

101763215 101766112 101767950 101772307 101785260

SVS:	117847211 117849529 117854640 117857223 117857921

PVIR:

120664193 120664616 120672236 120673319 120676323 120697382 120697820 120706617 120707529 120710080

PHAI:

112885686 112885930 112893042 112893685 112894517

PDA:	103703338 103712706 103714729 103714982

EGU:	105035462 105041016 105047184 105048551 105048553

MUS:	103977059 103979758 103980369 103992824 103996147 103997141 103999762 104001038

ZOF:	121970586 121975655 121976880 122002236 122006495 122007287 122007932 122015428 122018524 122018743 122022477 122022502 122035974 122037470 122048787

DCT:	110093802 110098713 110104646 110114425

PEQ:	110022421 110022751 110027512 110033544

AOF:	109826586 109829263 109843577 109845279 109848523

MSIN:

131230831 131240749 131245670

NCOL:

116257741

ATR:	18428769 18430140

SMO:	SELMODRAFT_142401 SELMODRAFT_147484 SELMODRAFT_166719 SELMODRAFT_186535 SELMODRAFT_230037 SELMODRAFT_438819

PPP:	112282012 112283085 112292013

VCN:	VOLCADRAFT_81669

MNG:

MNEG_6205

CSL:	COCSUDRAFT_48914

CVR:	CHLNCDRAFT_59800

APRO:

F751_0309

OLU:	OSTLU_44385

OTA:	OT_ostta11g03030

BPG:	Bathy13g00240

MIS:	MICPUN_106372

MPP:	MICPUCDRAFT_51434(JGI:MicpuC2_51434)

ACAN:

ACA1_173660

SMIN:

v1.2.028921.t1(symbB.v1.2.028921.t1)

» show all

Reference

1 [PMID:1722454]

Authors

Runeberg-Roos P, Tormakangas K, Ostman A

Title

Primary structure of a barley-grain aspartic proteinase. A plant aspartic proteinase resembling mammalian cathepsin D.

Journal

Eur J Biochem 202:1021-7 (1991)
DOI:10.1111/j.1432-1033.1991.tb16465.x

Sequence

[ag:CAA39602]

Reference

2 [PMID:7763475]

Authors

Kervinen J, Sarkkinen P, Kalkkinen N, Mikola L, Saarma M.

Title

Hydrolytic specificity of the barley grain aspartic proteinase.

Journal

Phytochemistry 32:799-803 (1993)
DOI:10.1016/0031-9422(93)85208-9

Reference

3 [PMID:7556174]

Authors

Asakura T, Watanabe H, Abe K, Arai S

Title

Rice aspartic proteinase, oryzasin, expressed during seed ripening and germination, has a gene organization distinct from those of animal and microbial aspartic proteinases.

Journal

Eur J Biochem 232:77-83 (1995)
DOI:10.1111/j.1432-1033.1995.tb20783.x

Sequence

[osa:4339639]

Reference

4 [PMID:8540324]

Authors

Kervinen J, Tormakangas K, Runeberg-Roos P, Guruprasad K, Blundell T, Teeri TH.

Title

Structure and possible function of aspartic proteinases in barley and other plants.

Journal

Adv Exp Med Biol 362:241-54 (1995)
DOI:10.1007/978-1-4615-1871-6_28