KEGG   ENZYME: 3.4.23.42
Entry
EC 3.4.23.42                Enzyme                                 
Name
thermopsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1'
Comment
From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 _degree_C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5.
History
EC 3.4.23.42 created 1992 as EC 3.4.99.43, transferred 2000 to EC 3.4.23.42
Orthology
K01385  thermopsin
Genes
TAC: Ta0167
TVO: TVG0251055(TVG0251055)
PTO: PTO0161 PTO1487
SSO: SSO1886 SSO2045
SOL: Ssol_2683
SSOA: SULA_2704
SSOL: SULB_2705
SSOF: SULC_2702
SSHI: J5U23_02199
SCAS: SACC_26470 SACC_29330
SAI: Saci_1049 Saci_1534 Saci_1714(thpS) Saci_2170
SACN: SacN8_08325
SACR: SacRon12I_08340
SACS: SUSAZ_08125
SIS: LS215_0927
SIA: M1425_0700
SIM: M1627_0704
SID: M164_0728
SIY: YG5714_1001
SIN: YN1551_1874
SII: LD85_0747
SIH: SiH_0641
SIR: SiRe_0691
SIC: SiL_0729
SULL: EWF20_04710 EWF20_05945 EWF20_06325 EWF20_06515
MEMJ: MJ1HA_1115 MJ1HA_1673
MTEN: GWK48_10805
MJN: MjAS7_1889 MjAS7_2553
AHO: Ahos_0202 Ahos_1786
ACIH: HS5_07690 HS5_14780
CSTY: KN1_13100 KN1_28110
SMET: RQ359_001099 RQ359_001182 RQ359_001463
SAHS: HS7_12910
CMA: Cmaq_1218
TTN: TTX_0358(thpS)
TUZ: TUZN_1549
TPE: Tpen_1285
FFO: FFONT_0178
CCAI: NAS2_0367
 » show all
Reference
1  [PMID:7674919]
  Authors
Lin X, Tang J.
  Title
Thermopsin.
  Journal
Methods Enzymol 248:156-68 (1995)
DOI:10.1016/0076-6879(95)48013-7
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.42
IUBMB Enzyme Nomenclature: 3.4.23.42
ExPASy - ENZYME nomenclature database: 3.4.23.42
BRENDA, the Enzyme Database: 3.4.23.42
CAS: 126125-05-1

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Gene (56)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (55)   
Protein sequence (47)   
   UniProt (45)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (91)   
   RefSeq(nuc) (56)   
   GenBank (17)   
   EMBL (18)   
Protein domain (1)   
   InterPro (1)   
All databases (195)   

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